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  • Springer  (27)
  • American Association for the Advancement of Science  (1)
  • American Physical Society  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Stimulation of transcription in HEp-2 cells by UV-inactivated poliovirus type 1 (1973)
    Springer
    Cellular and molecular life sciences 29 (1973), S. 1072-1073 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Zusammenfassung Nach Einwirkung UV-inaktivierter Polioviren wurde eine Zunahme der Bindung von Actinomycin-D, eines unspezifischen “Modellrepressors”, durch HEp-2 Zellen um 15–21% beobachtet. Die Proteinhülle UV-inaktivierter Viren verursacht möglicherweise eine Stimulierung der Genaktivität der Wirtszellen, die normalerweise der Kontrolle des intakten Virusgenoms unterliegt.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01946726
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  • 2
    Electronic Resource
    Electronic Resource
    Some physiological effects of measured air ions (1965)
    Springer
    International journal of biometeorology 9 (1965), S. 127-139 
    Details
    ISSN: 1432-1254
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geography , Physics
    Description / Table of Contents: Zusammenfassung Ein Apparat zur Erzeugung dosierbarer Mengen Luftionen wird beschrieben. Applikationsversuche wurden mit Ratten durchgeführt, von denen nur die Nasenlöcher der ionisierten Luft exponiert wurden. Die wirkliche Ionendosis wurde aus dem gesamten Ionenstrom unddem elektrischen Stromfluss durch das Tier in die Erde berechnet. Die vorlÄufigen Ergebnisse zeigten, dass pos. und neg. Luftionen zur Anregung der Herzschlagfolge und der Atemfrequenz führten. Die dazu erforderliche Dosis war bei einzelnen Ratten verschieden.
    Abstract: Resume On décrit ici un appareil permettant d'émettre des quantités mesurables d'ions. On l'a utilisé sur des rats dont seules les narines étaient exposées à l'air ionisé.La dose véritable d'ions fut calculée en partant du courant d'ions total et du flux électrique passant de l'animal à la terre. Les résultats préliminaires montrent que les ions aussi bien positifs que négatifs accélèrent les pulsations du coeur et la respiration. La dose nécessaire à cela était pourtant différente selon les individus.
    Notes: Abstract An apparatus constructed for the generation and administration of measured air ion dosage is described. Experiments were performed on rats in which only the nostrils were exposed to the ionized air. Measurement of total ion current and of the electrical current to ground through the animal provided knowledge of the actual ion dosage. Initial experiments indicated that both positive and negative air ion treatments tended to stimulate heartbeat and respiratory frequencies. However the ion dosage per rat was subject to individual variability.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02188468
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  • 3
    Electronic Resource
    Electronic Resource
    Some physiological effects of air ion treatment without ion inhalation (1965)
    Springer
    International journal of biometeorology 9 (1965), S. 141-147 
    Details
    ISSN: 1432-1254
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geography , Physics
    Description / Table of Contents: Zusammenfassung In einer vorausgegangenen Arbeit wurde über Experimente berichtet, in denen nur die Nasenlöcher von Ratten ionisierter Luft ausgesetzt waren.Hier wurden die Ergebnisse von Ähnlichen Experimenten zusammengestellt,in denen nur die Umgebung der Nase von Ratten (enthaart) der ionisierten Luft ausgesetzt war und nicht die Atmung. Die Herzfrequenz blieb bei Einwirkung neg. Luftionen unverÄndert,bei Einwirkung pos. Luftionen war sie verlangsamt. Die Atemfrequenz blieb unbeeinflusst, es bestand jedoch die Möglichkeit einer Differenz am Ende der Behandlung mit neg. Ionen.
    Abstract: Resume Dans un mémoire précédent, on a rapporté sur des expériences faites en n'exposant que les narines de rats à de l'air ionisé.On donne ici le résultat d'essais semblables effectués en n'exposant que les alentours (rasés) des narines de rats à de l'air ionisé, mais à l'exclusion de l'air respiré. Les pulsations du coeur restèrent inchangées dans le cas d'ions négatifs, elles furent ralenties par des ions positifs. La respiration est restée la mÊme bien qu'une petite différence soit possible à la fin du traitement par ions négatifs.
    Notes: Abstract A companion paper describes experiments in which only the nostrils of rats were exposed to ionized air. This paper gives results obtained from experiments similar, except that the bridge of the animal's nose was exposed to ions but inhalation of the ionized atmosphere was prevented. The heart rate was unaffected by negative air ion exposure, positive air ions caused depressed heartrate.Respiration rate was generally unaffected by ions although there was a possible final difference under negative air ion treatment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02188469
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  • 4
    Electronic Resource
    Electronic Resource
    Some effects of air ions on the activity of rats (1966)
    Springer
    International journal of biometeorology 10 (1966), S. 39-46 
    Details
    ISSN: 1432-1254
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geography , Physics
    Description / Table of Contents: Zusammenfassung Ein Kanalsystem zum Durchfluss von Luft bekannter Ionenkonzentration wurde eingerichtet. Angeschlossen war eine Kammer mit einem beweglichen dielektrischen Boden, der die Registrierung der Aktivität von Ratten ermöglichte. Neben der motorischen Aktivität wurden 6 andere Verhaltensformen der Tiere registriert.Die niedrigste Ionenkonzentration war am wirksamsten zur Anregung der Aktivität. Neben der Ionenkonzentration in der Kammer wurde der von den Tieren eingeatmete Ionenstrom gemessen; er variierte stark von Tier zu Tier.
    Abstract: Resume On a construit un canal dans lequel il est possible de faire circuler de l'air dont la concentration en ions est contrôlable. On y a adjoint une cellule dont le sol est constitué par un diélectrique flexible permettant de déceler électriquement l'activité de petits animaux.En exposant des rats à des concentrations ioniques variables et de polarité différente, on peut constater des effets prononcés sur le comportement des animaux. En effet, en plus de l'activité motrice, on a enregistré six autres formes de ce comportement. Ce sont les plus faibles concentrations qui produisent le plus d'effets. A part la concentration en ions à l'intérieur de la cellule, on a également mesuré la quantité d'ions absorbés par les bêtes par voie respiratoire. Cette quantité varie fortement d'un individu à l'autre.
    Notes: Abstract A duct system was arranged through which flowed air of controlled ion concentration. In series was a chamber with a flexible dielectric floor which made possible electrical detection of activity.Exposure to various ion concentrations of either polarity produced pronounced effects.In addition to gross motor activity six other behavioural parameters were recorded. The lowest ion concentration were most effective. In addition to presenting a controlled ambient ion concertration the ion current drawn by the animal was measured. This varied markedly from rat to rat.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01636119
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  • 5
    Electronic Resource
    Electronic Resource
    Peak changes in electrocardiograms of rats exposed to air ions (1966)
    Springer
    International journal of biometeorology 10 (1966), S. 101-102 
    Details
    ISSN: 1432-1254
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geography , Physics
    Notes: Abstract Electrocardiograms were obtained from rats exposed to air ions both by inhalation and by non inhalation. Progressive changes were noted in the peak heights of the P, Q, and S waves when ions were inhaled. No such changes were observed when ion exposure was by external surface contact alone.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01636125
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  • 6
    Electronic Resource
    Electronic Resource
    Determination of the pore widths of highly porous materials with NMR microscopy (1997)
    Springer
    Fresenius' journal of analytical chemistry 357 (1997), S. 508-513 
    Details
    ISSN: 1432-1130
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The quantitative characterization of macro-porous materials with regard to pore width and pore width distribution was accomplished for the first time by using 1H-NMR microscopy in combination with suitable methods of digital image analysis. Here we present the newly developed algorithm and discuss the first experimental results. Large-pored glass filter systems filled with silicon oil as intrusion fluid were used as references. Silicates of unknown pore width were analyzed both with the new method and with Hg intrusion. NMR image data were recorded using a 3D spin echo sequence, which gave 128 slice images with a spatial resolution of 14.5 μm × 14.5 μm within each slice, with a slice-thickness of 37 μm or 48 μm. A quantitative evaluation of the 3D NMR data, with regard to pore width and pore width distribution, was done using the appropriate image processing function of the HORUS program. Individual slice evaluation was performed first, followed by an analysis of the binding elements between the slices. Pore widths of the glass filters determined using this analytical algorithm were in accordance with the manufacturer’s values, and silicate pore widths were in good agreement with the values determined by Hg intrusion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002160050203
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  • 7
    Electronic Resource
    Electronic Resource
    A third gene locus for tuberous sclerosis is closely linked to the phenylalanine hydroxylase gene locus (1991)
    Springer
    Human genetics 〈Berlin〉 88 (1991), S. 85-90 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Following the observation of a patient suffering from tuberous sclerosis (TSC) with a de novo reciprocal translocation t(3;12)(p26.3;q23.3), we have undertaken a linkage study in 15 TSC families using polymorphic DNA markers neighbouring the chromosome breakpoints. Significant lod scores have been obtained for markers D12S7 (z max=2.34, θ=0.14) and PAH (phenylalanine hydroxylase) (z max=4.34, θ=0.0). In multipoint linkage analysis, the peak lod score was 4.56 at the PAH gene locus. These data suggest the existence of a third gene locus for TSC (TSC3) on chromosome 12q22-24.1. The regions that have been found to be linked to TSC in different families map to the positions of three enzymes, phenylalanine hydroxylase (12q22-24), tyrosinase (11q14-22), and dopamine-beta-hydroxylase (9q34), all of which are involved in the conversion of phenylalanine to catecholamine neurotransmitters or melanin. Disorders of these biochemical pathways might be involved in the pathogenesis of TSC.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00204934
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  • 8
    Electronic Resource
    Electronic Resource
    Chromosomes and DNA-replication of rat kangaroo cells (PtK2) (1972)
    Springer
    Chromosoma 38 (1972), S. 431-440 
    Details
    ISSN: 1432-0886
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The karyotype, chromosomal measurements, and the time course of DNA replication during the S-phase were determined in metaphase chromosomes of non-synchronized monolayer cultures of PtK2 cells (CCL 56) derived from Potorous tridactylis. The karotype was the same as originally determined for this cell line. Chromosomal measurements differed from data for primary bone marrow cells of this species published by Shaw and Krooth. PtK2 cells and chromosomes showed maximal incorporation of tritiated thymidine (3H-TdR) halfway through the S-phase. Chromosome Y1 showed a second peak of 3H-TdR-incorporation at the end of the S-phase in addition to the peak halfway through S. Comparison of grain densities for chromosomal arms showed late replication of the short arms of chromosomes 1, 3, and X. The time course of incorporation of 3H-TdR was changed when cells were treated for 1 h with fluorodeoxyuridine (FUdR) prior to the 3H-TdR-pulse. FUdR-treated cells showed maximum incorporation of 3H-TdR immediately after the beginning of the S-phase, which was followed by a second peak halfway through the S-phase. This indicated that 3H-TdR-incorporation was partially synchronized by treatment of cells with FUdR. Total radioactivity of FUdR-treated cells had increased by 77% in comparison to cells not treated with FUdR, which indicates that approximately 44% of the TdR-precursors of the latter cells may have originated from cellular precursor pools.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00320161
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  • 9
    Electronic Resource
    Electronic Resource
    Parallel and serial processes in the human oculomotor system: bimodal integration and express saccades (1994)
    Springer
    Biological cybernetics 72 (1994), S. 19-34 
    Details
    ISSN: 1432-0770
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Computer Science , Physics
    Notes: Abstract Saccadic reaction times (SRTs) were analyzed in the context of stochastic models of information processing (e.g., Townsend and Ashby 1983) to reveal the processing architecture(s) underlying integrative interactions between visual and auditory inputs and the mechanisms of express saccades. The results support the following conclusions. Bimodal (visual + auditory) targets are processed in parallel, and facilitate SRT to an extent that exceeds levels attainable by probability summation. This strongly implies neural summation between elements responding to spatially aligned visual and auditory inputs in the human oculomotor system. Second, express saccades are produced within a separable processing stage that is organized in series with that responsible for intersensory integration. A model is developed that implements this combination of parallel and serial processing. The activity in parallel input channels is summed within a sensory stage which is organized in series with a pre-motor and motor stage. The time course of each subprocess is considered a random variable, and different experimental manipulations can selectively influence different stages. Parallels between the model and physiological data are explored.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00206235
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  • 10
    Electronic Resource
    Electronic Resource
    In vivo binding of tritiated actinomycin to cellular chromatin (1973)
    Springer
    Naturwissenschaften 60 (1973), S. 52-53 
    Details
    ISSN: 1432-1904
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00591772
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