Publication Date:
1978-11-03
Description:
Directly active mutagens are formed on exposure of the promutagen benzo[a]pyrene to gaseous pollutants in smog. In simulated atmospheres containing 1 part per million nitrogen dioxide and traces of nitric acid, directly mutagenic nitro derivatives are readily formed from both benzo[a]pyrene and perylene, a non-mutagen in the Ames reversion assay. Possible formation of direct mutagens by such reactions on sample collection filters, in exhaust effluents, and in the atmosphere should be recognized.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pitts, J N Jr -- Van Cauwenberghe, K A -- Grosjean, D -- Schmid, J P -- Fitz, D R -- Belser, W L -- Knudson, G P -- Hynds, P M -- New York, N.Y. -- Science. 1978 Nov 3;202(4367):515-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/705341" target="_blank"〉PubMed〈/a〉
Keywords:
*Air Pollutants
;
Benzopyrenes
;
*Mutagens
;
Nitrogen Dioxide
;
Oxidation-Reduction
;
Perylene
;
Photochemistry
;
*Polycyclic Compounds
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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