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  • 1
    Electronic Resource
    Electronic Resource
    Hybrid resistance of bone marrow stroma to precursor cells (1977)
    Springer
    Bulletin of experimental biology and medicine 83 (1977), S. 390-392 
    Details
    ISSN: 1573-8221
    Keywords: heterotopic transplantation ; bone marrow ; stromal precursor cells ; hybrid resistance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The focus of hematopoiesis arising after transplantation of a fragment of bone marrow from a C57BL mouse beneath the capsule of the kidney of a syngeneic mouse contains more hematopoietic cells than if transplanted into a semisyngeneic (CBA x C57BL)F1 recipient. Experiments with repopulation of the graft, when depopulated by irradiation, by injected hematopoietic cells of the same genotype as the graft (C57BL) showed that these differences are due to the smaller size of the hemotopoietic microenvironment in the focus formed in the hybrid than in the syngeneic system. Hybrid resistance is thus manifested not only against hematopoietic cells, but also against stromal precursors transferring the hematopoietic microenvironment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00799373
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  • 2
    Electronic Resource
    Electronic Resource
    Self-support of migrating hematopoietic stem cells (1979)
    Springer
    Bulletin of experimental biology and medicine 87 (1979), S. 611-614 
    Details
    ISSN: 1573-8221
    Keywords: hematopoietic stem cells ; migration ; self-support
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract A study of the number of stem cells in splenic colonies and of marked chromosomes in the progeny of the stem cells that recirculating colony-forming units from peripheral blood or from a focus of ectopic hematopoiesis have reduced self-support potential compared with settling (from bone marrow) colony-forming units. The powers of differentiation of the two subpopulations of stem cells were identical.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00801400
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  • 3
    Electronic Resource
    Electronic Resource
    Effect of the thymus on precursor cells of the hematopoietic stroma (1979)
    Springer
    Bulletin of experimental biology and medicine 87 (1979), S. 617-619 
    Details
    ISSN: 1573-8221
    Keywords: hematopoietic microenvironment ; precursor cells ; heterotopic focus of hematopoiesis ; thymectomy ; stroma of hematopoietic organ
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract It was shown by transplantation of a fragment of bone marrow beneath the capsule of the kidney that thymectomy reduces the number of cells constructing the hematopoietic microenvironment. Transplantation of the thymus abolishes the effect of thymectomy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00801402
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  • 4
    Electronic Resource
    Electronic Resource
    Two populations of bone marrow cells creating an ectopic hematopoietic focus (1977)
    Springer
    Bulletin of experimental biology and medicine 83 (1977), S. 218-221 
    Details
    ISSN: 1573-8221
    Keywords: bone marrow ; heterotopic transplantation ; osteogenic precursor cells ; radiosensitivity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract A fragment of bone marrow transplanted beneath the capsule of the kidney creates a focus of ectopic hematopoiesis the size of which, measured according to the number of hematopoietic cells, is proportional to the size of the implant. In irradiated recipients the focus was 1.5–2.5 times larger than in intact recipients. Cells creating a focus of heterotopic hematopoiesis in intact and irradiated recipients differed in their radiosensitivity: their D0 values were about 160 and 350 rad, respectively. In this connection it is postulated that two populations of precursor cells participate in the creation of the focus. Their possible relations with predetermined and inducible osteogenic precursor cells are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00799428
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  • 5
    Electronic Resource
    Electronic Resource
    Role of the bone marrow stroma in the hybrid resistance phenomenon (1979)
    Springer
    Bulletin of experimental biology and medicine 87 (1979), S. 343-346 
    Details
    ISSN: 1573-8221
    Keywords: bone marrow ; heterotopic transplantation ; hybrid resistance ; chromosomal markers
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract An irradiated fragment of bone marrow was implanted beneath the capsule of the kidney. Karyologic analysis showed that all hematopoietic cells in the newly formed focus were of recipient origin. Meanwhile, resistance to the bone marrow graft was of donor type. Cells of hematopoietic origin capable of migration, including lymphocytes and macrophages, play no part in the phenomenon of hybrid resistance.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00804418
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  • 6
    Electronic Resource
    Electronic Resource
    Effect of abolition of hybrid resistance on survival of radiation chimeras (1977)
    Springer
    Bulletin of experimental biology and medicine 83 (1977), S. 47-50 
    Details
    ISSN: 1573-8221
    Keywords: hybrid resistance ; radiation chimeras
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The effect of abolition of hybrid resistance by injection of lymphocytes on survival of lethally irradiated mice protected by transplantation of semiallogeneic bone marrow was studied. Injection of C57BL lymphocytes into (C57BL×CBA)F1 recipients 1 day before irradiation and transplantation of bone marrow of the same genotype (C57BL) increased the survival rate of the chimeras compared with untreated recipients, whereas the same treatment, given 7 days before irradiation, reduced the survival rate of the chimeras. Injection of lymphocytes of the parental line had a negligible action on the radioresistance both of the hematopoietic stem cells (as shown by the endocolonization test) and on the body as a whole (as shown by the 30-day survival test) of the F1 hybrid; it is accordingly concluded that differences in the effectiveness of the splenocytes when injected at different times before irradiation cannot be explained by changes in radioresistance.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00802803
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  • 7
    Electronic Resource
    Electronic Resource
    Origin of hematopoietic cells in syngeneic and semisyngeneic foci of heterotopic hematopoiesis (1977)
    Springer
    Bulletin of experimental biology and medicine 83 (1977), S. 693-695 
    Details
    ISSN: 1573-8221
    Keywords: bone marrow ; heterotopic transplantation ; hematopoietic stem cells ; chromosomal labeling
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Foci of heterotopic hematopoiesis were obtained by transplanting bone marrow of C57BL/6 or (CBAxC57BL)F1 mice beneath the kidney capsule of (CBA/T6T6xC57BL)F1 mice carrying a chromosomal translocation. Cytogenetic analysis of hematopoietic cells from these foci 20–120 days after transplantation showed that only the recipient's hematopoietic cells proliferate in 40% of the grafts, whereas the rest are mosaic and contain on average less than 20% of the donor's cells in both syngeneic and semisyngeneic systems. These characteristics remain stable for at least 4 months. It is concluded that the heterotopic focus is populated in one stage by a very small number (fewer than 10) hematopoietic stem cells. The stability of the clones is evidence that in the dynamic equilibrium of hematopoiesis the exchange of cells between different parts of the hematopoietic system is extremely small or is absent altogether.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00800752
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