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  • 1
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    Insulin staining of ES cell progeny from insulin uptake (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2003-01-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rajagopal, Jayaraj -- Anderson, William J -- Kume, Shoen -- Martinez, Olga I -- Melton, Douglas A -- New York, N.Y. -- Science. 2003 Jan 17;299(5605):363.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular and Cellular Biology, Howard Hughes Medical Institute, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12532008" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antibodies/immunology ; Apoptosis ; Cell Differentiation ; Cell Line ; Embryo, Mammalian/*cytology ; Humans ; Insulin/*analysis/genetics/immunology/*metabolism ; Islets of Langerhans/*cytology/metabolism ; Mice ; Microscopy, Confocal ; RNA, Messenger/genetics/metabolism ; Reverse Transcriptase Polymerase Chain Reaction ; Stem Cells/*cytology/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Role of inositol 1,4,5-trisphosphate receptor in ventral signaling in Xenopus embryos (1998)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1998-01-07
    Description: The inositol 1,4,5-trisphosphate (IP3) receptor is a calcium ion channel involved in the release of free Ca2+ from intracellular stores. For analysis of the role of IP3-induced Ca2+ release (IICR) on patterning of the embryonic body, monoclonal antibodies that inhibit IICR were produced. Injection of these blocking antibodies into the ventral part of early Xenopus embryos induced modest dorsal differentiation. A close correlation between IICR blocking potencies and ectopic dorsal axis induction frequency suggests that an active IP3-Ca2+ signal may participate in the modulation of ventral differentiation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kume, S -- Muto, A -- Inoue, T -- Suga, K -- Okano, H -- Mikoshiba, K -- New York, N.Y. -- Science. 1997 Dec 12;278(5345):1940-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Mikoshiba Calciosignal Net Project, Exploratory Research for Advanced Technology (ERATO), Japan Science and Technology Corporation (JST), 2-9-3 Shimo-Meguro, Meguro-ku, Tokyo 153, Japan. skume@ims.u-tokyo.ac.jp〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9395395" target="_blank"〉PubMed〈/a〉
    Keywords: Activins ; Animals ; Antibodies, Blocking ; Antibodies, Monoclonal ; *Body Patterning ; Calcium/*metabolism ; Calcium Channels/immunology/*metabolism ; Cell Differentiation ; Embryo, Nonmammalian/*metabolism ; Embryonic Development ; Embryonic Induction ; Fibroblast Growth Factor 2/pharmacology ; Gastrula/metabolism ; Gene Expression Regulation, Developmental ; Inhibins/pharmacology ; Inositol 1,4,5-Trisphosphate/*metabolism ; Inositol 1,4,5-Trisphosphate Receptors ; Receptors, Cytoplasmic and Nuclear/immunology/*metabolism ; *Signal Transduction ; Xenopus
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Activation of the G protein Gq/11 through tyrosine phosphorylation of the alpha subunit (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-06-20
    Description: Various receptors coupled to the heterotrimeric guanine nucleotide-binding protein Gq/11 stimulate formation of inositol-1,4,5-trisphosphate (IP3). Activation of these receptors also induces protein tyrosine phosphorylation. Formation of IP3 in response to stimulated receptors that couple to Gq/11 was blocked by protein tyrosine kinase inhibitors. These inhibitors appeared to act before activation of Gq/11. Moreover, stimulation of receptors coupled to Gq/11 induced phosphorylation on a tyrosine residue (Tyr356) of the Galphaq/11 subunit, and this tyrosine phosphorylation event was essential for Gq/11 activation. Tyrosine phosphorylation of Galphaq/11 induced changes in its interaction with receptors. Therefore, tyrosine phosphorylation of Galphaq/11 appears to regulate the activation of Gq/11 protein.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Umemori, H -- Inoue, T -- Kume, S -- Sekiyama, N -- Nagao, M -- Itoh, H -- Nakanishi, S -- Mikoshiba, K -- Yamamoto, T -- New York, N.Y. -- Science. 1997 Jun 20;276(5320):1878-81.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Oncology, Institute of Medical Science, University of Tokyo, Tokyo 108, Japan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9188537" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; CHO Cells ; Calcium/metabolism ; Carbachol/pharmacology ; Cell Line ; Cricetinae ; Enzyme Inhibitors/pharmacology ; GTP-Binding Proteins/*metabolism ; Genistein ; Inositol 1,4,5-Trisphosphate/metabolism ; Isoflavones/pharmacology ; Phosphorylation ; Phosphotyrosine/*metabolism ; Protein-Tyrosine Kinases/antagonists & inhibitors/metabolism ; Receptors, Cholinergic/*metabolism ; Receptors, Metabotropic Glutamate/*metabolism ; Signal Transduction
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Synthesis of K2SiSi3O9 with silicon in 4- and 6-coordination (1975)
    Mineralogical Society of Great Britain and Ireland
    Details
    Publication Date: 1975-12-01
    Description: SummaryTwo kinds of vitreous material with composition K2GeSi3O9 and K2Si4O9 were treated under conditions of high temperature and pressure. The X-ray diffraction patterns of the products were similar to that of K2TiSi3O9, which has the wadeite, K2ZrSi3O9, structure.A natural crystal of K-feldspar was also treated under the same conditions. The product was found to consist of three phases, coesite, kyanite, and the above-mentioned K2Si4O9. Since Zr ions in wadeite are in a 6-coordinated site, one-quarter of Si ions in K2Si4O9 are considered to be in 6-coordination. This is the first silicate in which Si ions occupy sites of 4- and 6-coordinations in one crystal at the same time.
    Print ISSN: 0026-461X
    Electronic ISSN: 1471-8022
    Topics: Geosciences
    Published by Mineralogical Society of Great Britain and Ireland
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  • 5
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    Synthesis of potassium manganese oxides under hydrothermal conditions (1974)
    Mineralogical Society of Great Britain and Ireland
    Details
    Publication Date: 1974-03-01
    Description: SummaryA 1 M solution of potassium permanganate was sealed in a gold capsule and was treated under conditions of temperature and pressure up to 800 °C and 2·5 kb. Different kinds of products were produced under different conditions of synthesis, and potassium manganate, birnessite, cryptomelane, hausmannite, manganosite, and a new phase appeared. The chemical composition of the new phase was determined as K2Mn4O9 and its X-ray powder diffraction pattern was indexed on a hexagonal cell with a 11·295 and c 21·870 Å.
    Print ISSN: 0026-461X
    Electronic ISSN: 1471-8022
    Topics: Geosciences
    Published by Mineralogical Society of Great Britain and Ireland
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  • 6
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    Synthesis of prismatic and tabular diamond crystals (1980)
    Mineralogical Society of Great Britain and Ireland
    Details
    Publication Date: 1980-03-01
    Description: SummaryWhen diamond is synthesized at conditions of comparatively high temperature and pressure, the nucleation rate is high, as is the growth rate of the nuclei. Consequently the product is usually an aggregate of crystals with dendritic or skeletal structure. In this study the presence of gold or silver as an additive mixed with a catalyst was found to have the effect of suppressing nucleation. When a homogeneous mixture of graphite, catalyst, and additive was treated at conditions where skeletons and dendrites were produced in the absence of additive, euhedral crystals of octahedra were formed. When a special cell assemblage for high pressure experiments, in which the graphite was placed inside a cylinder of catalyst coated with additive, was used, prismatic and tabular crystals were synthesized.
    Print ISSN: 0026-461X
    Electronic ISSN: 1471-8022
    Topics: Geosciences
    Published by Mineralogical Society of Great Britain and Ireland
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