Publication Date:
1982-01-08
Description:
With an alpha-galactosidase, B erythrocytes can be converted to blood group O under conditions that neither impair their viability in vitro nor affect their ability to survive normally after transfusion to individuals of groups O, A, and B. Such an approach has the potential for producing enzymatically converted group O cells for use in transfusion therapy. It should also be possible to convert A cells to group O by using the appropriate alpha-N-acetylgalactosaminidase.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Goldstein, J -- Siviglia, G -- Hurst, R -- Lenny, L -- Reich, L -- New York, N.Y. -- Science. 1982 Jan 8;215(4529):168-70.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6274021" target="_blank"〉PubMed〈/a〉
Keywords:
*ABO Blood-Group System
;
Blood Transfusion
;
Erythrocyte Aging
;
Erythrocyte Membrane/immunology
;
Galactosidases/*pharmacology
;
Glycophorin/metabolism
;
Humans
;
alpha-Galactosidase/*pharmacology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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