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  • American Association for the Advancement of Science (AAAS)  (8)
  • Springer Nature  (7)
  • American Physical Society  (3)
  • American Society of Hematology  (2)
  • 1
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    Structural basis of kainate subtype glutamate receptor desensitization (2016)
    Springer Nature
    In: Nature
    Details
    Publikationsdatum: 2016-09-22
    Beschreibung: Structural basis of kainate subtype glutamate receptor desensitization Nature 537, 7621 (2016). doi:10.1038/nature19352 Authors: Joel R. Meyerson, Sagar Chittori, Alan Merk, Prashant Rao, Tae Hee Han, Mihaela Serpe, Mark L. Mayer & Sriram Subramaniam Glutamate receptors are ligand-gated tetrameric ion channels that mediate synaptic transmission in the central nervous system. They are instrumental in vertebrate cognition and their dysfunction underlies diverse diseases. In both the resting and desensitized states of AMPA and kainate receptor subtypes, the ion channels are closed, whereas the ligand-binding domains, which are physically coupled to the channels, adopt markedly different conformations. Without an atomic model for the desensitized state, it is not possible to address a central problem in receptor gating: how the resting and desensitized receptor states both display closed ion channels, although they have major differences in the quaternary structure of the ligand-binding domain. Here, by determining the structure of the kainate receptor GluK2 subtype in its desensitized state by cryo-electron microscopy (cryo-EM) at 3.8 Å resolution, we show that desensitization is characterized by the establishment of a ring-like structure in the ligand-binding domain layer of the receptor. Formation of this ‘desensitization ring’ is mediated by staggered helix contacts between adjacent subunits, which leads to a pseudo-four-fold symmetric arrangement of the ligand-binding domains, illustrating subtle changes in symmetry that are important for the gating mechanism. Disruption of the desensitization ring is probably the key switch that enables restoration of the receptor to its resting state, thereby completing the gating cycle.
    Print ISSN: 0028-0836
    Digitale ISSN: 1476-4687
    Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von Springer Nature
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  • 2
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    Self-assembled monolayers improve protein distribution on holey carbon cryo-EM supports (2014)
    Springer Nature
    Details
    Publikationsdatum: 2014-11-19
    Beschreibung: Poor partitioning of macromolecules into the holes of holey carbon support grids frequently limits structural determination by single particle cryo-electron microscopy (cryo-EM). Here, we present a method to deposit, on gold-coated carbon grids, a self-assembled monolayer whose surface properties can be controlled by chemical modification. We demonstrate the utility of this approach to drive partitioning of ionotropic glutamate receptors into the holes, thereby enabling 3D structural analysis using cryo-EM methods. Scientific Reports 4 doi: 10.1038/srep07084
    Digitale ISSN: 2045-2322
    Thema: Allgemeine Naturwissenschaft
    Publiziert von Springer Nature
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  • 3
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    Formation of giant planets by fragmentation of protoplanetary disks (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2002-12-03
    Beschreibung: The evolution of gravitationally unstable protoplanetary gaseous disks has been studied with the use of three-dimensional smoothed particle hydrodynamics simulations with unprecedented resolution. We have considered disks with initial masses and temperature profiles consistent with those inferred for the protosolar nebula and for other protoplanetary disks. We show that long-lasting, self-gravitating protoplanets arise after a few disk orbital periods if cooling is efficient enough to maintain the temperature close to 50 K. The resulting bodies have masses and orbital eccentricities similar to those of detected extrasolar planets.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mayer, Lucio -- Quinn, Thomas -- Wadsley, James -- Stadel, Joachim -- New York, N.Y. -- Science. 2002 Nov 29;298(5599):1756-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Astronomy, University of Washington, Seattle, WA 98195, USA. lucio@physik.unizh.ch〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12459581" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Computer Simulation ; *Evolution, Planetary ; Gases ; Gravitation ; Hydrogen ; Jupiter ; *Planets
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 4
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    Rapid formation of supermassive black hole binaries in galaxy mergers with gas (2007)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2007-06-09
    Beschreibung: Supermassive black holes (SMBHs) are a ubiquitous component of the nuclei of galaxies. It is normally assumed that after the merger of two massive galaxies, a SMBH binary will form, shrink because of stellar or gas dynamical processes, and ultimately coalesce by emitting a burst of gravitational waves. However, so far it has not been possible to show how two SMBHs bind during a galaxy merger with gas because of the difficulty of modeling a wide range of spatial scales. Here we report hydrodynamical simulations that track the formation of a SMBH binary down to scales of a few light years after the collision between two spiral galaxies. A massive, turbulent, nuclear gaseous disk arises as a result of the galaxy merger. The black holes form an eccentric binary in the disk in less than 1 million years as a result of the gravitational drag from the gas rather than from the stars.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mayer, L -- Kazantzidis, S -- Madau, P -- Colpi, M -- Quinn, T -- Wadsley, J -- New York, N.Y. -- Science. 2007 Jun 29;316(5833):1874-7. Epub 2007 Jun 7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute for Theoretical Physics, University of Zurich, Winterthurestrasse 190, CH-8057 Zurich, Switzerland. lucio@phys.ethz.ch〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17556550" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 5
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    Ecology. Grass trumps trees with fire (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2011-10-15
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mayer, Audrey L -- Khalyani, Azad Henareh -- New York, N.Y. -- Science. 2011 Oct 14;334(6053):188-9. doi: 10.1126/science.1213908.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉School of Forest Resources and Environmental Science, Michigan Technological University, Houghton, MI 49931, USA. almayer@mtu.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21998379" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Ecosystem ; *Trees ; *Tropical Climate
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 6
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    Ecology. Importing timber, exporting ecological impact (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2005-04-16
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mayer, Audrey L -- Kauppi, Pekka E -- Angelstam, Per K -- Zhang, Yu -- Tikka, Paivi M -- New York, N.Y. -- Science. 2005 Apr 15;308(5720):359-60.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉U.S. Environmental Protection Agency, Office of Research and Development, National Risk Management Research Laboratory; Cincinnati, OH 45268, USA. mayer.audrey@epa.gov〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15831743" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Biodiversity ; China ; *Commerce ; *Conservation of Natural Resources ; *Ecosystem ; Finland ; Internationality ; Russia ; *Trees ; *Wood
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 7
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    Mucus enhances gut homeostasis and oral tolerance by delivering immunoregulatory signals (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2013-09-28
    Beschreibung: A dense mucus layer in the large intestine prevents inflammation by shielding the underlying epithelium from luminal bacteria and food antigens. This mucus barrier is organized around the hyperglycosylated mucin MUC2. Here we show that the small intestine has a porous mucus layer, which permitted the uptake of MUC2 by antigen-sampling dendritic cells (DCs). Glycans associated with MUC2 imprinted DCs with anti-inflammatory properties by assembling a galectin-3-Dectin-1-FcgammaRIIB receptor complex that activated beta-catenin. This transcription factor interfered with DC expression of inflammatory but not tolerogenic cytokines by inhibiting gene transcription through nuclear factor kappaB. MUC2 induced additional conditioning signals in intestinal epithelial cells. Thus, mucus does not merely form a nonspecific physical barrier, but also constrains the immunogenicity of gut antigens by delivering tolerogenic signals.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4005805/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4005805/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shan, Meimei -- Gentile, Maurizio -- Yeiser, John R -- Walland, A Cooper -- Bornstein, Victor U -- Chen, Kang -- He, Bing -- Cassis, Linda -- Bigas, Anna -- Cols, Montserrat -- Comerma, Laura -- Huang, Bihui -- Blander, J Magarian -- Xiong, Huabao -- Mayer, Lloyd -- Berin, Cecilia -- Augenlicht, Leonard H -- Velcich, Anna -- Cerutti, Andrea -- AI073899/AI/NIAID NIH HHS/ -- AI095245/AI/NIAID NIH HHS/ -- AI57653/AI/NIAID NIH HHS/ -- AI61093/AI/NIAID NIH HHS/ -- AI74378/AI/NIAID NIH HHS/ -- AI95613/AI/NIAID NIH HHS/ -- AI96187/AI/NIAID NIH HHS/ -- DK072201/DK/NIDDK NIH HHS/ -- P01 AI061093/AI/NIAID NIH HHS/ -- P01 DK072201/DK/NIDDK NIH HHS/ -- P60 DK020541/DK/NIDDK NIH HHS/ -- R01 AI057653/AI/NIAID NIH HHS/ -- R01 AI093577/AI/NIAID NIH HHS/ -- U01 AI095613/AI/NIAID NIH HHS/ -- U19 AI096187/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 2013 Oct 25;342(6157):447-53. doi: 10.1126/science.1237910. Epub 2013 Sep 26.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Medicine, Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24072822" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Cells, Cultured ; Dendritic Cells/immunology ; Galectin 3/genetics/metabolism ; Glycosylation ; *Homeostasis ; Humans ; Immune Tolerance/genetics/*immunology ; Inflammation/immunology ; Intestinal Mucosa/immunology ; Intestine, Small/*immunology ; Lectins, C-Type/genetics/metabolism ; Mice ; Mice, Inbred C57BL ; Mice, Mutant Strains ; Mouth/*immunology ; Mucin-2/genetics/physiology ; Mucus/*immunology ; NF-kappa B/metabolism ; Receptors, IgG/genetics/metabolism ; Transcription, Genetic ; beta Catenin/metabolism
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 8
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    Excepftonally strong near-bottom flows on the continental rise of nova scotia (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-08-21
    Beschreibung: Recent current velocity measurements across the lower continental rise of Nova Scotia show a deep equatorwardflow with speeds (maximum, 73 centimeters per second) among the highest recorded for the deep sea. Silicate measurements indicate that this flow usually consists of southern-source (Antarctic) bottom water. These measurements confirm the existence of a second and deeper western boundary flow that was earlier inferredfrom geological observations.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Richardson, M J -- Wimbush, M -- Mayer, L -- New York, N.Y. -- Science. 1981 Aug 21;213(4510):887-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17775272" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 9
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    Immunoregulatory lymphokines of T hybridomas from AIDS patients: constitutive and inducible suppressor factors (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1984-07-06
    Beschreibung: Supernatants derived from peripheral blood mononuclear cell cultures of certain patients with the acquired immunodeficiency syndrome (AIDS) or its prodromes have the capacity to block T cell-dependent immune reactivity in vitro. T cells derived from a patient positive for antibody to the lymphadenopathy associated virus ( LAV ), and elaborating high titers of these soluble suppressor factors, were fused to a mutagenized clone of the human T lymphoblastoid cell line KE37 . Molecules capable of profoundly depressing T cell-dependent polyclonal antibody production and DNA synthetic responses, either directly or after incubation with normal adherent cells, were isolated from stable hybrid clones.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Laurence, J -- Mayer, L -- CA 35018-01/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1984 Jul 6;225(4657):66-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6328662" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Acquired Immunodeficiency Syndrome/*immunology ; Animals ; Humans ; Hybridomas/*immunology ; Lymphokines/*immunology ; Mice ; Mice, Inbred BALB C ; Monocytes/immunology ; Retroviridae/immunology ; Retroviridae Infections/immunology ; T-Lymphocytes/*immunology
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 10
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    [Working Life] A scientist on any schedule (2017)
    American Association for the Advancement of Science (AAAS)
    In: Science
    Details
    Publikationsdatum: 2017-01-27
    Beschreibung: Author: Audrey L. Mayer
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Geologie und Paläontologie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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