ISSN:
1432-1211
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract Concepts of “antigenic strength” in organ transplantation have been evaluated in relation to orthotopic kidney allografts inH-1 congenic strains of rats. Untreated recipients reject fully allogeneic kidneys possessing singleH-1 differences as acutely as kidneys displaying multiple histocompatibility differences. Heterozygozity for H-1 specificities as well as for H-1 plus non-H-1 specificities (semiallogeneic kidneys) favors long term survival (autoenhancement), especially when the specific immune response genes of the recipient lead to reduced reactivity. In active enhancement, the transplantedH-1 congenic kidneys, devoid of additional weak antigens, retain prolonged functional integrity. Weak non-H-1 antigens substantially influence the successful establishment of specific enhancement in an adverse way, either as additive immunogens or as target sites for the effector arm of the rejection response.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01564065
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