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  • 1
    Electronic Resource
    Electronic Resource
    Olivine flotation and settling experiments on the join Mg2SiO4-Fe2SiO2 (1982)
    Springer
    Contributions to mineralogy and petrology 80 (1982), S. 319-323 
    Details
    ISSN: 1432-0967
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Notes: Abstract Some unusual density relations between olivine and coexisting liquid in the system fosterite-fayalite are reported. At 1 atmosphere pressure olivine floats on its coexisting liquid for intermediate compositions on this binary because of extreme partitioning of Fe into the melt phase. At 20 kilobars the usual behavior of olivine settling occurs because the partitioning of Fe in the melt is reduced, aided possibly by the dissolution of CO2 in the melt from use of a graphite container. Olivine flotation and settling are rapid in a time period of only a few hours because viscosities are a little greater than that of paraffin oil at room temperature. Some adcumulate textures with good triple junction grain boundaries are developed. General observations of differentiated magmatic systems on a number of scales and experimental data indicate that the mechanisms by which magmas can differentiate vary considerably in the ultramafic to tholeiitic compositional range.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00378004
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  • 2
    Electronic Resource
    Electronic Resource
    Primitive basalts and andesites from the Mt. Shasta region, N. California: products of varying melt fraction and water content (1994)
    Springer
    Contributions to mineralogy and petrology 118 (1994), S. 111-129 
    Details
    ISSN: 1432-0967
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Notes: Abstract Quaternary volcanism in the Mt. Shasta region has produced primitive magmas [Mg/(Mg+Fe*)〉0.7, MgO〉8 wt% and Ni〉150 ppm] ranging in composition from high-alumina basalt to andesite and these record variable extents ofmelting in their mantle source. Trace and major element chemical variations, petrologic evidence and the results of phase equilibrium studies are consistent with variations in H2O content in the mantle source as the primary control on the differences in extent of melting. High-SiO2, high-MgO (SiO2=52% and MgO=11 wt%) basaltic andesites resemble hydrous melts (H2O=3 to 5 wt%) in equilibrium with a depleted harzburgite residue. These magmas represent depletion of the mantle source by 20 to 30 wt% melting. High-SiO2, high-MgO (SiO2=58% and MgO=9 wt%) andesites are produced by higher degrees of melting and contain evidence for higher H2O contents (H2O=6 wt%). High-alumina basalts (SiO2=48.5% and Al2O3=17 wt%) represent nearly anhydrous low degree partial melts (from 6 to 10% depletion) of a mantle source that has been only slightly enriched by a fluid component derived from the subducted slab. The temperatures and pressures of last equilibration with upper mantle are 1200°C and 1300°C for the basaltic andesite and basaltic magmas, respectively. A model is developed that satisfies the petrologic temperature constraints and involves magma generation whereby a heterogeneous distribution of H2O in the mantle results in the production of a spectrum of mantle melts ranging from wet (calc-alkaline) to dry (tholeiitic).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01052863
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  • 3
    Electronic Resource
    Electronic Resource
    ProcessingO-glycan core 1, Galβ1-3GalNAcα-R. Specificities of core 2, UDP-GlcNAc: Galβ1-3GalNAc-R(GlcNAc to GalNAc) β6-N-acetylglucosaminyltransferase and CMP-sialic acid:Galβ1-3GalNAc-R α3-sialyltransferase (1993)
    Springer
    Glycoconjugate journal 10 (1993), S. 381-394 
    Details
    ISSN: 1573-4986
    Keywords: glycosyltransferase ; O-glycan ; β6-N-acetylglucosaminyltransferase ; α3-sialyltransferase ; specificity ; leukemia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract To elucidate control mechanisms ofO-glycan biosynthesis in leukemia and to develop biosynthetic inhibitors we have characterized core 2 UDP-GlcNAc:Galβ1-3GalNAc-R(GlcNAc to GalNAc) β6-N-acetylglucosaminyl-transferase (EC 2.4.1.102; core 2 β6-GlcNAc-T) and CMP-sialic acid: Galβ1-3GalNAc-R α3-sialyltransferase (EC 2.4.99.4; α3-SA-T), two enzymes that are significantly increased in patients with chronic myelogenous leukemia (CML) and acute myeloid leukemia (AML). We observed distinct tissue-specific kinetic differences for the core 2 β6-GlcNAc-T activity; core 2 β6-GlcNAc-T from mucin secreting tissue (named core 2 β6-GlcNAc-T M) is accompanied by activities that synthesize core 4 [GlcNAcβ1-6(GlcNAcβ1-3)GalNAc-R] and blood group I [GlcNAcβ1-6(GlcNAcβ1-3)Galβ-R] branches; core 2 β6-GlcNAc-T in leukemic cells (named core 2 β-GlcNAc-T L) is not accompanied by these two activities and has a more restricted specificity. Core 2 β6-GlcNAc-T M and L both have an absolute requirement for the 4- and 6-hydroxyls ofN-acetylgalactosamine and the 6-hydroxyl of galactose of the Galβ1-3GalNAcα-benzyl substrate but the recognition of other substituents of the sugar rings varies, depending on the tissue. α3-sialytransferase from human placenta and from AML cells also showed distinct specificity differences, although the enzymes from both tissues have an absolute requirement for the 3-hydroxyl of the galactose residue of Galβ1-3GalNAcα-Bn. Galβ1-3(6-deoxy)GalNAcα-Bn and 3-deoxy-Galβ1-3GalNAcα-Bn competitively inhibited core 2 β6-GlcNAc-T and α3-sialyltransferase activities, respectively.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00731043
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  • 4
    Electronic Resource
    Electronic Resource
    Substrate specificity and inhibition of UDP-GlcNAc:GlcNAcβ1-2Manα1-6R β1,6-N-acetylglucosaminyltransferase V using synthetic substrate analogues (1995)
    Springer
    Glycoconjugate journal 12 (1995), S. 371-379 
    Details
    ISSN: 1573-4986
    Keywords: GlcNAc-transferase V ; substrate specificity ; inhibition ; leukaemia ; N-linked glycans
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract UDP-GlcNAc:GlcNAc β1-2Manα1-6R (GlcNAc to Man) β1,6-N-acetylglucosaminyltransferase V (GlcNAc-T V) adds a GlcNAcβ1-6 branch to bi- and triantennaryN-glycans. An increase in this activity has been associated with cellular transformation, metastasis and differentiation. We have used synthetic substrate analogues to study the substrate specificity and inhibition of the partially purified enzyme from hamster kidney and of extracts from hen oviduct membranes and acute myeloid leukaemia leukocytes. All compounds with the minimum structure GlcNAcβ1-2Manα1-6Glc/Manβ-R were good substrates for GlcNAc-T V. The presence of structural elements other than the minimum trisaccharide structure affected GlcNAc-T V activity without being an absolute requirement for activity. Substrates with a biantennary structure were preferred over linear fragments of biantennary structures. Kinetic analysis showed that the 3-hydroxyl of the Manα1-3 residue and the 4-hydroxyl of the Manβ- residue of the Manα1-6(Manα1-3)Manβ-RN-glycan core are not essential for catalysis but influence substrate binding. GlcNAcβ1-2(4,6-di-O-methyl-)Manα1-6Glcβ-pnp was found to be an inhibitor of GlcNAc-T V from hamster kidney, hen oviduct microsomes and acute and chronic myeloid leukaemia leukocytes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00731340
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  • 5
    Electronic Resource
    Electronic Resource
    Deciding what to research (1983)
    Springer
    Research in higher education 19 (1983), S. 499-503 
    Details
    ISSN: 1573-188X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Nature of Science, Research, Systems of Higher Education, Museum Science
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01418449
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  • 6
    Electronic Resource
    Electronic Resource
    Modulation ofin vivo neuronal sprouting by serotonin in the adult CNS of the snail (1996)
    Springer
    Cellular and molecular neurobiology 16 (1996), S. 561-576 
    Details
    ISSN: 1573-6830
    Keywords: buccal ganglia ; neurite outgrowth ; supernumerary fibres ; cyproheptadine ; molluscs
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary 1. Duringin situ recovery from a lesion to the cerebrobuccal connective (CBC) in the snailAchatina fulica, neurons of the buccal ganglia undergo extensive regeneration and sprouting as assessed by axonal dye-fillings of the CBC. 2. These changes are preceded by the distal degeneration of severed fibres from the serotonergic metacerebral giant neuron (MCG), which results in the depletion of serotonin (5-HT) in the ipsilateral buccal ganglion. We have investigated the potential role of this depletion in causing some of the ensuing neuroplastic events. 3. Pharmacological depletion of 5-HT using either 5,7-dihydroxtryptamine or p-chlorophenylalanine in normal, unlesioned animals was found to produce supernumerary neuronal labelling similar to that seen following a lesion. 4. Systemic daily injections of 5-HT were found to partly suppress the sprouting response following the CBC lesion. For example, the contralateral uninjured MCG which is normally induced by the lesion to sprout novel projections into the denervated ganglion, is suppressed from doing so by the 5-HT treatment. 5. These growth inhibiting effects of 5-HT upon the contralateral MCG could be antagonized by the prior administration of the 5-HT receptor blocker cyproheptadine, suggesting a specific receptor mediated action. 6. We suggest that 5-HT may play a role in governing the state of neuronal outgrowthin vivo in the CNS of the adult snail, as has been suggested by early developmental and neuronal cultural studies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02152057
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  • 7
    Electronic Resource
    Electronic Resource
    Physiological and molecular effects of brassinosteroids on Arabidopsis thaliana (1993)
    Springer
    Journal of plant growth regulation 12 (1993), S. 61-66 
    Details
    ISSN: 1435-8107
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Abstract We examined the effects of brassinosteroids on Arabidopsis thaliana (L.) Henyh. ecotype Columbia in order to develop a model system for studying gene regulation by plant steroids. Submicromolar concentrations of two brassinosteroids, brassinolide and 24-epibrassinolide, stimulated elongation of Arabidopsis peduncles and inhibited root elongation, respectively. Furthermore, brassinolide altered the abundance of specific in vitro translatable mRNAs from peduncles and whole plants of Arabidopsis. Root elongation in the auxin-insensitive Arabidopsis mutant axr1 was inhibited by 24-epibrassinolide but not by 2,4-D, indicating an independent mode of action for these growth regulators in this physiological response.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00193234
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  • 8
    Electronic Resource
    Electronic Resource
    Tyrosine hydroxylase-negative, dopaminergic neurons are targets for transmitter-depleting action of haloperidol in the snail brain (1996)
    Springer
    Cellular and molecular neurobiology 16 (1996), S. 451-461 
    Details
    ISSN: 1573-6830
    Keywords: antipsychotic ; neuroleptic ; gastropod ; monoamine ; catecholamine ; serotonin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary 1. The effects of long term administration of micromolar concentrations of the D2 antagonist haloperidol upon monoaminergic neurons in the snailLymnaea stagnalis was investigated. 2. Treatment by bath application with 0.5–2.0 micromolar haloperidol, caused a significant, continuous depletion of dopamine levels in the nervous system as revealed by high performance liquid chromatography. 3. A transient depletion of serotonin was also observed, but DOPA and norepinephrine levels were unaffected. Similar depletion of dopamine was observed after the land snail,Achatina fulica, was injected with haloperidol on each of 4 consecutive days. 4. The depletion of dopamine as revealed with glyoxylate-induced fluorescence inLymnaea appears to be restricted to a subpopulation of catecholaminergic neurons which are immuno-negative for tyrosine hydroxylase, the synthetic enzyme responsible for the conversion of tyrosine to DOPA.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02150226
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  • 9
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    Variations on the vev flip-flop: instantaneous freeze-out and decaying dark matter (2019)
    Springer
    Details
    Publication Date: 2019-05-01
    Print ISSN: 1126-6708
    Electronic ISSN: 1029-8479
    Topics: Physics
    Published by Springer
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  • 10
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    Modulation ofin vivo neuronal sprouting by serotonin in the adult CNS of the snail (1996)
    Springer
    Details
    Publication Date: 1996-09-01
    Print ISSN: 0272-4340
    Electronic ISSN: 1573-6830
    Topics: Biology
    Published by Springer
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