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1

Electronic Resource

Additive cytotoxicity of adriamycin and a naturally occurring growth inhibitor extracted from bovine aorta (1985)

Haid, Max ; Cohen, Justin ; Mazariegos, George ; [et al.]

Springer

Investigational new drugs 3 (1985), S. 23-29

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ISSN: 1573-0646

Keywords: growth inhibitor ; A-10 ; carcinoma ; mammary ; antineoplastic chemotherapy

Source: Springer Online Journal Archives 1860-2000

Topics: Chemistry and Pharmacology , Medicine

Notes: Abstract A factor of nominal molecular weight 6K–10K Daltons, isolated from bovine aorta, has previously been shown to inhibit neovascularization and tumor growth in vivo and the growth of some tumor cells as well as endothelial cells in culture. This factor, termed A-10, was tested alone and in combination with Adriamycin against TA3Ha mammary adenocarcinoma cells in tissue culture. It was found to have cytotoxicity additive to that of Adriamycin in inhibiting the growth of these cells. In vitro and animal studies show that the sequence of Adriamycin → A-10 is superior to either agent alone in delaying the appearance of palpable tumors after subcutaneous injection of 105 pre-treated tumor cells in the tail of strain A mice. While the growth rate of the primary tumor was not affected by such treatment, survival was prolonged to a greater degree by the this sequence than by either of these agents used alone. A-10 treatment reduced the number of metastases to the adrenal gland but not to lung, liver, or lymph nodes. It did, however, reduce the size of metastases to para-aortic lymph nodes.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00176820

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Gastrointestinal chemosensation: chemosensory cells in the alimentary tract (2012)

Breer, H. ; Eberle, J. ; Frick, C. ; [et al.]

Springer

In: Histochemistry and Cell Biology. 2012; 138(1): 13-24. Published 2012 Apr 24. doi: 10.1007/s00418-012-0954-z.

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Publication Date: 2012-04-24

Print ISSN: 0018-2222

Electronic ISSN: 1432-119X

Topics: Biology , Medicine

Published by Springer

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Gustatory sensory cells express a receptor responsive to protein breakdown products (GPR92) (2013)

Haid, Désirée ; Widmayer, Patricia ; Voigt, Anja ; [et al.]

Springer

In: Histochemistry and Cell Biology. 2013; 140(2): 137-145. Published 2013 Feb 24. doi: 10.1007/s00418-013-1080-2.

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Publication Date: 2013-02-24

Print ISSN: 0018-2222

Electronic ISSN: 1432-119X

Topics: Biology , Medicine

Published by Springer

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Additive cytotoxicity of adriamycin and a naturally occurring growth inhibitor extracted from bovine aorta (1985)

Haid, Max ; Cohen, Justin ; Mazariegos, George ; [et al.]

Springer

In: Investigational New Drugs. 1985; 3(1): Published 1985 Jan 01. doi: 10.1007/bf00176820.

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Publication Date: 1985-01-01

Print ISSN: 0167-6997

Electronic ISSN: 1573-0646

Topics: Chemistry and Pharmacology , Medicine

Published by Springer

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Lipidomic Phenotyping Reveals Extensive Lipid Remodeling during Adipogenesis in Human Adipocytes (2020)

Miehle, Florian ; Möller, Gabriele ; Cecil, Alexander ; [et al.]

Molecular Diversity Preservation International

In: Metabolites. 2020; 10(6): 217. Published 2020 May 26. doi: 10.3390/metabo10060217.

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Publication Date: 2020-05-26

Description: Differentiation of preadipocytes into mature adipocytes is a highly complex cellular process. At lipidome level, the adipogenesis remains poorly characterized. To investigate the lipidomic changes during human adipogenesis, we used the LipidyzerTM assay, which quantified 743 lipid species from 11 classes. The undifferentiated human SGBS cell strain showed a heterogeneous lipid class composition with the most abundant classes, phosphatidylethanolamines (PE), phosphatidylcholines (PC), and sphingomyelins (SM). The differentiation process was accompanied by increased ceramide concentrations. After completion of differentiation around day 4, massive lipid remodeling occurred during maturation, characterized by substantial synthesis of diacylglycerols (DAG), lysophosphatidylethanolamines (LPE), PC, PE, SM, and triacylglycerols (TAG). Lipid species composition became more homogeneous during differentiation to highly concentrated saturated and monounsaturated long-chain fatty acids (LCFA), with the four most abundant being C16:0, C16:1, C18:0, and C18:1. Simultaneously, the amount of polyunsaturated and very long-chain fatty acids (VLCFA) markedly decreased. High negative correlation coefficients between PE and PC species containing VLCFA and TAG species as well as between ceramides and SM imply that PE, PC, and ceramides might have served as additional sources for TAG and SM synthesis, respectively. These results highlight the enormous remodeling at the lipid level over several lipid classes during adipogenesis.

Electronic ISSN: 2218-1989

Topics: Biology , Medicine

Published by Molecular Diversity Preservation International

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Characterization of Bulk Phosphatidylcholine Compositions in Human Plasma Using Side-Chain Resolving Lipidomics (2019)

Quell, Jan D. ; Römisch-Margl, Werner ; Haid, Mark ; [et al.]

Molecular Diversity Preservation International

In: Metabolites. 2019; 9(6): 109. Published 2019 Jun 08. doi: 10.3390/metabo9060109.

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Publication Date: 2019-06-08

Description: Kit-based assays, such as AbsoluteIDQTM p150, are widely used in large cohort studies and provide a standardized method to quantify blood concentrations of phosphatidylcholines (PCs). Many disease-relevant associations of PCs were reported using this method. However, their interpretation is hampered by lack of functionally-relevant information on the detailed fatty acid side-chain compositions as only the total number of carbon atoms and double bonds is identified by the kit. To enable more substantiated interpretations, we characterized these PC sums using the side-chain resolving LipidyzerTM platform, analyzing 223 samples in parallel to the AbsoluteIDQTM. Combining these datasets, we estimated the quantitative composition of PC sums and subsequently tested their replication in an independent cohort. We identified major constituents of 28 PC sums, revealing also various unexpected compositions. As an example, PC 16:0_22:5 accounted for more than 50% of the PC sum with in total 38 carbon atoms and 5 double bonds (PC aa 38:5). For 13 PC sums, we found relatively high abundances of odd-chain fatty acids. In conclusion, our study provides insights in PC compositions in human plasma, facilitating interpretation of existing epidemiological data sets and potentially enabling imputation of PC compositions for future meta-analyses of lipidomics data.

Electronic ISSN: 2218-1989

Topics: Biology , Medicine

Published by Molecular Diversity Preservation International

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Metabolite Shifts Induced by Marathon Race Competition Differ between Athletes Based on Level of Fitness and Performance: A Substudy of the Enzy-MagIC Study (2020)

Schader, Jana F. ; Haid, Mark ; Cecil, Alexander ; [et al.]

Molecular Diversity Preservation International

In: Metabolites. 2020; 10(3): 87. Published 2020 Mar 01. doi: 10.3390/metabo10030087.

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Publication Date: 2020-03-01

Description: This study compared metabolite shifts induced by training for, participation in, and recovery from a marathon race competition among athletes divided into three groups based on fitness (relative maximum oxygen uptake (VO2max)) and performance levels (net running time). Plasma samples from 76 male runners participating in the Munich Marathon were analyzed for metabolite shifts using a targeted metabolomics panel. For the entire cohort of runners, pronounced increases were measured immediately after the race for plasma concentrations of acylcarnitines (AC), the ratio (palmitoylcarnitine + stearoylcarnitine)/free carnitine that is used as a proxy for the activity of the mitochondrial enzyme carnitine palmitoyltransferase, and arginine-related metabolites, with decreases in most amino acids (AA) and phospholipids. Plasma levels of AA and phospholipids were strongly increased 24 and 72 h post-race. Post-race plasma concentrations of AC and arginine-related metabolites were higher in the low compared to top performers, indicating an accumulation of fatty acids and a reliance on protein catabolism to provide energy after the marathon event. This study showed that marathon race competition is associated with an extensive and prolonged perturbation in plasma metabolite concentrations with a strong AC signature that is greater in the slower, less aerobically fit runners. Furthermore, changes in the arginine-related metabolites were observed.

Electronic ISSN: 2218-1989

Topics: Biology , Medicine

Published by Molecular Diversity Preservation International

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Leg Dominance as a Risk Factor for Lower-Limb Injuries in Downhill Skiers—A Pilot Study into Possible Mechanisms (2019)

Promsri, Arunee ; Longo, Alessia ; Haid, Thomas ; [et al.]

Molecular Diversity Preservation International

In: International Journal of Environmental Research and Public Health. 2019; 16(18): 3399. Published 2019 Sep 13. doi: 10.3390/ijerph16183399.

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Publication Date: 2019-09-13

Description: Leg dominance has been reported as one potential risk factor for lower-limb injuries in recreational downhill skiers. The current study proposed and tested two possible mechanisms for a leg dominance effect on skiing injuries—imbalance of the knee muscle strength and bilateral asymmetry in sensorimotor control. We hypothesized that the knee muscle strength (Hypothesis 1; H1) or postural control (Hypothesis 2; H2) would be affected by leg dominance. Fifteen well-experienced recreational downhill skiers (aged 24.3 ± 3.2 years) participated in this study. Isometric knee flexor/extensor muscle strength was tested using a dynamometer. Postural control was explored by using a kinematic principal component analysis (PCA) to determine the coordination structure and control of three-dimensional unipedal balancing movements while wearing ski equipment on firm and soft standing surfaces. Only H2 was supported when balancing on the firm surface, revealing that when shifting body weight over the nondominant leg, skiers significantly changed the coordination structure (p 〈 0.006) and the control (p 〈 0.004) of the lifted-leg movements. Based on the current findings, bilateral asymmetry in sensorimotor control rather than asymmetry in strength seems a more likely mechanism for the previously reported effect of leg dominance on lower-limb injury risk in recreational downhill skiers.

Print ISSN: 1661-7827

Electronic ISSN: 1660-4601

Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine

Published by Molecular Diversity Preservation International

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Katabatic winds and polynya dynamics at Coats Land, Antarctica (2013)

Ebner, Lars ; Heinemann, Günther ; Haid, Verena ; [et al.]

Cambridge University Press

In: Antarctic Science. 2013; 26(3): 309-326. Published 2013 Nov 26. doi: 10.1017/s0954102013000679.

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Publication Date: 2013-11-26

Description: Mesoscale model simulations were conducted for the Weddell Sea region for the autumn and winter periods of 2008 using a high-resolution, limited-area, non-hydrostatic atmospheric model. A sea ice–ocean model was run with enhanced horizontal resolution and high-resolution forcing data of the atmospheric model. Daily passive thermal and microwave satellite data was used to derive the polynya area in the Weddell Sea region. The focus of the study is on the formation of polynyas in the coastal region of Coats Land, which is strongly affected by katabatic flows. The polynya areas deduced from two independent remote sensing methods and data sources show good agreement, while the results of the sea ice simulation show some weaknesses. Linkages between the pressure gradient force composed of a katabatic and a synoptic component, offshore wind regimes and polynya area are identified. It is shown that the downslope surface offshore wind component of Coats Land is the main forcing factor for polynya dynamics, which is mainly steered by the offshore pressure gradient force, where the katabatic force is the dominant term. We find that the synoptic pressure gradient is opposed to the katabatic force during major katabatic wind events.

Print ISSN: 0954-1020

Electronic ISSN: 1365-2079

Topics: Biology , Geography , Geosciences

Published by Cambridge University Press

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Atmospheric forcing of coastal polynyas in the south-western Weddell Sea (2015)

Haid, Verena ; Timmermann, Ralph ; Ebner, Lars ; [et al.]

Cambridge University Press

In: Antarctic Science. 2015; 27(4): 388-402. Published 2015 Jan 29. doi: 10.1017/s0954102014000893.

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Publication Date: 2015-01-29

Description: The development of coastal polynyas, areas of enhanced heat flux and sea ice production strongly depend on atmospheric conditions. In Antarctica, measurements are scarce and models are essential for the investigation of polynyas. A robust quantification of polynya exchange processes in simulations relies on a realistic representation of atmospheric conditions in the forcing dataset. The sensitivity of simulated coastal polynyas in the south-western Weddell Sea to the atmospheric forcing is investigated with the Finite-Element Sea ice-Ocean Model (FESOM) using daily NCEP/NCAR reanalysis data (NCEP), 6 hourly Global Model Europe (GME) data and two different hourly datasets from the high-resolution Consortium for Small-Scale Modelling (COSMO) model. Results are compared for April to August in 2007–09. The two coarse-scale datasets often produce the extremes of the data range, while the finer-scale forcings yield results closer to the median. The GME experiment features the strongest winds and, therefore, the greatest polynya activity, especially over the eastern continental shelf. This results in higher volume and export of High Salinity Shelf Water than in the NCEP and COSMO runs. The largest discrepancies between simulations occur for 2008, probably due to differing representations of the ENSO pattern at high southern latitudes. The results suggest that the large-scale wind field is of primary importance for polynya development.

Print ISSN: 0954-1020

Electronic ISSN: 1365-2079

Topics: Biology , Geography , Geosciences

Published by Cambridge University Press

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