Publication Date:
1996-06-21
Description:
Insulin-dependent diabetes mellitus (IDDM) is a multigenic autoimmune disease. An IDDM susceptibility gene was mapped to chromosome 2q34. This gene may act early in diabetogenesis, because "preclinical" individuals also showed linkage. Human leukocyte antigen (HLA)-disparate, but not HLA-identical, sibs showed linkage, which was even stronger in families with affected females. The genes encoding insulin-like growth factor-binding proteins 2 and 5 were mapped to a 4-megabase pair interval near this locus. These results indicate the existence of a gene that acts at an early stage in IDDM development, screening for which may identify a specific subset of at-risk individuals.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Morahan, G -- Huang, D -- Tait, B D -- Colman, P G -- Harrison, L C -- New York, N.Y. -- Science. 1996 Jun 21;272(5269):1811-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia. morahan@wehi.edu.au〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8650584" target="_blank"〉PubMed〈/a〉
Keywords:
Alleles
;
Animals
;
Autoantibodies/analysis
;
Chromosome Mapping
;
Chromosomes, Human, Pair 2/*genetics
;
Diabetes Mellitus, Type 1/*genetics
;
Female
;
Gene Frequency
;
*Genetic Linkage
;
*Genetic Markers
;
Genetic Predisposition to Disease
;
HLA Antigens/genetics
;
Humans
;
Insulin-Like Growth Factor Binding Protein 2/genetics
;
Insulin-Like Growth Factor Binding Protein 5/genetics
;
Islets of Langerhans/immunology
;
Male
;
Mice
;
Mice, Inbred NOD/genetics
;
Microsatellite Repeats
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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