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  • Nature Publishing Group  (170)
  • American Association for the Advancement of Science (AAAS)  (90)
  • 1
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    Regulation of mitochondrial iron accumulation by Yfh1p, a putative homolog of frataxin (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-06-13
    Description: The gene responsible for Friedreich's ataxia, a disease characterized by neurodegeneration and cardiomyopathy, has recently been cloned and its product designated frataxin. A gene in Saccharomyces cerevisiae was characterized whose predicted protein product has high sequence similarity to the human frataxin protein. The yeast gene (yeast frataxin homolog, YFH1) encodes a mitochondrial protein involved in iron homeostasis and respiratory function. Human frataxin also was shown to be a mitochondrial protein. Characterizing the mechanism by which YFH1 regulates iron homeostasis in yeast may help to define the pathologic process leading to cell damage in Friedreich's ataxia.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Babcock, M -- de Silva, D -- Oaks, R -- Davis-Kaplan, S -- Jiralerspong, S -- Montermini, L -- Pandolfo, M -- Kaplan, J -- DK30534/DK/NIDDK NIH HHS/ -- DK49219/DK/NIDDK NIH HHS/ -- NS34192/NS/NINDS NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1997 Jun 13;276(5319):1709-12.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pathology, School of Medicine, University of Utah, Salt Lake City, UT 84132, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9180083" target="_blank"〉PubMed〈/a〉
    Keywords: Biological Transport ; Carrier Proteins/metabolism ; Cell Membrane/metabolism ; *Ceruloplasmin ; Cytosol/metabolism ; Friedreich Ataxia/metabolism ; Fungal Proteins/genetics/*metabolism ; Genes, Fungal ; Genetic Complementation Test ; Homeostasis ; Humans ; Iron/*metabolism ; *Iron-Binding Proteins ; Membrane Transport Proteins/metabolism ; Mitochondria/*metabolism ; Oxidative Stress ; Oxidoreductases/metabolism ; Phosphotransferases (Alcohol Group Acceptor)/metabolism ; Recombinant Fusion Proteins/metabolism ; Saccharomyces cerevisiae/genetics/growth & development/*metabolism ; *Saccharomyces cerevisiae Proteins ; Transformation, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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    PAPER CURRENT
  • 2
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    Early anthropogenic transformation of the Danube-Black Sea system (2012)
    Nature Publishing Group
    Details
    Publication Date: 2022-05-25
    Description: © The Author(s), 2012. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Scientific Reports 2 (2012): 582, doi:10.1038/srep00582.
    Description: Over the last century humans have altered the export of fluvial materials leading to significant changes in morphology, chemistry, and biology of the coastal ocean. Here we present sedimentary, paleoenvironmental and paleogenetic evidence to show that the Black Sea, a nearly enclosed marine basin, was affected by land use long before the changes of the Industrial Era. Although watershed hydroclimate was spatially and temporally variable over the last ~3000 years, surface salinity dropped systematically in the Black Sea. Sediment loads delivered by Danube River, the main tributary of the Black Sea, significantly increased as land use intensified in the last two millennia, which led to a rapid expansion of its delta. Lastly, proliferation of diatoms and dinoflagellates over the last five to six centuries, when intensive deforestation occurred in Eastern Europe, points to an anthropogenic pulse of river-borne nutrients that radically transformed the food web structure in the Black Sea.
    Description: This study was supported by grants OISE 0637108, EAR 0952146, OCE 0602423 and OCE 0825020 from the National Science Foundation and grants from the Woods Hole Oceanographic Institution.
    Repository Name: Woods Hole Open Access Server
    Type: Article
    Format: application/pdf
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  • 3
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    Coral reef soundscapes may not be detectable far from the reef (2016)
    Nature Publishing Group
    Details
    Publication Date: 2022-05-26
    Description: © The Author(s), 2016. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Scientific Reports 6 (2016): 31862, doi:10.1038/srep31862.
    Description: Biological sounds produced on coral reefs may provide settlement cues to marine larvae. Sound fields are composed of pressure and particle motion, which is the back and forth movement of acoustic particles. Particle motion (i.e., not pressure) is the relevant acoustic stimulus for many, if not most, marine animals. However, there have been no field measurements of reef particle motion. To address this deficiency, both pressure and particle motion were recorded at a range of distances from one Hawaiian coral reef at dawn and mid-morning on three separate days. Sound pressure attenuated with distance from the reef at dawn. Similar trends were apparent for particle velocity but with considerable variability. In general, average sound levels were low and perhaps too faint to be used as an orientation cue except very close to the reef. However, individual transient sounds that exceeded the mean values, sometimes by up to an order of magnitude, might be detectable far from the reef, depending on the hearing abilities of the larva. If sound is not being used as a long-range cue, it might still be useful for habitat selection or other biological activities within a reef.
    Description: This work was funded by the Woods Hole Oceanographic Institution Ocean Ventures Fund, the PADI Foundation, the Woods Hole Oceanographic Institution Access To The Sea program, and the National Science Foundation grant OCE-1536782.
    Repository Name: Woods Hole Open Access Server
    Type: Article
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  • 4
    Electronic Resource
    Electronic Resource
    It takes a village to grow a tissue (2005)
    [s.l.] : Nature Publishing Group
    Nature biotechnology 23 (2005), S. 1237-1239 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Tissue engineering aims to grow tissue replacements by combining cells and matrices under defined laboratory conditions. The shortage of donor tissues and organs and the increasing demand for tissue repair from an aging population have catalyzed research in the field. A US National Institutes of ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nbt1005-1237
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  • 5
    Electronic Resource
    Electronic Resource
    Age of the ΔF508 cystic fibrosis mutation (1994)
    [s.l.] : Nature Publishing Group
    Nature genetics 8 (1994), S. 216-216 
    Details
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Sir—In a recent Nature Genetics paper, Morral et al. suggested that the ΔF508 mutation, responsible for 70% of the cases of cystic fibrosis (CF), is at least 2,600 generations old. This is far greater than the usually accepted figure of a few hundred generations2. Morral et al. ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/ng1194-216a
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  • 6
    Electronic Resource
    Electronic Resource
    Licensing research tool patents (2002)
    [s.l.] : Nature Publishing Group
    Nature biotechnology 20 (2002), S. 945-947 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Research tool patents typically claim methods or compositions used to discover novel, biologically important compounds and therapeutics. Patentees often try to maximize the rewards of their innovation by conditioning licenses to research tool patents on royalties from sales of commercial products ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nbt0902-945
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  • 7
    Electronic Resource
    Electronic Resource
    To treat or not to treat? (1998)
    [s.l.] : Nature Publishing Group
    Nature medicine 4 (1998), S. 664-665 
    Details
    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] UNLIKE LOVE, HERPES is forever, but the question remains what to do about it. Episodic outbreaks of genital herpes lesions caused by herpes simplex virus type 2 (HSV-2) can be treated with acyclovir, a drug that also offers benefits if used pro-phylactically. Unfortunately, widespread treatment ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nm0698-664
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  • 8
    Electronic Resource
    Electronic Resource
    A recurrent mutation in the BMP type I receptor ACVR1 causes inherited and sporadic fibrodysplasia ossificans progressiva (2006)
    [s.l.] : Nature Publishing Group
    Nature genetics 38 (2006), S. 525-527 
    Details
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Fibrodysplasia ossificans progressiva (FOP) is a rare autosomal dominant disorder of skeletal malformations and progressive extraskeletal ossification. We mapped FOP to chromosome 2q23-24 by linkage analysis and identified an identical heterozygous mutation (617G → A; R206H) in the ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/ng1783
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  • 9
    Electronic Resource
    Electronic Resource
    Antibiotic resistance - what can we do? (1998)
    [s.l.] : Nature Publishing Group
    Nature medicine 4 (1998), S. 545-546 
    Details
    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] The incidence of resistance to antibacterial agents has increased at an alarming rate in recent years and is now a major global public health problem. Continued growth in the use of antibiotics is likely to lead to further increases in resistance, and several antibacterial agents are expected to ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nm0598-545
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  • 10
    Electronic Resource
    Electronic Resource
    Transient renewal of thymopoiesis in HIV-infected human thymic implants following antiviral therapy (1997)
    [s.l.] : Nature Publishing Group
    Nature medicine 3 (1997), S. 1102-1109 
    Details
    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Stem cell gene therapy strategies for AIDS require that differentiation-inducing stromal elements of HIV-infected individuals remain functionally intact to support the maturation of exogenous progenitor cells into mature CD4+ cells. To investigate the feasibility of stem cell reconstitution ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nm1097-1102
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