ISSN:
0018-019X
Keywords:
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Vicinal α-hydroperoxy-tetrahydropyranyl ethers annelated to cyclododecane are smoothly converted by homolytic fission in about 75% yield to a mixture of the macrocyclic lactones 3, 4, and 5. Based on this observation, an economically feasible synthesis of Exaltolide1 (〉65% yield) has been developed. The mechanism of this new β-fragmentation reaction is discussed.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/hlca.19710540854
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