ALBERT

Description: 〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4138491/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4138491/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉H3Africa Consortium -- Rotimi, Charles -- Abayomi, Akin -- Abimiku, Alash'le -- Adabayeri, Victoria May -- Adebamowo, Clement -- Adebiyi, Ezekiel -- Ademola, Adebowale D -- Adeyemo, Adebowale -- Adu, Dwomoa -- Affolabi, Dissou -- Agongo, Godfred -- Ajayi, Samuel -- Akarolo-Anthony, Sally -- Akinyemi, Rufus -- Akpalu, Albert -- Alberts, Marianne -- Alonso Betancourt, Orlando -- Alzohairy, Ahmed Mansour -- Ameni, Gobena -- Amodu, Olukemi -- Anabwani, Gabriel -- Andersen, Kristian -- Arogundade, Fatiu -- Arulogun, Oyedunni -- Asogun, Danny -- Bakare, Rasheed -- Balde, Naby -- Baniecki, Mary Lynn -- Beiswanger, Christine -- Benkahla, Alia -- Bethke, Lara -- Boehnke, Micheal -- Boima, Vincent -- Brandful, James -- Brooks, Andrew I -- Brosius, Frank C -- Brown, Chester -- Bucheton, Bruno -- Burke, David T -- Burnett, Barrington G -- Carrington-Lawrence, Stacy -- Carstens, Nadia -- Chisi, John -- Christoffels, Alan -- Cooper, Richard -- Cordell, Heather -- Crowther, Nigel -- Croxton, Talishiea -- de Vries, Jantina -- Derr, Leslie -- Donkor, Peter -- Doumbia, Seydou -- Duncanson, Audrey -- Ekem, Ivy -- El Sayed, Ahmed -- Engel, Mark E -- Enyaru, John C K -- Everett, Dean -- Fadlelmola, Faisal M -- Fakunle, Eyitayo -- Fischbeck, Kenneth H -- Fischer, Anne -- Folarin, Onikepe -- Gamieldien, Junaid -- Garry, Robert F -- Gaseitsiwe, Simani -- Gbadegesin, Rasheed -- Ghansah, Anita -- Giovanni, Maria -- Goesbeck, Parham -- Gomez-Olive, F Xavier -- Grant, Donald S -- Grewal, Ravnit -- Guyer, Mark -- Hanchard, Neil A -- Happi, Christian T -- Hazelhurst, Scott -- Hennig, Branwen J -- Hertz-, Christiane -- Fowler -- Hide, Winston -- Hilderbrandt, Friedhelm -- Hugo-Hamman, Christopher -- Ibrahim, Muntaser E -- James, Regina -- Jaufeerally-Fakim, Yasmina -- Jenkins, Carolyn -- Jentsch, Ute -- Jiang, Pan-Pan -- Joloba, Moses -- Jongeneel, Victor -- Joubert, Fourie -- Kader, Mukthar -- Kahn, Kathleen -- Kaleebu, Pontiano -- Kapiga, Saidi H -- Kassim, Samar Kamal -- Kasvosve, Ishmael -- Kayondo, Jonathan -- Keavney, Bernard -- Kekitiinwa, Adeodata -- Khan, Sheik Humarr -- Kimmel, Paul -- King, Mary-Claire -- Kleta, Robert -- Koffi, Mathurin -- Kopp, Jeffrey -- Kretzler, Matthias -- Kumuthini, Judit -- Kyobe, Samuel -- Kyobutungi, Catherine -- Lackland, Daniel T -- Lacourciere, Karen A -- Landoure, Guida -- Lawlor, Rita -- Lehner, Thomas -- Lesosky, Maia -- Levitt, Naomi -- Littler, Katherine -- Lombard, Zane -- Loring, Jeanne F -- Lyantagaye, Sylvester -- Macleod, Annette -- Madden, Ebony B -- Mahomva, Chengetai R -- Makani, Julie -- Mamven, Manmak -- Marape, Marape -- Mardon, Graeme -- Marshall, Patricia -- Martin, Darren P -- Masiga, Daniel -- Mason, Robin -- Mate-Kole, Michael -- Matovu, Enock -- Mayige, Mary -- Mayosi, Bongani M -- Mbanya, Jean Claude -- McCurdy, Sheryl A -- McCarthy, Mark I -- McIlleron, Helen -- Mc'Ligeyo, S O -- Merle, Corrine -- Mocumbi, Ana Olga -- Mondo, Charles -- Moran, John V -- Motala, Ayesha -- Moxey-Mims, Marva -- Mpoloka, Wata Sununguko -- Msefula, Chisomo L -- Mthiyane, Thuli -- Mulder, Nicola -- Mulugeta, Gebregziab her -- Mumba, Dieuodonne -- Musuku, John -- Nagdee, Mo -- Nash, Oyekanmi -- Ndiaye, Daouda -- Nguyen, Anh Quynh -- Nicol, Mark -- Nkomazana, Oathokwa -- Norris, Shane -- Nsangi, Betty -- Nyarko, Alexander -- Nyirenda, Moffat -- Obe, Eileen -- Obiakor, Reginald -- Oduro, Abraham -- Ofori-Acquah, Solomon F -- Ogah, Okechukwu -- Ogendo, Stephen -- Ohene-Frempong, Kwaku -- Ojo, Akinlolu -- Olanrewaju, Timothy -- Oli, John -- Osafo, Charlotte -- Ouwe Missi Oukem-Boyer, Odile -- Ovbiagele, Bruce -- Owen, Andrew -- Owolabi, Mayowa Ojo -- Owolabi, Lukman -- Owusu-Dabo, Ellis -- Pare, Guillaume -- Parekh, Rulan -- Patterton, Hugh G -- Penno, Margaret B -- Peterson, Jane -- Pieper, Rembert -- Plange-Rhule, Jacob -- Pollak, Martin -- Puzak, Julia -- Ramesar, Rajkumar S -- Ramsay, Michele -- Rasooly, Rebekah -- Reddy, Shiksha -- Sabeti, Pardis C -- Sagoe, Kwamena -- Salako, Tunde -- Samassekou, Oumar -- Sandhu, Manjinder S -- Sankoh, Osman -- Sarfo, Fred Stephen -- Sarr, Marie -- Shaboodien, Gasnat -- Sidibe, Issa -- Simo, Gustave -- Simuunza, Martin -- Smeeth, Liam -- Sobngwi, Eugene -- Soodyall, Himla -- Sorgho, Hermann -- Sow Bah, Oumou -- Srinivasan, Sudha -- Stein, Dan J -- Susser, Ezra S -- Swanepoel, Carmen -- Tangwa, Godfred -- Tareila, Andrew -- Tastan Bishop, Ozlem -- Tayo, Bamidele -- Tiffin, Nicki -- Tinto, Halidou -- Tobin, Ekaete -- Tollman, Stephen Meir -- Traore, Mahamadou -- Treadwell, Marsha J -- Troyer, Jennifer -- Tsimako-Johnstone, Masego -- Tukei, Vincent -- Ulasi, Ifeoma -- Ulenga, Nzovu -- van Rooyen, Beverley -- Wachinou, Ablo Prudence -- Waddy, Salina P -- Wade, Alisha -- Wayengera, Misaki -- Whitworth, James -- Wideroff, Louise -- Winkler, Cheryl A -- Winnicki, Sarah -- Wonkam, Ambroise -- Yewondwos, Mengistu -- sen, Tadase -- Yozwiak, Nathan -- Zar, Heather -- 085349/Wellcome Trust/United Kingdom -- 095009/Wellcome Trust/United Kingdom -- 095201/Wellcome Trust/United Kingdom -- 098504/Wellcome Trust/United Kingdom -- 104111/Wellcome Trust/United Kingdom -- MC_U123292700/Medical Research Council/United Kingdom -- P20 MD006899/MD/NIMHD NIH HHS/ -- R01 AI104621/AI/NIAID NIH HHS/ -- RG/08/012/25941/British Heart Foundation/United Kingdom -- U01 HG007044/HG/NHGRI NIH HHS/ -- U41 HG006941/HG/NHGRI NIH HHS/ -- U54 AI110398/AI/NIAID NIH HHS/ -- U54 HG006938/HG/NHGRI NIH HHS/ -- U54 HG006939/HG/NHGRI NIH HHS/ -- U54 HG007479/HG/NHGRI NIH HHS/ -- UH2 HG007051/HG/NHGRI NIH HHS/ -- New York, N.Y. -- Science. 2014 Jun 20;344(6190):1346-8. doi: 10.1126/science.1251546.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24948725" target="_blank"〉PubMed〈/a〉

Description: SOX9 encodes a transcription factor that governs cell fate specification throughout development and tissue homeostasis. Elevated SOX9 is implicated in the genesis and progression of human tumors by increasing cell proliferation and epithelial-mesenchymal transition. We found that in response to UV irradiation or genotoxic chemotherapeutics, SOX9 is actively degraded in various cancer types and in normal epithelial cells, through a pathway independent of p53, ATM, ATR and DNA-PK. SOX9 is phosphorylated by GSK3β, facilitating the binding of SOX9 to the F-box protein FBW7α, an E3 ligase that functions in the DNA damage response pathway. The binding of FBW7α to the SOX9 K2 domain at T236-T240 targets SOX9 for subsequent ubiquitination and proteasomal destruction. Exogenous overexpression of SOX9 after genotoxic stress increases cell survival. Our findings reveal a novel regulatory mechanism for SOX9 stability and uncover a unique function of SOX9 in the cellular response to DNA damage. This new mechanism underlying a FBW7-SOX9 axis in cancer could have implications in therapy resistance.

Description: The function of the N-methyl-D-aspartate (NMDA)-preferring glutamate receptor can be regulated by extracellular pH, a process that may be important during ischemia in the brain or during seizures. Protons inhibit NMDA receptor function by 50 percent at pH 7.3 through interactions with the NR1 subunit, and both polyamines and NR1 exon 5 potentiate receptor function through relief of the tonic proton inhibition present at physiological pH. A single amino acid (lysine 211) was identified that mediates the effects of exon 5 in the rat brain. Electroneutral substitutions at this position restored pH sensitivity and, consequently, polyamine relief of tonic inhibition. This effect, together with the structural similarities between polyamines and the surface loop encoded by exon 5, suggest that exon 5 may act as a tethered pH-sensitive constitutive modulator of NMDA receptor function.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Traynelis, S F -- Hartley, M -- Heinemann, S F -- NS08549/NS/NINDS NIH HHS/ -- NS28709/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1995 May 12;268(5212):873-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pharmacology, Emory University, Atlanta, GA 30322, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7754371" target="_blank"〉PubMed〈/a〉

Description: Critical measurements for understanding accretion and the dust/gas ratio in the solar nebula, where planets were forming 4.5 billion years ago, are being obtained by the GIADA (Grain Impact Analyser and Dust Accumulator) experiment on the European Space Agency's Rosetta spacecraft orbiting comet 67P/Churyumov-Gerasimenko. Between 3.6 and 3.4 astronomical units inbound, GIADA and OSIRIS (Optical, Spectroscopic, and Infrared Remote Imaging System) detected 35 outflowing grains of mass 10(-10) to 10(-7) kilograms, and 48 grains of mass 10(-5) to 10(-2) kilograms, respectively. Combined with gas data from the MIRO (Microwave Instrument for the Rosetta Orbiter) and ROSINA (Rosetta Orbiter Spectrometer for Ion and Neutral Analysis) instruments, we find a dust/gas mass ratio of 4 +/- 2 averaged over the sunlit nucleus surface. A cloud of larger grains also encircles the nucleus in bound orbits from the previous perihelion. The largest orbiting clumps are meter-sized, confirming the dust/gas ratio of 3 inferred at perihelion from models of dust comae and trails.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rotundi, Alessandra -- Sierks, Holger -- Della Corte, Vincenzo -- Fulle, Marco -- Gutierrez, Pedro J -- Lara, Luisa -- Barbieri, Cesare -- Lamy, Philippe L -- Rodrigo, Rafael -- Koschny, Detlef -- Rickman, Hans -- Keller, Horst Uwe -- Lopez-Moreno, Jose J -- Accolla, Mario -- Agarwal, Jessica -- A'Hearn, Michael F -- Altobelli, Nicolas -- Angrilli, Francesco -- Barucci, M Antonietta -- Bertaux, Jean-Loup -- Bertini, Ivano -- Bodewits, Dennis -- Bussoletti, Ezio -- Colangeli, Luigi -- Cosi, Massimo -- Cremonese, Gabriele -- Crifo, Jean-Francois -- Da Deppo, Vania -- Davidsson, Bjorn -- Debei, Stefano -- De Cecco, Mariolino -- Esposito, Francesca -- Ferrari, Marco -- Fornasier, Sonia -- Giovane, Frank -- Gustafson, Bo -- Green, Simon F -- Groussin, Olivier -- Grun, Eberhard -- Guttler, Carsten -- Herranz, Miguel L -- Hviid, Stubbe F -- Ip, Wing -- Ivanovski, Stavro -- Jeronimo, Jose M -- Jorda, Laurent -- Knollenberg, Joerg -- Kramm, Rainer -- Kuhrt, Ekkehard -- Kuppers, Michael -- Lazzarin, Monica -- Leese, Mark R -- Lopez-Jimenez, Antonio C -- Lucarelli, Francesca -- Lowry, Stephen C -- Marzari, Francesco -- Epifani, Elena Mazzotta -- McDonnell, J Anthony M -- Mennella, Vito -- Michalik, Harald -- Molina, Antonio -- Morales, Rafael -- Moreno, Fernando -- Mottola, Stefano -- Naletto, Giampiero -- Oklay, Nilda -- Ortiz, Jose L -- Palomba, Ernesto -- Palumbo, Pasquale -- Perrin, Jean-Marie -- Rodriguez, Julio -- Sabau, Lola -- Snodgrass, Colin -- Sordini, Roberto -- Thomas, Nicolas -- Tubiana, Cecilia -- Vincent, Jean-Baptiste -- Weissman, Paul -- Wenzel, Klaus-Peter -- Zakharov, Vladimir -- Zarnecki, John C -- New York, N.Y. -- Science. 2015 Jan 23;347(6220):aaa3905. doi: 10.1126/science.aaa3905.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Istituto di Astrofisica e Planetologia Spaziali, Istituto Nazionale di Astrofisica (INAF), Via Fosso del Cavaliere, 100, 0133 Rome, Italy. Universita degli Studi di Napoli "Parthenope," Dipartimento di Scienze e Tecnologie, CDN IC4, 80143 Naples, Italy. rotundi@uniparthenope.it. ; Max-Planck-Institut fur Sonnensystemforschung, Justus-von-Liebig-Weg, 3, 37077 Gottingen, Germany. ; Istituto di Astrofisica e Planetologia Spaziali, Istituto Nazionale di Astrofisica (INAF), Via Fosso del Cavaliere, 100, 0133 Rome, Italy. ; Osservatorio Astronomico, INAF, Via Tiepolo 11, 34143 Trieste, Italy. ; Instituto de Astrofisica de Andalucia, Consejo Superior de Investigaciones Cientificas (CSIC), P.O. Box 3008, 18080 Granada, Spain. ; Department of Physics and Astronomy, Padova University, Vicolo dell'Osservatorio 3, 35122 Padova, Italy. ; Laboratoire d'Astrophysique de Marseille, UMR 7326, CNRS and Aix-Marseille Universite, 13388 Marseille, France. ; Centro de Astrobiologia (Instituto Nacional de Tecnica Aerospacial-CSIC), 28691 Villanueva de la Canada, Madrid, Spain. International Space Science Institute, Hallerstrasse 6, CH-3012 Bern, Switzerland. ; Scientific Support Office, European Space Agency, 2201 Noordwijk, Netherlands. ; Department of Physics and Astronomy, Uppsala University, Box 516, 75120 Uppsala, Sweden. Polish Academy of Sciences Space Research Center, Bartycka 18A, PL-00716 Warszawa, Poland. ; Institute for Geophysics and Extraterrestrial Physics, Technische Universitat Braunschweig, Braunschweig 38106, Germany. ; Istituto di Astrofisica e Planetologia Spaziali, Istituto Nazionale di Astrofisica (INAF), Via Fosso del Cavaliere, 100, 0133 Rome, Italy. Universita degli Studi di Napoli "Parthenope," Dipartimento di Scienze e Tecnologie, CDN IC4, 80143 Naples, Italy. ; Department of Astronomy, University of Maryland, College Park, MD 20742-2421, USA. ; European Space Agency (ESA)-European Space Astronomy Center (ESAC), Camino Bajo del Castillo, s/n, 28692 Villanueva de la Canada, Madrid, Spagna. ; Department of Mechanical Engineering, University of Padova, via Venezia 1, 35131 Padova, Italy. ; Laboratoire d'Etudes Spatiales et d'Instrumentation en Astrophysique, Observatoire de Paris, CNRS, Universite Paris 06, Universite Paris-Diderot, 5 place Johannes Janssen, 92195 Meudon, France. ; Laboratoire Atmospheres, Milieux, Observations Spatiales, CNRS/Universite de Versailles Saint-Quentin-en-Yvelines/Institut Pierre-Simon Laplace, 11 boulevard d'Alembert, 78280 Guyancourt, France. ; University of Padova, Centro Interdipartimentale di Studi e Attivita Spaziali (CISAS), via Venezia 15, 35100 Padova, Italy. ; Universita degli Studi di Napoli "Parthenope," Dipartimento di Scienze e Tecnologie, CDN IC4, 80143 Naples, Italy. ; ESA, European Space Research and Technology Centre (ESTEC), Keplerlaan 1, 2201 AZ Noordwijk, Netherlands. ; Selex-ES, Via Albert Einstein, 35, 50013 Campi Bisenzio, Firenze, Italy. ; Osservatorio Astronomico di Padova, INAF, Vicolo dell'Osservatorio 5, 35122 Padova, Italy. ; Consiglio Nazionale delle Ricerche-Istituto di Fotonica e Nanotecnologie-Unita Operativa di Supporto Padova LUXOR, via Trasea 7, 35131 Padova, Italy. ; Department of Physics and Astronomy, Uppsala University, Box 516, 75120 Uppsala, Sweden. ; Universita di Trento, via Mesiano, 77, 38100 Trento, Italy. ; Osservatorio Astronomico di Capodimonte, INAF, Salita Moiariello, 16, 80133 Naples, Italy. ; Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA. ; University of Florida, Gainesville, FL 32611, USA. ; Planetary and Space Sciences, Department of Physical Sciences, The Open University, Milton Keynes MK7 6AA, UK. ; Max-Planck-Institut fuer Kernphysik, Saupfercheckweg 1, 69117 Heidelberg, Germany. ; Institute of Planetary Research, Deutsches Zentrum fur Luft- und Raumfahrt (DLR), Rutherfordstrasse 2, 12489 Berlin, Germany. ; Institute for Space Science, National Central University, 300 Chung Da Road, 32054 Chung-Li, Taiwan. ; The University of Kent, School of Physical Sciences, Canterbury, Kent CT2 7NZ, UK. ; Department of Physics, University of Padova, 35131 Padova, Italy. ; Planetary and Space Sciences, Department of Physical Sciences, The Open University, Milton Keynes MK7 6AA, UK. The University of Kent, School of Physical Sciences, Canterbury, Kent CT2 7NZ, UK. Unispacekent, Canterbury CT2 8EF, UK. ; Institut fur Datentechnik und Kommunikationsnetze, 38106 Braunschweig, Germany. ; Departamento de Fisica Aplicada, Universidad de Granada, Facultad de Ciencias, Avenida Severo Ochoa, s/n, 18071 Granada, Spain. ; Department of Information Engineering, Padova University, via Gradenigo 6, 35131 Padova, Italy. ; Laboratoire Atmospheres, Milieux, Observations Spatiales, CNRS/Universite de Versailles Saint-Quentin-en-Yvelines/Institut Pierre-Simon Laplace, 11 boulevard d'Alembert, 78280 Guyancourt, France. Observatoire de Haute Provence OSU Pytheas UMS 2244 CNRS-AMU, 04870 Saint Michel l'Observatoire, France. ; Instituto Nacional de Tecnica Aeroespacial, Carretera de Ajalvir, p.k. 4, 28850 Torrejon de Ardoz, Madrid, Spain. ; Max-Planck-Institut fur Sonnensystemforschung, Justus-von-Liebig-Weg, 3, 37077 Gottingen, Germany. Planetary and Space Sciences, Department of Physical Sciences, The Open University, Milton Keynes MK7 6AA, UK. ; Physikalisches Institut, Sidlerstrasse 5, University of Bern, 3012 Bern, Switzerland. ; Planetary Science Section, Jet Propulsion Laboratory, 4800 Oak Grove Drive, Pasadena, CA 91109, USA. ; International Space Science Institute, Hallerstrasse 6, CH-3012 Bern, Switzerland. Planetary and Space Sciences, Department of Physical Sciences, The Open University, Milton Keynes MK7 6AA, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25613898" target="_blank"〉PubMed〈/a〉

Description: On 2016 Feb 19, nine Rosetta instruments serendipitously observed an outburst of gas and dust from the nucleus of comet 67P/Churyumov-Gerasimenko. Among these instruments were cameras and spectrometers ranging from UV over visible to microwave wavelengths, in situ gas, dust and plasma instruments, and one dust collector. At 09:40 a dust cloud developed at the edge of an image in the shadowed region of the nucleus. Over the next two hours the instruments recorded a signature of the outburst that significantly exceeded the background. The enhancement ranged from 50 per cent of the neutral gas density at Rosetta to factors 〉100 of the brightness of the coma near the nucleus. Dust related phenomena (dust counts or brightness due to illuminated dust) showed the strongest enhancements (factors 〉10). However, even the electron density at Rosetta increased by a factor 3 and consequently the spacecraft potential changed from ~–16 V to –20 V during the outburst. A clear sequence of events was observed at the distance of Rosetta (34 km from the nucleus): within 15 min the Star Tracker camera detected fast particles (~25 m s –1 ) while 100 μm radius particles were detected by the GIADA dust instrument ~1 h later at a speed of 6 m s –1 . The slowest were individual mm to cm sized grains observed by the OSIRIS cameras. Although the outburst originated just outside the FOV of the instruments, the source region and the magnitude of the outburst could be determined.