ISSN:
0018-019X
Keywords:
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The synthesis of the antibiotic anisomycin (1) is described. In the key step 3, 4-dimethoxy-thiopyrrolidone (16), prepared from diethyl L-( + )-tartarate (4) was converted to the thioiminoester 18, which upon treatment with trimethylphosphite yielded the benzylidene derivative 19. Cleavage of the ester group of 19 and hydrogenation of the decarboxylation product gave the two isomers 21 and 22. 22 was converted into desacetylanisomycin (3) and anisomycin (1).
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/hlca.19700530409
Permalink