Publication Date:
1998-11-20
Description:
Serial passage experiments are a form of experimental evolution that is frequently used in applied sciences; for example, in vaccine development. During these experiments, molecular and phenotypic evolution can be monitored in real time, providing insights into the causes and consequences of parasite evolution. Within-host competition generally drives an increase in a parasite's virulence in a new host, whereas the parasite becomes avirulent to its former host, indicating a trade-off between parasite fitnesses on different hosts. Understanding why parasite virulence seldom escalates similarly in natural populations could help us to manage virulence and deal with emerging diseases.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ebert, D -- New York, N.Y. -- Science. 1998 Nov 20;282(5393):1432-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Universitat Basel, Zoologisches Institut, Rheinsprung 9, 4051 Basel, Switzerland. ebert@ubaclu.unibas.ch〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9822369" target="_blank"〉PubMed〈/a〉
Keywords:
Adaptation, Physiological
;
Animals
;
Bacteria/genetics/growth & development/*pathogenicity
;
*Biological Evolution
;
Fungi/growth & development/pathogenicity
;
Genetic Variation
;
*Host-Parasite Interactions
;
Mutation
;
Parasites/genetics/growth & development/*pathogenicity
;
*Serial Passage
;
Virulence
;
Viruses/genetics/growth & development/*pathogenicity
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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