Publication Date:
2002-03-09
Description:
The classical recessive mouse mutant, Purkinje cell degeneration (pcd), exhibits adult-onset degeneration of cerebellar Purkinje neurons, retinal photoreceptors, olfactory bulb mitral neurons, and selected thalamic neurons, and has defective spermatogenesis. Here we identify Nna1 as the gene mutated in the original pcd and two additional pcd alleles (pcd2J and pcd3J). Nna1 encodes a putative nuclear protein containing a zinc carboxypeptidase domain initially identified by its induction in spinal motor neurons during axonal regeneration. The present study suggests an unexpected molecular link between neuronal degeneration and regeneration, and its results have potential implications for neurodegenerative diseases and male infertility.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fernandez-Gonzalez, Angeles -- La Spada, Albert R -- Treadaway, Jason -- Higdon, Jason C -- Harris, Belinda S -- Sidman, Richard L -- Morgan, James I -- Zuo, Jian -- CA 23944/CA/NCI NIH HHS/ -- CA21765/CA/NCI NIH HHS/ -- DC 04761/DC/NIDCD NIH HHS/ -- ES 10772/ES/NIEHS NIH HHS/ -- EY 12950/EY/NEI NIH HHS/ -- NS 40361/NS/NINDS NIH HHS/ -- RR 01183/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 2002 Mar 8;295(5561):1904-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11884758" target="_blank"〉PubMed〈/a〉
Keywords:
Alleles
;
Animals
;
*Axotomy
;
Blotting, Northern
;
Brain/metabolism
;
*Carboxypeptidases
;
Chromosome Mapping
;
Crosses, Genetic
;
Female
;
GTP-Binding Proteins/chemistry/*genetics/*physiology
;
Gene Expression
;
Genes
;
In Situ Hybridization
;
Male
;
Mice
;
Mice, Neurologic Mutants
;
Molecular Sequence Data
;
*Mutation
;
Nerve Degeneration/*genetics
;
Nerve Regeneration
;
Neurons/metabolism
;
Phenotype
;
Purkinje Cells/cytology/*physiology
;
RNA, Messenger/genetics/metabolism
;
Retina/metabolism
;
*Serine-Type D-Ala-D-Ala Carboxypeptidase
;
Spermatogenesis
;
Testis/metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
Permalink