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  • 1
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    Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells (2010)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2010-08-07
    Description: Although practiced clinically for more than 40 years, the use of hematopoietic stem cell (HSC) transplants remains limited by the ability to expand these cells ex vivo. An unbiased screen with primary human HSCs identified a purine derivative, StemRegenin 1 (SR1), that promotes the ex vivo expansion of CD34+ cells. Culture of HSCs with SR1 led to a 50-fold increase in cells expressing CD34 and a 17-fold increase in cells that retain the ability to engraft immunodeficient mice. Mechanistic studies show that SR1 acts by antagonizing the aryl hydrocarbon receptor (AHR). The identification of SR1 and AHR modulation as a means to induce ex vivo HSC expansion should facilitate the clinical use of HSC therapy.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3033342/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3033342/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Boitano, Anthony E -- Wang, Jian -- Romeo, Russell -- Bouchez, Laure C -- Parker, Albert E -- Sutton, Sue E -- Walker, John R -- Flaveny, Colin A -- Perdew, Gary H -- Denison, Michael S -- Schultz, Peter G -- Cooke, Michael P -- ES004869/ES/NIEHS NIH HHS/ -- ES007685/ES/NIEHS NIH HHS/ -- ES04699/ES/NIEHS NIH HHS/ -- P42 ES004699/ES/NIEHS NIH HHS/ -- P42 ES004699-24/ES/NIEHS NIH HHS/ -- R01 ES004869/ES/NIEHS NIH HHS/ -- R01 ES004869-23/ES/NIEHS NIH HHS/ -- R01 ES007685/ES/NIEHS NIH HHS/ -- R01 ES007685-11/ES/NIEHS NIH HHS/ -- New York, N.Y. -- Science. 2010 Sep 10;329(5997):1345-8. doi: 10.1126/science.1191536. Epub 2010 Aug 5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20688981" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antigens, CD/analysis ; Antigens, CD34/analysis ; Aryl Hydrocarbon Hydroxylases/genetics/metabolism ; Cell Count ; Cell Lineage ; Cell Proliferation ; Cells, Cultured ; Cytochrome P-450 CYP1B1 ; Cytokines/pharmacology ; Glycoproteins/analysis ; Hematopoiesis ; *Hematopoietic Stem Cell Transplantation ; Hematopoietic Stem Cells/cytology/drug effects/metabolism/*physiology ; Humans ; Mice ; Mice, Inbred NOD ; Mice, SCID ; Multipotent Stem Cells/cytology/drug effects/physiology ; Peptides/analysis ; Purines/*metabolism/*pharmacology ; Receptors, Aryl Hydrocarbon/*antagonists & inhibitors/metabolism ; Signal Transduction ; Small Molecule Libraries ; Species Specificity ; Tetrachlorodibenzodioxin/pharmacology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Open-slope, translational submarine landslide in a tectonically active volcanic continental margin (Licosa submarine landslide, southern Tyrrhenian Sea) (2018)
    Geological Society (of London)
    Details
    Publication Date: 2018-05-26
    Description: The southern Tyrrhenian continental margin is the product of Pliocene–Recent back-arc extension. An area of approximately 30 km 2 of gentle (about 1.5°) lower slope of the last glacial outer shelf sedimentary wedge in water depths of between 200 and 300 m failed between 14 and 11 ka BP. We approached the landslide by multibeam and sub-bottom profiler surveying, high-resolution multichannel seismics, and coring for stratigraphic and geotechnical purposes. With regard to a slope-stability analysis, we carried out an assessment of the stratigraphic and structural setting of the area of the Licosa landslide. This analysis revealed that the landslide detached along a marker bed that was composed of the tephra layer Y-5 ( c. 39 ka). Several previously unknown geological characteristics of the area are likely to have affected the slope stability. These are the basal erosion of the slope in the Licosa Channel, a high sedimentation rate in the sedimentary wedge, earthquake shaking, the volcanic ash nature of the detachment surface, subsurface gas/fluid migration, and lateral porewater flow from the depocentre of wedge to the base of the slope along the high-permeability ash layers. A newly discovered prominent structural discontinuity is identified as the fault whose activity may have triggered the landslide.
    Print ISSN: 0305-8719
    Electronic ISSN: 2041-4927
    Topics: Geosciences
    Published by Geological Society (of London)
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