ALBERT

All Library Books, journals and Electronic Records Telegrafenberg

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • Wiley  (11)
  • Oxford University Press  (5)
  • American Association for the Advancement of Science (AAAS)  (4)
  • Institute of Physics  (4)
  • The Royal Society  (1)
  • 1
    facet.materialart.
    Unknown
    CDK-mediated RNF4 phosphorylation regulates homologous recombination in S-phase (2015)
    Oxford University Press
    Details
    Publication Date: 2015-06-24
    Description: There are the two major pathways responsible for the repair of DNA double-strand breaks (DSBs): non-homologous end-joining (NHEJ) and homologous recombination (HR). NHEJ operates throughout the cell-cycle, while HR is primarily active in the S/G2 phases suggesting that there are cell cycle-specific mechanisms that regulate the balance between NHEJ and HR. Here we reported that CDK2 could phosphorylate RNF4 on T26 and T112 and enhance RNF4 E3 ligase activity, which is important for MDC1 degradation and proper HR repair during S phase. Mutation of the RNF4 phosphorylation sites results in MDC1 stabilization, which in turn compromised HR during S-phase. These results suggest that in addition to drive cell cycle progression, CDK also targets RNF4, which is involved in the regulatory network of DSBs repair.
    Print ISSN: 0305-1048
    Electronic ISSN: 1362-4962
    Topics: Biology
    Published by Oxford University Press
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 2
    facet.materialart.
    Unknown
    HERC2-USP20 axis regulates DNA damage checkpoint through Claspin (2014)
    Oxford University Press
    Details
    Publication Date: 2014-11-28
    Description: The DNA damage response triggers cell-cycle checkpoints, DNA repair and apoptosis using multiple post-translational modifications as molecular switches. However, how ubiquitination regulates ATR signaling in response to replication stress and single-strand break is still unclear. Here, we identified the deubiquitination enzyme (DUB) USP20 as a pivotal regulator of ATR-related DDR pathway. Through screening a panel of DUBs, we identified USP20 as critical for replication stress response. USP20 is phosphorylated by ATR, resulting in disassociation of the E3 ubiquitin ligase HERC2 from USP20 and USP20 stabilization. USP20 in turn deubiquitinates and stabilizes Claspin and enhances the activation of ATR-Chk1 signaling. These findings reveal USP20 to be a novel regulator of ATR-dependent DNA damage signaling.
    Print ISSN: 0305-1048
    Electronic ISSN: 1362-4962
    Topics: Biology
    Published by Oxford University Press
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 3
    facet.materialart.
    Unknown
    Strongly correlated quantum walks with a 12-qubit superconducting processor (2019)
    American Association for the Advancement of Science (AAAS)
    In: Science
    Details
    Publication Date: 2019
    Description: 〈p〉Quantum walks are the quantum analogs of classical random walks, which allow for the simulation of large-scale quantum many-body systems and the realization of universal quantum computation without time-dependent control. We experimentally demonstrate quantum walks of one and two strongly correlated microwave photons in a one-dimensional array of 12 superconducting qubits with short-range interactions. First, in one-photon quantum walks, we observed the propagation of the density and correlation of the quasiparticle excitation of the superconducting qubit and quantum entanglement between qubit pairs. Second, when implementing two-photon quantum walks by exciting two superconducting qubits, we observed the fermionization of strongly interacting photons from the measured time-dependent long-range anticorrelations, representing the antibunching of photons with attractive interactions. The demonstration of quantum walks on a quantum processor, using superconducting qubits as artificial atoms and tomographic readout, paves the way to quantum simulation of many-body phenomena and universal quantum computation.〈/p〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 4
    facet.materialart.
    Unknown
    Enhanced Solid-Phase Photocatalytic Degradation Activity of a Poly(vinyl chloride)-TiO2 Nanocomposite Film with Bismuth Oxyiodide (2011)
    Wiley
    Details
    Publication Date: 2011-04-20
    Description: A new type of photodegradable poly(vinyl chloride)-bismuth oxyiodide/TiO 2 (PVC-BiOI/TiO 2 ) nanocomposite film was prepared by embedding a nano-TiO 2 photocatalyst modified by BiOI into the commercial PVC plastic. The solid-phase photocatalytic degradation behavior of the as-prepared film was investigated in ambient air at room temperature under UV light irradiation, with the aid of UV-Vis spectroscopy, weight loss monitoring, scanning electron microscopy, and FT-IR spectroscopy. Compared to the PVC-TiO 2 nanocomposite film, the PVC-BiOI nanocomposite film and the pure PVC film, the PVC-BiOI/TiO 2 nanocomposite film exhibited a higher photocatalytic degradation activity. The optimal mass ratio of BiOI to TiO 2 was found to be 0.75 %. The weight loss rate of the PVC-BiOI/TiO 2 nanocomposite film reached 30.8 % after 336 h of irradiation, which is 1.5 times higher than that of the PVC-TiO 2 nanocomposite film under identical conditions. The solid-phase photocatalytic degradation mechanism of the nanocomposite films was briefly discussed. A new type of photodegradable PVC-BiOI/TiO 2 nanocomposite film was prepared. In comparison with the PVC-TiO 2 nanocomposite film, the PVC-BiOI nanocomposite film and the pure PVC film, the PVC-BiOI/TiO 2 nanocomposite film exhibited a higher solid-phase photocatalytic degradation activity.
    Print ISSN: 0930-7516
    Electronic ISSN: 1521-4125
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Published by Wiley
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 5
    facet.materialart.
    Unknown
    Replication protein A prevents promiscuous annealing between short sequence homologies: Implications for genome integrity (2014)
    Wiley
    In: BioEssays
    Details
    Publication Date: 2014-11-15
    Description: Replication protein A (RPA) is the main eukaryotic single-stranded DNA (ssDNA) binding protein, having essential roles in all DNA metabolic reactions involving ssDNA. RPA binds ssDNA with high affinity, thereby preventing the formation of secondary structures and protecting ssDNA from the action of nucleases, and directly interacts with other DNA processing proteins. Here, we discuss recent results supporting the idea that one function of RPA is to prevent annealing between short repeats that can lead to chromosome rearrangements by microhomology-mediated end joining or the formation of hairpin structures that are substrates for structure-selective nucleases. We suggest that replication fork catastrophe caused by depletion of RPA could result from cleavage of secondary structures by nucleases, and that failure to cleave hairpin structures formed at DNA ends could lead to gene amplification. These studies highlight the important role RPA plays in maintaining genome integrity. RPA binding to the ssDNA tailed intermediates that are formed during the repair of DNA double-strand breaks prevents annealing between short sequence homologies internal to the ends. When RPA is depleted from cells, or when its DNA binding activity is compromised, annealing between short repeats can lead to mutagenic microhomology-mediated end joining (MMEJ) or hairpin-capped ends.
    Print ISSN: 0265-9247
    Electronic ISSN: 1521-1878
    Topics: Biology , Medicine
    Published by Wiley
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 6
    facet.materialart.
    Unknown
    Inference of Markovian properties of molecular sequences from NGS data and applications to comparative genomics (2016)
    Oxford University Press
    Details
    Publication Date: 2016-03-26
    Description: Motivation : Next-generation sequencing (NGS) technologies generate large amounts of short read data for many different organisms. The fact that NGS reads are generally short makes it challenging to assemble the reads and reconstruct the original genome sequence. For clustering genomes using such NGS data, word-count based alignment-free sequence comparison is a promising approach, but for this approach, the underlying expected word counts are essential. A plausible model for this underlying distribution of word counts is given through modeling the DNA sequence as a Markov chain (MC). For single long sequences, efficient statistics are available to estimate the order of MCs and the transition probability matrix for the sequences. As NGS data do not provide a single long sequence, inference methods on Markovian properties of sequences based on single long sequences cannot be directly used for NGS short read data. Results: Here we derive a normal approximation for such word counts. We also show that the traditional Chi-square statistic has an approximate gamma distribution , using the Lander-Waterman model for physical mapping. We propose several methods to estimate the order of the MC based on NGS reads and evaluate those using simulations. We illustrate the applications of our results by clustering genomic sequences of several vertebrate and tree species based on NGS reads using alignment-free sequence dissimilarity measures. We find that the estimated order of the MC has a considerable effect on the clustering results , and that the clustering results that use a n MC of the estimated order give a plausible clustering of the species. Availability and implementation: Our implementation of the statistics developed here is available as R package ‘ NGS.MC ’ at http://www-rcf.usc.edu/~fsun/Programs/NGS-MC/NGS-MC.html . Contact: fsun@usc.edu Supplementary information: Supplementary data are available at Bioinformatics online.
    Print ISSN: 1367-4803
    Electronic ISSN: 1460-2059
    Topics: Biology , Computer Science , Medicine
    Published by Oxford University Press
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 7
    facet.materialart.
    Unknown
    Ethics. The ISSCR guidelines for human embryonic stem cell research (2007)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2007-02-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Daley, George Q -- Ahrlund Richter, Lars -- Auerbach, Jonathan M -- Benvenisty, Nissim -- Charo, R Alta -- Chen, Grace -- Deng, Hong-Kui -- Goldstein, Lawrence S -- Hudson, Kathy L -- Hyun, Insoo -- Junn, Sung Chull -- Love, Jane -- Lee, Eng Hin -- McLaren, Anne -- Mummery, Christine L -- Nakatsuji, Norio -- Racowsky, Catherine -- Rooke, Heather -- Rossant, Janet -- Scholer, Hans R -- Solbakk, Jan Helge -- Taylor, Patrick -- Trounson, Alan O -- Weissman, Irving L -- Wilmut, Ian -- Yu, John -- Zoloth, Laurie -- New York, N.Y. -- Science. 2007 Feb 2;315(5812):603-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Children's Hospital, Boston, Massachusetts, USA. george.daley@childrens.harvard.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17272706" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; Chimera ; *Embryo Research/ethics/legislation & jurisprudence ; Embryonic Development ; *Embryonic Stem Cells ; *Guidelines as Topic ; Humans ; Informed Consent ; International Cooperation ; Oocyte Donation/economics/ethics ; Pluripotent Stem Cells ; Societies, Scientific ; Tissue Donors/ethics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 8
    facet.materialart.
    Unknown
    Strongly correlated quantum walks with a 12-qubit superconducting processor (2019)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2019
    Description: 〈p〉Quantum walks are the quantum analogs of classical random walks, which allow simulating large-scale quantum many-body systems and realizing universal quantum computation without time-dependent control. We experimentally demonstrate quantum walks of one and two strongly correlated microwave photons in a 1D array of 12 superconducting qubits with short-range interactions. First, in one-photon quantum walks, we observed the propagation of the density and correlation of the quasi-particle excitation of the superconducting qubit, and quantum entanglement between qubit pairs. Second, when implementing two-photon quantum walks by exciting two superconducting qubits, we observed the fermionization of strongly interacting photons from the measured time-dependent long-range anticorrelations, representing the antibunching of photons with attractive interactions. The demonstration of quantum walks on a quantum processor, using superconducting qubits as artificial atoms and tomographic readout, paves the way to quantum simulation of many-body phenomena and universal quantum computation.〈/p〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Natural Sciences in General
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 9
    facet.materialart.
    Unknown
    Remote Magnetometry With Mesospheric Sodium Based on Gated Photon Counting (2019)
    Wiley
    Details
    Publication Date: 2019
    Description: Abstract Remote detection of geomagnetic fields in the mesosphere would provide a powerful tool for mapping and interpreting Earth's lithospheric magnetic fields, monitoring magnetic disturbances in conjunction with the aurora, and making long‐term measurements of ionospheric currents at polar regions. Based on gated photon counting and direct frequency sweep, a remote magnetometry scheme with precession of mesospheric sodium was demonstrated. The technique of gated photon counting has an advantage in background light suppression and has the potential to achieve altitude‐resolved magnetic field measurements with an optimized laser source. An intensity‐modulated laser beam was utilized to optically pump sodium atoms in the mesopause, and a ground‐based telescope collects fluorescent echoes to infer the magnetic field. The experiment was carried out at Lijiang observatory where we validated this technique and measured the geomagnetic field with a sensitivity of 849 nT/Hz1/2, which can be improved through further optimization.
    Print ISSN: 2169-9380
    Electronic ISSN: 2169-9402
    Topics: Geosciences , Physics
    Published by Wiley on behalf of American Geophysical Union (AGU).
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 10
    facet.materialart.
    Unknown
    Wave diffraction and resolution of mantle transition zone discontinuities in receiver function imaging (2015)
    Oxford University Press
    Details
    Publication Date: 2015-04-19
    Description: The structure of seismic discontinuities in the mantle transition zone at depths of about 400 and 670 km provides important constraints on mantle convection as the associated mineral phase transformations are sensitive to thermal perturbations. Teleseismic P -to- S receiver functions have been widely used to map the depths of the two discontinuities. In this study, we investigate the resolution of receiver functions in imaging topographic variations of the 400-km and 670-km discontinuities based on wave propagation simulations using a Spectral Element Method (SEM). We investigate wave diffraction effects on direct P waves as well as P -to- S converted waves by varying the length scale of topography of the two discontinuities. We observe strong wave diffractional effects in both P waves and teleseismic receiver functions at periods of ~10 to 20 s. Ray theory overpredicts traveltime anomalies by a factor of 2–5 when the topography length scale is about 400 km. In addition, ray-theoretical predictions are out of phase with measurements which indicates that locations of small-scale topographic variations can not be resolved using ray theory. The observed traveltime anomalies further reduce to 10–20 per cent of ray-theoretical predictions when the topography length scale reduces to about 200 km. We calculate 2-D boundary sensitivity kernels for direct P waves as well as receiver functions. In general, calculations based Born sensitivity kernels fit the ‘ground-truth’ SEM measurements very well. They account for wave diffraction effects as well as phase interactions such as P and pP waves arriving in P -wave coda. 3-D wavespeed structure in the upper mantle beneath seismic stations may introduce significant traveltime anomalies on P waves and transition zone receiver functions. We show that traveltime corrections at periods of about 10 to 20 s are frequency dependent when the size of the anomalies becomes less than 500 km.
    Keywords: Seismology
    Print ISSN: 0956-540X
    Electronic ISSN: 1365-246X
    Topics: Geosciences
    Published by Oxford University Press on behalf of The Deutsche Geophysikalische Gesellschaft (DGG) and the Royal Astronomical Society (RAS).
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...