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  • 1
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    Cocaine plasma concentration: relation to physiological and subjective effects in humans (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-10-13
    Description: Volunteer subjects with previous histories of cocaine use were administered cocaine hydrochloride intravenously or intranasally. There was a positive relationship between peak plasma concentration, physiological and subjective responses, and dose administered. The rate of cocaine disappearance after intravenous administration paralleled the drop in physiological and subjective drug effects. After intranasal administration, blood levels remained elevated for a considerably longer period.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Javaid, J I -- Fischman, M W -- Schuster, C R -- Dekirmenjian, H -- Davis, J M -- New York, N.Y. -- Science. 1978 Oct 13;202(4364):227-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/694530" target="_blank"〉PubMed〈/a〉
    Keywords: Administration, Intranasal ; Cocaine/administration & dosage/*blood/*pharmacology ; Dose-Response Relationship, Drug ; Euphoria/*drug effects ; Heart Rate/drug effects ; Humans ; Injections, Intravenous ; Kinetics ; Metabolic Clearance Rate
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Schizophrenic symptoms improve with apomorphine (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-05-05
    Description: Eighteen chronic schizophrenic patients received subcutaneous doses of apomorphine, a dopamine receptor agonist, and of placebo in separate trials. A significant improvement in psychotic symptoms occurred after apomorphine compared to placebo. The results are interpreted as a consequence of presynaptic dopamine receptor activation by apomorphine with a subsequent decrease in dopamine-mediated neural transmission.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tamminga, C A -- Schaffer, M H -- Smith, R C -- Davis, J M -- New York, N.Y. -- Science. 1978 May 5;200(4341):567-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/347574" target="_blank"〉PubMed〈/a〉
    Keywords: Apomorphine/pharmacology/*therapeutic use ; Chronic Disease ; Clinical Trials as Topic ; Dose-Response Relationship, Drug ; Double-Blind Method ; Female ; Humans ; Male ; Nerve Endings/drug effects ; Receptors, Dopamine/drug effects ; Schizophrenia/*drug therapy
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Lithium transport across red cell membrane: a cell membrane abnormality in manic-depressive illness (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-08-31
    Description: In the families of manic-depressive patients, relatives with a history of affective disorders had a significantly higher ratio of mean red cell lithium to plasma lithium in vitro than relatives with no such history. A genetically controlled abnormality in lithium-sodium transport, the mechanism that determines the lithium ratio, may play a role in the etiology of some forms of affective disorders.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dorus, E -- Pandey, G N -- Shaughnessy, R -- Gaviria, M -- Val, E -- Ericksen, S -- Davis, J M -- New York, N.Y. -- Science. 1979 Aug 31;205(4409):932-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/472716" target="_blank"〉PubMed〈/a〉
    Keywords: Biological Transport ; Bipolar Disorder/blood/genetics/*metabolism ; Cations, Monovalent/metabolism ; Erythrocyte Membrane/*metabolism ; Erythrocytes/*metabolism ; Humans ; Lithium/*blood ; Pedigree ; Sodium/blood
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
    Electronic Resource
    Electronic Resource
    THE USE OF ANIMAL MODELS FOR STUDIES ON ASBESTOS BIOEFFECTS (1979)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 330 (1979), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1979.tb18785.x
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  • 5
    Electronic Resource
    Electronic Resource
    A new algorithm for digraph isomorphism (1977)
    Springer
    BIT 17 (1977), S. 16-30 
    Details
    ISSN: 1572-9125
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Abstract A new and efficient procedure for testing a pair of digraphs for isomorphism is developed. It is based on conducting a depth-first search on one of the digraphs followed by a systematic matching of edges using backtracking with very effective pruning. It is proved that for digraphs (ofn vertices) the expected time complexity of this procedure isO(n logn ). This theoretical result is verified empirically on more than 300 large random digraphs. This procedure is shown to be more efficient than any of the existing general isomorphism procedures.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01932396
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  • 6
    Electronic Resource
    Electronic Resource
    The gross energy balance of solar active regions (1977)
    Springer
    Solar physics 55 (1977), S. 387-392 
    Details
    ISSN: 1573-093X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract According to Parker's earlier articles in this journal the photospheric temperature is lower in sunspots than elsewhere because of increased outflow of mechanical energy, rather than inhibited inflow from the convective zone. In this case the atmosphere above the spot group receives an excess supply of energy that must equal the deficiency in radiative power output of the spot group compared with the normal photosphere. The extra power supplied to the atmosphere was then assumed to be lost by radiation. On 26 November 1973 the active region McMath 12628 was studied with sufficient precision to test for this equality. It is shown that the atmosphere did not radiate and almost certainly did not receive, more than a very small part of the ‘missing flux’ of the spot group. This result is an important constraint on the plausible theories of sunspot formation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00152581
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  • 7
    Electronic Resource
    Electronic Resource
    Solar wind stream structure during the early phase of solar cycles 20 and 21 (1978)
    Springer
    Solar physics 60 (1978), S. 207-210 
    Details
    ISSN: 1573-093X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract We compare average values of solar wind stream amplitude, maximum velocity and half-width for periods shortly after the minima preceding Solar Cycles 20 and 21. The differences between average amplitudes and half-widths are not significant, but higher maximum velocities were observed for streams during the early part of Cycle 21. Comparing with previously published results, we conclude that, except for the large streams seen late in the solar cycle, the variation of these stream parameters is nearly as large from cycle to cycle as it is within a solar cycle.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00152344
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  • 8
    Electronic Resource
    Electronic Resource
    The relationship between solar activity and coronal hole evolution (1978)
    Springer
    Solar physics 60 (1978), S. 143-153 
    Details
    ISSN: 1573-093X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract We examine the relationship between coronal hole evolution and solar active regions during the Skylab period. We find a tendency for holes to grow or remain stable when the activity nearby, seen as calcium plages and bright regions in X-rays, is predominantly large, long-lived regions. This is consistent with results of previous studies, using somewhat different methods. We also find that there is a significantly higher number of small, short-lived active regions, as indicated by X-ray bright points, in the vicinity of decaying holes than there is near other holes. We interpret this to mean that holes disappear at least in part because they become filled with many small scale, magnetically closed, X-ray emitting features. This interpretation, together with the previously reported observation that the number of X-ray bright points was much larger near solar minimum than it was during the Skylab period, provides a possible explanation for the disappearance of the large, near-equatorial coronal holes at the time of solar minimum.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00152339
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  • 9
    Electronic Resource
    Electronic Resource
    The interpretation of simultaneous soft X-ray spectroscopic and imaging observations of an active region (1975)
    Springer
    Solar physics 45 (1975), S. 393-410 
    Details
    ISSN: 1573-093X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Simultaneous soft X-ray spectroscopic and broad band imaging observations of an active region have been analyzed together to determine the parameters which describe the coronal plasma. From the spectroscopic data, models of temperature-emission measure-elemental abundance have been constructed which provide acceptable statistical fits. By folding these possible models through the imaging analysis, models which are not self-consistent can be rejected. In this way, only the oxygen, neon and iron abundances of Pottasch (1967), combined with either an isothermal or exponential temperature-emission measure model are consistent with both sets of data. Contour maps of electron temperature and density for the active region have been constructed from the imaging data. The implications of the analysis to the determination of coronal abundances and to future satellite experiments are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00158458
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  • 10
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    The gross energy balance of solar active regions (1977)
    Springer
    Details
    Publication Date: 1977-12-01
    Print ISSN: 0038-0938
    Electronic ISSN: 1573-093X
    Topics: Physics
    Published by Springer
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