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  • Articles  (24)
  • American Geophysical Union  (9)
  • Nature Publishing Group  (5)
  • Wiley  (5)
  • American Society of Hematology  (3)
  • Wiley-Blackwell  (2)
  • PANGAEA
  • 1965-1969  (24)
Collection
  • Articles  (24)
Year
Journal
  • 1
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 222 (1969), S. 1081-1082 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Fig. 1. Melanosome complexes from a malpighian cell of a Caucasoid. The complexes are surrounded by a membrane and contain small particles besides the stage IV melanosomes (x 50,000). Fig. 2. Melanosome complexes from a malpighian cell of a Mongoloid (Chinese). There is less ground substance ...
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  • 2
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 211 (1966), S. 146-147 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] CHANG et at.1 reported that hexamethylphosphoramide {HMPA), an analogue of tepa, is an effective chemosteri-lant for houseflies. They emphasized that it has a low toxicity to mammals, and also that it has a wide margin of safety for flies between a lethal dose and a dose effectively sterilizing the ...
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  • 3
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 209 (1966), S. 88-89 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] It is generally recognized that the liver is the main site of metabolism of foreign compounds in mammals. Compounds may enter the body through a variety of routes: the gastrointestinal tract, skin and respiratory system being the most important. Absorption by any of these routes involves either ...
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  • 4
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 206 (1965), S. 746-746 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Recently, I have completed a study of the electro-encephalographic (EEG) alpha rhythm recorded while nonsense syllables were being read. The apparatus was so arranged that whenever alpha occurred, a nonsense syllable was projected on to a screen for 0.2 sec. If alpha was not present the syllable ...
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  • 5
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 211 (1966), S. 730-730 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] More recently, use has been made of the magneto-optic effects and, in particular, Green and Thomas3 have developed a simple technique in which hysteresis loops are obtained using the transverse Kerr effect in the infra-red. With a 50 c/s drive field reversing the magnetization, the intensity ...
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  • 6
    Electronic Resource
    Electronic Resource
    New York : Wiley-Blackwell
    Journal of Polymer Science Part A-2: Polymer Physics 7 (1969), S. 1705-1719 
    ISSN: 0449-2978
    Keywords: Physics ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: The temperature dependence of relative modulus observed in filled thermoset, thermoplastic, and polyelectrolyte salt matrices is explained on the basis of induced stresses produced by the differences in the thermal expansion coefficients of the constituent materials. The analysis is based on the assumption that the modulus of the matrix in a filled polymer is less than that of the unfilled polymer. The temperature dependence of relative modulus is expressed as a function of the difference in thermal expansion coefficients, the volume fraction, the relative modulus in the unstressed state, and mechanical properties of the phases. Agreement is good between the analysis and experimental results for three systems: epoxy and glass, polyethylene and wollastonite, and a polyelectrolyte salt with mica and asbestos.
    Additional Material: 7 Ill.
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  • 7
    Electronic Resource
    Electronic Resource
    New York : Wiley-Blackwell
    Journal of Polymer Science Part A: General Papers 3 (1965), S. 2400-2400 
    ISSN: 0449-2951
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
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  • 8
    Publication Date: 1965-01-01
    Description: Two adult patients with sickle cell anemia of blood group A and A2B respectively, received sufficient transfusions of group O blood to maintain nearly normal hemoglobin concentrations for 4 months or longer. Serial samples of the erythrocytes of each recipient were obtained by agglutination with anti-A (and anti-B) serum. The proportion of Hb F in the agglutinated erythrocytes was determined. Early in the transfusion period, a marked rise in the proportion of Hb F was noted. This rise was attributed to prolonged survival of erythrocytes which contained larger proportions of Hb F. In the later part of the transfusion period, the proportion of fetal hemoglobin declined to pre-transfusion levels or below. However, significant amounts of fetal hemoglobin in the erythrocytes of each patient were demonstrated throughout the period of study, and Fe59 incorporation into Hb F in vivo was demonstrated in one patient after 4 months of transfusion therapy. Under the conditions of these studies, synthesis of Hb F continued despite prolonged correction of the anemia. A decline in the proportion of Hb F in the erythrocytes of one patient after 5 months of transfusions suggested that Hb F synthesis may ultimately be depressed by transfusions. It was suggested that the proportion of fetal hemoglobin observed in the erythrocytes might in certain diseases reflect the degree of anemia present many months before.
    Print ISSN: 0006-4971
    Electronic ISSN: 1528-0020
    Topics: Biology , Medicine
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  • 9
    Publication Date: 1968-09-01
    Description: A new unstable hemoglobin variant, hemoglobin Gun Hill, is reported. Two members of a Caucasian family were found to be heterozygous for the abnormal hemoglobin. Evidence of mild chronic hemolysis was found in both individuals. Heinz-Ehrlich bodies were absent from the peripheral blood of the patients with hemoglobin Gun Hill, but Heinz-like inclusions were readily produced in their red cells upon in vitro incubation with the redox dyes brilliant cresyl blue or new methylene blue. Precipitation of hemoglobin occurred when solutions of hemoglobin Gun Hill were exposed to the dyes or were heated to 50 C. Previous studies have shown that there is a deletion of five amino acids in the β chains of hemoglobin Gun Hill. This results in impaired heme binding, and the abnormal molecule lacks half the expected number of heme groups. These structural alterations are probably responsible for the instability of the abnormal hemoglobin. Studies of the relative rates of synthesis of hemoglobins A and Gun Hill, using in vitro and in vivo technics, indicated an increased turnover rate for the variant protein. The evidence also suggested that hemoglobin Gun Hill is synthesized more rapidly than hemoglobin A.
    Print ISSN: 0006-4971
    Electronic ISSN: 1528-0020
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  • 10
    Publication Date: 1969-08-01
    Description: A Jewish family in which Hb L Ferrara (α247 Asp → Gly β2) occurred is reported. Studies of some of the properties of this hemoglobin demonstrated that its oxygen equilibria, number of readily reactive-SH groups, and spectro-photometric tyrosine titration were indistinguishable from Hb A. Nevertheless, Hb LF was more unstable than Hb A at 55 C. The propositus had accelerated blood destruction although six other heterozygotes for Hb LF did not. A second defect in red cell enzymes or red cell lipids of the propositus was not demonstrable with the technics used but the possibility that the simultaneous occurrence of Hb LF and an otherwise "silent" red cell defect may lead to a hemolytic state remains an attractive explanation. The data provided by this family study did not permit a definite conclusion about the relationship of clinically evident hemolysis in the propositus to the presence of the abnormal hemoglobin.
    Print ISSN: 0006-4971
    Electronic ISSN: 1528-0020
    Topics: Biology , Medicine
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