ALBERT — All Library Books, journals and Electronic Records Telegrafenberg

1

Digitale Medien

Meiotic drive and myotonic dystrophy (1995)

Hurst, Gregory D.D. ; Hurst, Laurence D. ; Barrett, John A.

[s.l.] : Nature Publishing Group

Nature genetics 10 (1995), S. 132-133

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ISSN: 1546-1718

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Sir — Myotonic dystrophy (DM) is a trinucleotide disorder and in sub-clinical individuals there is considerable variation in the length of the CTG repeat. Two groups have recently analysed the patterns of segregation of different sized alleles at this locus and both report an excess of the ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/ng0695-132

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2

Digitale Medien

Selfish genes move sideways (1992)

Hurst, Gregory D. D. ; Hurst, Laurence D. ; Majerus, Michael E. N.

[s.l.] : Nature Publishing Group

Nature 356 (1992), S. 659-660

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ISSN: 1476-4687

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik

Notizen: [Auszug] A WIDE variety of ultra-selfish genetic elements dwell within the genomes of certain organisms - elements which, for instance, disrupt meiosis and distort sex allocation, and generally propagate themselves at a cost to the host genome1. Their distribution has traditionally been considered to be ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/356659a0

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3

Digitale Medien

Genomic revolutionaries rise up (1996)

Hurst, Laurence D. ; Hurst, Gregory D. D.

[s.l.] : Nature Publishing Group

Nature 384 (1996), S. 317-318

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ISSN: 1476-4687

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik

Notizen: [Auszug] SELFISH elements are heritable factors that manipulate their host's genetics to their own ends and hence spread in populations despite being deleterious. Well-described examples include meiotic drive genes, such as Segregation Distorter (SD) of Drosophila melanogaster. This acts in males to cause ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/384317a0

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4

Digitale Medien

A MSC-ing link in metastasis? (2007)

Hurst, Douglas R ; Welch, Danny R

[s.l.] : Nature Publishing Group

Nature medicine 13 (2007), S. 1289-1291

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Metastases are derived from distinct subpopulations of cells that exist within a tumor. In a classic example, the melanoma cell subtype B16 can be selected from a primary tumor and enriched for an increased tendency to colonize lung. Tumor cell behavior, however, is often remarkably plastic. The ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm1107-1289

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5

Digitale Medien

Evolution of chromosome organization driven by selection for reduced gene expression noise (2007)

Batada, Nizar N ; Hurst, Laurence D

[s.l.] : Nature Publishing Group

Nature genetics 39 (2007), S. 945-949

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ISSN: 1546-1718

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] The distribution of genes on eukaryotic chromosomes is nonrandom, but the reasons behind this are not well understood. The commonly observed clustering of essential genes is a case in point. Here we model and test a new hypothesis. Essential proteins are unusual in that random fluctuations in ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/ng2071

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6

Digitale Medien

Evidence for co-evolution of gene order and recombination rate (2003)

Pál, Csaba ; Hurst, Laurence D.

[s.l.] : Nature Publishing Group

Nature genetics 33 (2003), S. 392-395

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ISSN: 1546-1718

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] There is increasing evidence in eukaryotic genomes that gene order is not random, even allowing for tandem duplication. Notably, in numerous genomes, genes of similar expression tend to be clustered. Are there other reasons for clustering of functionally similar genes? If genes are linked to enable ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/ng1111

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7

Digitale Medien

Clustering of housekeeping genes provides a unified model of gene order in the human genome (2002)

Lercher, Martin J. ; Urrutia, Araxi O. ; Hurst, Laurence D.

[s.l.] : Nature Publishing Group

Nature genetics 31 (2002), S. 180-183

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ISSN: 1546-1718

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] It is often supposed that, except for tandem duplicates, genes are randomly distributed throughout the human genome. However, recent analyses suggest that when all the genes expressed in a given tissue (notably placenta and skeletal muscle) are examined, these genes do not map to random locations ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/ng887

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8

Digitale Medien

Mutations in a new member of the chromodomain gene family cause CHARGE syndrome (2004)

Vissers, Lisenka E L M ; van Ravenswaaij, Conny M A ; Admiraal, Ronald ; [weitere]

[s.l.] : Nature Publishing Group

Nature genetics 36 (2004), S. 955-957

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ISSN: 1546-1718

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] CHARGE syndrome is a common cause of congenital anomalies affecting several tissues in a nonrandom fashion. We report a 2.3-Mb de novo overlapping microdeletion on chromosome 8q12 identified by array comparative genomic hybridization in two individuals with CHARGE syndrome. Sequence analysis of ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/ng1407

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9

Digitale Medien

Discovery of previously unidentified genomic disorders from the duplication architecture of the human genome (2006)

Sharp, Andrew J ; Hansen, Sierra ; Selzer, Rebecca R ; [weitere]

[s.l.] : Nature Publishing Group

Nature genetics 38 (2006), S. 1038-1042

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ISSN: 1546-1718

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Genomic disorders are characterized by the presence of flanking segmental duplications that predispose these regions to recurrent rearrangement. Based on the duplication architecture of the genome, we investigated 130 regions that we hypothesized as candidates for previously undescribed genomic ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/ng1862

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10

Digitale Medien

Dissecting dispensability (2005)

Hurst, Laurence D ; Pál, Csaba

[s.l.] : Nature Publishing Group

Nature genetics 37 (2005), S. 214-215

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ISSN: 1546-1718

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Four-fifths of yeast's genes are not essential for viability. This preponderance of dispensable genes is observed in eukaryotes and prokaryotes, with only one known exception to date (the intracellular parasite Mycoplasma genitalium). Many examples of apparent dispensability may depend on the ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/ng0305-214

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