Publication Date:
2001-11-03
Description:
The bacterial macrolide rapamycin is an efficacious anticancer agent against solid tumors. In a hypoxic environment, the increase in mass of solid tumors is dependent on the recruitment of mitogens and nutrients. When nutrient concentrations change, particularly those of essential amino acids, the mammalian Target of Rapamycin (mTOR) functions in regulatory pathways that control ribosome biogenesis and cell growth. In bacteria, ribosome biogenesis is independently regulated by amino acids and adenosine triphosphate (ATP). Here we demonstrate that the mTOR pathway is influenced by the intracellular concentration of ATP, independent of the abundance of amino acids, and that mTOR itself is an ATP sensor.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dennis, P B -- Jaeschke, A -- Saitoh, M -- Fowler, B -- Kozma, S C -- Thomas, G -- New York, N.Y. -- Science. 2001 Nov 2;294(5544):1102-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉The Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH-4058, Basel, Switzerland.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11691993" target="_blank"〉PubMed〈/a〉
Keywords:
Adaptor Proteins, Signal Transducing
;
Adenosine Triphosphate/*metabolism
;
Amino Acids/metabolism
;
Androstadienes/pharmacology
;
Carrier Proteins/metabolism
;
Cell Line
;
Deoxyglucose/pharmacology
;
Enzyme Activation
;
Homeostasis
;
Humans
;
Insulin/pharmacology
;
Kinetics
;
Phosphoproteins/metabolism
;
Phosphorylation
;
Protein Kinases/*metabolism
;
RNA, Transfer, Amino Acyl/metabolism
;
Recombinant Fusion Proteins/metabolism
;
Ribosomal Protein S6 Kinases/antagonists & inhibitors/metabolism
;
Ribosomes/metabolism
;
Rotenone/pharmacology
;
Signal Transduction
;
Sirolimus/pharmacology
;
TOR Serine-Threonine Kinases
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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