Publication Date:
1986-09-19
Description:
Prenatal exposure to alcohol produces many developmental defects of the central nervous system, such as microcephaly, mental retardation, motor dysfunction, and cognitive deficiencies. Therefore, the generation of neurons in the cerebral cortex was examined in the offspring of female rats fed a diet containing ethanol. Prenatal exposure to ethanol delayed and extended the period during which cortical neurons were generated, reduced the number of neurons in the nature cortex with the same time of origin, and altered the distribution of neurons generated on a particular day. Thus, the proliferation and migration of cortical neurons are profoundly affected by in utero exposure to ethanol.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Miller, M W -- AA 06916/AA/NIAAA NIH HHS/ -- New York, N.Y. -- Science. 1986 Sep 19;233(4770):1308-11.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3749878" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Cerebral Cortex/*drug effects/embryology
;
Ethanol/*pharmacology
;
Female
;
Gestational Age
;
Humans
;
Motor Cortex/drug effects/embryology
;
Neurons/*drug effects/embryology
;
Pregnancy
;
Rats
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
Permalink
