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  • 1
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    A role for thrombin receptor signaling in endothelial cells during embryonic development (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-09-05
    Description: The coagulation protease thrombin triggers fibrin formation, platelet activation, and other cellular responses at sites of tissue injury. We report a role for PAR1, a protease-activated G protein-coupled receptor for thrombin, in embryonic development. Approximately half of Par1-/- mouse embryos died at midgestation with bleeding from multiple sites. PAR1 is expressed in endothelial cells, and a PAR1 transgene driven by an endothelial-specific promoter prevented death of Par1-/- embryos. Our results suggest that the coagulation cascade and PAR1 modulate endothelial cell function in developing blood vessels and that thrombin's actions on endothelial cells-rather than on platelets, mesenchymal cells, or fibrinogen-contribute to vascular development and hemostasis in the mouse embryo.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Griffin, C T -- Srinivasan, Y -- Zheng, Y W -- Huang, W -- Coughlin, S R -- HL44907/HL/NHLBI NIH HHS/ -- HL65590/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 2001 Aug 31;293(5535):1666-70.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Cardiovascular Research Institute, University of California at San Francisco (UCSF), San Francisco, California 94143.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11533492" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Blood Coagulation ; Blood Coagulation Factors/physiology ; Blood Vessels/*embryology/metabolism ; Calcium/metabolism ; Crosses, Genetic ; *Embryonic and Fetal Development ; Endocardium/embryology/metabolism ; Endothelium, Vascular/cytology/*embryology/metabolism ; Factor V/genetics/physiology ; Female ; Fibrinogen/genetics/physiology ; Fibroblasts/metabolism ; Hemorrhage/embryology ; Hemostasis ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Inbred Strains ; Mice, Transgenic ; *Neovascularization, Physiologic ; Phenotype ; Prothrombin/genetics/physiology ; Receptor, PAR-1 ; Receptors, Thrombin/deficiency/genetics/*physiology ; *Signal Transduction ; Thrombin/physiology ; Thromboplastin/genetics/physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    FOOD SCIENCE. Designing a sustainable diet (2015)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2015-10-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Merrigan, Kathleen -- Griffin, Timothy -- Wilde, Parke -- Robien, Kimberly -- Goldberg, Jeanne -- Dietz, William -- New York, N.Y. -- Science. 2015 Oct 9;350(6257):165-6. doi: 10.1126/science.aab2031. Epub 2015 Oct 1.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Trachtenberg School of Public Policy and Public Administration, the George Washington University, Washington, DC 20052, USA. kmerrigan@gwu.edu. ; Friedman School of Nutrition Science and Policy, Tufts University, Medford, MA 02155, USA. ; Milken Institute School of Public Health, the George Washington University, Washington, DC 20052, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26429883" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Diet/*standards ; Food Assistance ; Food Technology/*standards ; Humans ; *Nutrition Policy ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
    Electronic Resource
    Electronic Resource
    Automatic Langmuir probe plasma diagnostic (1987)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 58 (1987), S. 475-476 
    Details
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: The hardware implementation of a computer-based Langmuir probe technique is described. The technique, which is applicable in a wide range of dc plasma conditions, allows a full range of plasma parameters to be measured efficiently.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1139256
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    Paper (German National Licenses)
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  • 4
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    Polymer-based solar cells having an active area of 1.6 cm2 fabricated via spray coating (2015)
    American Institute of Physics (AIP)
    Details
    Publication Date: 2015-12-24
    Description: We demonstrate the fabrication of polymer solar cells in which both a PEDOT:PSS hole transport and a PCDTBT:PC 71 BM photoactive layer are deposited by spray-casting. Two device geometries are explored, with devices having a pixel area of 165 mm 2 attaining a power conversion efficiency of 3.7%. Surface metrology indicates that the PEDOT:PSS and PCDTBT:PC 71 BM layers have a roughness of 2.57 nm and 1.18 nm over an area of 100 μ m 2 . Light beam induced current mapping reveals fluctuations in current generation efficiency over length-scales of ∼2 mm, with the average photocurrent being 75% of its maximum value.
    Electronic ISSN: 2166-532X
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Published by American Institute of Physics (AIP)
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