Publication Date:
2011-08-20
Description:
Aneuploidy decreases cellular fitness, yet it is also associated with cancer, a disease of enhanced proliferative capacity. To investigate one mechanism by which aneuploidy could contribute to tumorigenesis, we examined the effects of aneuploidy on genomic stability. We analyzed 13 budding yeast strains that carry extra copies of single chromosomes and found that all aneuploid strains exhibited one or more forms of genomic instability. Most strains displayed increased chromosome loss and mitotic recombination, as well as defective DNA damage repair. Aneuploid fission yeast strains also exhibited defects in mitotic recombination. Aneuploidy-induced genomic instability could facilitate the development of genetic alterations that drive malignant growth in cancer.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3278960/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3278960/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sheltzer, Jason M -- Blank, Heidi M -- Pfau, Sarah J -- Tange, Yoshie -- George, Benson M -- Humpton, Timothy J -- Brito, Ilana L -- Hiraoka, Yasushi -- Niwa, Osami -- Amon, Angelika -- GM056800/GM/NIGMS NIH HHS/ -- R01 GM056800/GM/NIGMS NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2011 Aug 19;333(6045):1026-30. doi: 10.1126/science.1206412.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉David H. Koch Institute for Integrative Cancer Research and Howard Hughes Medical Institute (HHMI), Massachusetts Institute of Technology, Cambridge, MA 02139, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21852501" target="_blank"〉PubMed〈/a〉
Keywords:
*Aneuploidy
;
Chromosome Segregation
;
Chromosomes, Fungal/genetics
;
*DNA Damage
;
*DNA Repair
;
DNA Replication
;
DNA, Fungal/genetics/metabolism
;
*Genome, Fungal
;
*Genomic Instability
;
Mutagenesis
;
Mutation
;
Neoplasms/genetics
;
Phenotype
;
Rad52 DNA Repair and Recombination Protein/genetics
;
*Recombination, Genetic
;
Saccharomyces cerevisiae/*genetics
;
Saccharomyces cerevisiae Proteins/genetics
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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