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  • Springer  (30)
  • Springer Nature  (10)
  • COPERNICUS GESELLSCHAFT MBH  (5)
  • American Association for the Advancement of Science (AAAS)  (4)
  • 1
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    Adiponectin deficiency exacerbates age-related hearing impairment (2014)
    Springer Nature
    Details
    Publication Date: 2014-04-25
    Description: Adiponectin deficiency exacerbates age-related hearing impairment Cell Death and Disease 5, e1189 (April 2014). doi:10.1038/cddis.2014.140 Authors: T Tanigawa, R Shibata, N Ouchi, K Kondo, M Ishii, N Katahira, T Kambara, Y Inoue, R Takahashi, N Ikeda, S Kihara, H Ueda & T Murohara
    Keywords: adiponectinage-related hearing impairmentstria vascularisapoptosis
    Electronic ISSN: 2041-4889
    Topics: Biology , Medicine
    Published by Springer Nature
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  • 2
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    FTZ-F1, a steroid hormone receptor-like protein implicated in the activation of fushi tarazu (1991)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1991-05-10
    Description: The Drosophila homeobox segmentation gene fushi tarazu (ftz) is expressed in a seven-stripe pattern during early embryogenesis. This characteristic pattern is largely specified by the zebra element located immediately upstream of the ftz transcriptional start site. The FTZ-F1 protein, one of multiple DNA binding factors that interacts with the zebra element, is implicated in the activation of ftz transcription, especially in stripes 1, 2, 3, and 6. An FTZ-F1 complementary DNA has been cloned by recognition site screening of a Drosophila expression library. The identity of the FTZ-F1 complementary DNA clone was confirmed by immunological cross-reaction with antibodies to FTZ-F1 and by sequence analysis of peptides from purified FTZ-F1 protein. The predicted amino acid sequence of FTZ-F1 revealed that the protein is a member of the nuclear hormone receptor superfamily. This finding raises the possibility that a hormonal ligand affects the expression of a homeobox segmentation gene early in embryonic development.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lavorgna, G -- Ueda, H -- Clos, J -- Wu, C -- New York, N.Y. -- Science. 1991 May 10;252(5007):848-51.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Biochemistry, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1709303" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Base Sequence ; Blotting, Northern ; Blotting, Southern ; Blotting, Western ; Chromosome Mapping ; Cloning, Molecular ; Drosophila Proteins ; Drosophila melanogaster ; Fushi Tarazu Transcription Factors ; Gene Expression Regulation ; Genes, Homeobox ; *Homeodomain Proteins ; Insect Hormones/*chemistry ; Molecular Sequence Data ; Open Reading Frames ; RNA/analysis ; Receptors, Steroid/genetics ; Sequence Homology, Nucleic Acid ; Transcription, Genetic ; Zinc Fingers
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Mutational analysis reveals the origin and therapy-driven evolution of recurrent glioma (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-12-18
    Description: Tumor recurrence is a leading cause of cancer mortality. Therapies for recurrent disease may fail, at least in part, because the genomic alterations driving the growth of recurrences are distinct from those in the initial tumor. To explore this hypothesis, we sequenced the exomes of 23 initial low-grade gliomas and recurrent tumors resected from the same patients. In 43% of cases, at least half of the mutations in the initial tumor were undetected at recurrence, including driver mutations in TP53, ATRX, SMARCA4, and BRAF; this suggests that recurrent tumors are often seeded by cells derived from the initial tumor at a very early stage of their evolution. Notably, tumors from 6 of 10 patients treated with the chemotherapeutic drug temozolomide (TMZ) followed an alternative evolutionary path to high-grade glioma. At recurrence, these tumors were hypermutated and harbored driver mutations in the RB (retinoblastoma) and Akt-mTOR (mammalian target of rapamycin) pathways that bore the signature of TMZ-induced mutagenesis.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3998672/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3998672/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Johnson, Brett E -- Mazor, Tali -- Hong, Chibo -- Barnes, Michael -- Aihara, Koki -- McLean, Cory Y -- Fouse, Shaun D -- Yamamoto, Shogo -- Ueda, Hiroki -- Tatsuno, Kenji -- Asthana, Saurabh -- Jalbert, Llewellyn E -- Nelson, Sarah J -- Bollen, Andrew W -- Gustafson, W Clay -- Charron, Elise -- Weiss, William A -- Smirnov, Ivan V -- Song, Jun S -- Olshen, Adam B -- Cha, Soonmee -- Zhao, Yongjun -- Moore, Richard A -- Mungall, Andrew J -- Jones, Steven J M -- Hirst, Martin -- Marra, Marco A -- Saito, Nobuhito -- Aburatani, Hiroyuki -- Mukasa, Akitake -- Berger, Mitchel S -- Chang, Susan M -- Taylor, Barry S -- Costello, Joseph F -- 1T32CA15102201/CA/NCI NIH HHS/ -- K08 NS079485/NS/NINDS NIH HHS/ -- K08NS079485/NS/NINDS NIH HHS/ -- P01CA81403/CA/NCI NIH HHS/ -- P30 CA082103/CA/NCI NIH HHS/ -- P30CA82103/CA/NCI NIH HHS/ -- P50 CA097257/CA/NCI NIH HHS/ -- P50CA097257/CA/NCI NIH HHS/ -- R01 CA163336/CA/NCI NIH HHS/ -- R01 CA169316/CA/NCI NIH HHS/ -- R01CA163336/CA/NCI NIH HHS/ -- R01CA169316-01/CA/NCI NIH HHS/ -- R25NS070680/NS/NINDS NIH HHS/ -- T32 CA128583/CA/NCI NIH HHS/ -- T32GM008568/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2014 Jan 10;343(6167):189-93. doi: 10.1126/science.1239947. Epub 2013 Dec 12.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neurological Surgery, University of California, San Francisco, CA 94158, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24336570" target="_blank"〉PubMed〈/a〉
    Keywords: Antineoplastic Agents, Alkylating/*adverse effects/therapeutic use ; Brain/drug effects/pathology ; Brain Neoplasms/*drug therapy/genetics/*pathology ; DNA Helicases/genetics ; DNA Mutational Analysis ; Dacarbazine/adverse effects/*analogs & derivatives/therapeutic use ; Glioma/*drug therapy/genetics/*pathology ; Humans ; Mutagenesis/drug effects ; Neoplasm Grading ; Neoplasm Recurrence, Local/*chemically induced/drug therapy/*genetics ; Nuclear Proteins/genetics ; Proto-Oncogene Proteins B-raf/genetics ; Proto-Oncogene Proteins c-akt/genetics ; TOR Serine-Threonine Kinases/genetics ; Transcription Factors/genetics ; Tumor Suppressor Protein p53/genetics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Purification and properties of Drosophila heat shock activator protein (1987)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1987-11-27
    Description: Drosophila heat shock activator protein, a rare transacting factor which is induced upon heat shock to bind specifically to the heat shock regulatory sequence in vivo, has been purified from shocked cells to more than 95 percent homogeneity by sequence-specific duplex oligonucleotide affinity chromatography. The purified protein has a relative molecular mass of 110 kilodaltons, binds to the regulatory sequence with great affinity and specificity, and strongly stimulates transcription of the Drosophila hsp70 gene. Studies with this regulatory protein should lead to an understanding of the biochemical pathway underlying the heat shock phenomenon.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wu, C -- Wilson, S -- Walker, B -- Dawid, I -- Paisley, T -- Zimarino, V -- Ueda, H -- New York, N.Y. -- Science. 1987 Nov 27;238(4831):1247-53.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Biochemistry, National Cancer Institute, Bethesda, MD 20892.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3685975" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; Drosophila/*genetics ; *Genes ; *Genes, Regulator ; Heat-Shock Proteins/*genetics ; Kinetics ; Molecular Weight
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    Evaluating the dominant components of warming in Pliocene climate simulations (2014)
    COPERNICUS GESELLSCHAFT MBH
    In:  EPIC3Climate of the Past, COPERNICUS GESELLSCHAFT MBH, 10, pp. 79-90, ISSN: 1814-9324
    Details
    Publication Date: 2018-03-07
    Description: The Pliocene Model Intercomparison Project is the first coordinated climate model comparison for a warmer palaeoclimate with atmospheric CO2 significantly higher than pre-industrial concentrations. The simulations of the mid-Pliocene warm period show global warming of between 1.8 and 3.6 °C above pre-industrial surface air temperatures, with significant polar amplification. Here we perform energy balance calculations on all eight of the coupled ocean–atmosphere simulations within PlioMIP Experiment 2 to evaluate the causes of the increased temperatures and differences between the models. In the tropics simulated warming is dominated by greenhouse gas increases, with cloud albedo feedbacks enhancing the warming in most of the models, but by widely varying amounts. The responses to mid-Pliocene climate forcing in the Northern Hemisphere mid-latitudes are substantially different between the climate models, with the only consistent response being a warming due to increased greenhouse gases. In the high latitudes all the energy balance components become important, but the dominant warming influence comes from the clear sky albedo. This demonstrates the importance of specified ice sheet and high latitude vegetation boundary conditions and simulated sea ice and snow albedo feedbacks. The largest components in the overall uncertainty are associated with cloud albedo feedbacks in the tropics and polar clear sky albedo, particularly in sea ice regions. These simulations show that high latitude albedo feedbacks provide the most significant enhancements to Pliocene greenhouse warming.
    Repository Name: EPIC Alfred Wegener Institut
    Type: Article , notRev
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  • 6
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    Mid-Pliocene East Asian monsoon climate simulated in the PlioMIP (2013)
    COPERNICUS GESELLSCHAFT MBH
    In:  EPIC3Climate of the Past, COPERNICUS GESELLSCHAFT MBH, 9, pp. 2085-2099, ISSN: 1814-9324
    Details
    Publication Date: 2017-06-14
    Description: Based on simulations with 15 climate models in the Pliocene Model Intercomparison Project (PlioMIP), the regional climate of East Asia (focusing on China) during the mid-Pliocene is investigated in this study. Compared to the pre-industrial, the multi-model ensemble mean (MMM) of all models shows the East Asian summer winds (EASWs) largely strengthen in monsoon China, and the East Asian winter winds (EAWWs) strengthen in south monsoon China but slightly weaken in north monsoon China in the mid-Pliocene. The MMM of all models also illustrates a warmer and wetter mid-Pliocene climate in China. The simulated weakened mid-Pliocene EAWWs in north monsoon China and intensified EASWs in monsoon China agree well with geological reconstructions. However, there is a large model–model discrepancy in simulating mid-Pliocene EAWW, which should be further addressed in the future work of PlioMIP.
    Repository Name: EPIC Alfred Wegener Institut
    Type: Article , isiRev
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  • 7
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    Using results from the PlioMIP ensemble to investigate the Greenland Ice Sheet during the mid-Pliocene Warm Period (2015)
    COPERNICUS GESELLSCHAFT MBH
    In:  EPIC3Climate of the Past, COPERNICUS GESELLSCHAFT MBH, 11, pp. 403-424, ISSN: 1814-9324
    Details
    Publication Date: 2016-12-09
    Description: During an interval of the Late Pliocene, referred to here as the mid-Pliocene Warm Period (mPWP; 3.264 to 3.025 million years ago), global mean temperature was similar to that predicted for the end of this century, and atmospheric carbon dioxide concentrations were higher than pre-industrial levels. Sea level was also higher than today, implying a significant reduction in the extent of the ice sheets. Thus, the mPWP provides a natural laboratory in which to investigate the long-term response of the Earth's ice sheets and sea level in a warmer-than-present-day world. At present, our understanding of the Greenland ice sheet during the mPWP is generally based upon predictions using single climate and ice sheet models. Therefore, it is essential that the model dependency of these results is assessed. The Pliocene Model Intercomparison Project (PlioMIP) has brought together nine international modelling groups to simulate the warm climate of the Pliocene. Here we use the climatological fields derived from the results of the 15 PlioMIP climate models to force an offline ice sheet model. We show that mPWP ice sheet reconstructions are highly dependent upon the forcing climatology used, with Greenland reconstructions ranging from an ice-free state to a near-modern ice sheet. An analysis of the surface albedo variability between the climate models over Greenland offers insights into the drivers of inter-model differences. As we demonstrate that the climate model dependency of our results is high, we highlight the necessity of data-based constraints of ice extent in developing our understanding of the mPWP Greenland ice sheet.
    Repository Name: EPIC Alfred Wegener Institut
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  • 8
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    Mid-pliocene Atlantic Meridional Overturning Circulation not unlike modern (2013)
    COPERNICUS GESELLSCHAFT MBH
    In:  EPIC3Climate of the Past, COPERNICUS GESELLSCHAFT MBH, 9, pp. 1495-1504, ISSN: 1814-9324
    Details
    Publication Date: 2019-07-17
    Description: In the Pliocene Model Intercomparison Project (PlioMIP), eight state-of-the-art coupled climate models have simulated the mid-Pliocene warm period (mPWP, 3.264 to 3.025 Ma). Here, we compare the Atlantic Meridional Overturning Circulation (AMOC), northward ocean heat transport and ocean stratification simulated with these models. None of the models participating in PlioMIP simulates a strong mid-Pliocene AMOC as suggested by earlier proxy studies. Rather, there is no consistent increase in AMOC maximum among the PlioMIP models. The only consistent change in AMOC is a shoaling of the overturning cell in the Atlantic, and a reduced influence of North Atlantic DeepWater (NADW) at depth in the basin. Furthermore, the simulated mid-Pliocene Atlantic northward heat transport is similar to the pre-industrial. These simulations demonstrate that the reconstructed high-latitude mid-Pliocene warming can not be explained as a direct response to an intensification of AMOC and concomitant increase in northward ocean heat transport by the Atlantic.
    Repository Name: EPIC Alfred Wegener Institut
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  • 9
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    Evaluating the dominant components of warming in Pliocene climate simulations (2014)
    COPERNICUS GESELLSCHAFT MBH
    In:  EPIC3Climate of the Past, COPERNICUS GESELLSCHAFT MBH, 10, pp. 79-90, ISSN: 1814-9359
    Details
    Publication Date: 2016-12-09
    Description: The Pliocene Model Intercomparison Project (PlioMIP) is the first coordinated climate model comparison for a warmer palaeoclimate with atmospheric CO2 significantly higher than pre-industrial concentrations. The simulations of the mid-Pliocene warm period show global warming of between 1.8 and 3.6 °C above pre-industrial surface air temperatures, with significant polar amplification. Here we perform energy balance calculations on all eight of the coupled ocean–atmosphere simulations within PlioMIP Experiment 2 to evaluate the causes of the increased temperatures and differences between the models. In the tropics simulated warming is dominated by greenhouse gas increases, with the cloud component of planetary albedo enhancing the warming in most of the models, but by widely varying amounts. The responses to mid-Pliocene climate forcing in the Northern Hemisphere midlatitudes are substantially different between the climate models, with the only consistent response being a warming due to increased greenhouse gases. In the high latitudes all the energy balance components become important, but the dominant warming influence comes from the clear sky albedo, only partially offset by the increases in the cooling impact of cloud albedo. This demonstrates the importance of specified ice sheet and high latitude vegetation boundary conditions and simulated sea ice and snow albedo feedbacks. The largest components in the overall uncertainty are associated with clouds in the tropics and polar clear sky albedo, particularly in sea ice regions. These simulations show that albedo feedbacks, particularly those of sea ice and ice sheets, provide the most significant enhancements to high latitude warming in the Pliocene.
    Repository Name: EPIC Alfred Wegener Institut
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  • 10
    Electronic Resource
    Electronic Resource
    Molecular cloning of the fibroin light chain complementary DNA and its use in the study of the expression of the light chain gene in the posterior silk gland ofBombyx mori (1985)
    Springer
    Cellular and molecular life sciences 41 (1985), S. 1167-1171 
    Details
    ISSN: 1420-9071
    Keywords: Silkworm ; Bombyx mori ; silk gland ; mRNA ; complementary DNA ; fibroin light chain ; molecular cloning
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Fibroin light chain (L-chain) mRNA (mol. wt 4.0×105 daltons) was purified from the posterior silk gland of the silkworm,Bombyx mori (J-131 strain). Double-stranded complementary DNA was synthesized and inserted into the PstI site of pBR322 employing the oligo(dC)-oligo(dG) tailing method. Several recombinant plasmids containing the inserts of about 800 base pairs were isolated. Hybridization-translation assay demonstrated that these clones hybridized specifically with the fibroin L-chain mRNA. One of these clones (pLA23) was used as a probe to investigate relative concentrations of the fibroin L-chain gene and mRNA in the posterior silk glands at different stages of late larval development.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01951711
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