ISSN:
1432-0770
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Computer Science
,
Physics
Notes:
Abstract A model for neuronal encoders is presented. Its mathematical description consists of two coupled first order, non-linear differential equations giving the time course of the membrane potential and of a leak function under conditions of continuous drive. The leak function is given by the ratio of the transmembrane conductance to the effective encoder capacitance and is closely tied to the Hodgkin-Huxley results on the behavior of g K and g Na. Since neuronal impulse encoding does not in general proceed in a space clamped region, the values of membrane potential and “leak” entering the differential equations are those at the trigger zone. The effects of electrotonic spread are then incorporated in the leak function. A particularly simple two parameter form of the model is explicitly written. By changing the value of one of the parameters the properties of the model change from that of exhibiting all features of rapid adaptation to those of tonic repetitive firing. Predictions of the model are discussed, as is the relationship between properties of the model and features of voltage clamp data.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00288789
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