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  • 1
    Electronic Resource
    Electronic Resource
    Isolation, purification, and reconstitution of a proline carrier protein from Mycobacterium phlei (1979)
    s.l. : American Chemical Society
    Biochemistry 18 (1979), S. 2232-2239 
    Details
    ISSN: 1520-4995
    Source: ACS Legacy Archives
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/bi00578a015
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  • 2
    Electronic Resource
    Electronic Resource
    Pyrolysis of 1-phenyl-1,3-butadienes. New synthesis of 1,2-dihydronaphthalenes (1975)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 97 (1975), S. 901-902 
    Details
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ja00837a041
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  • 3
    Electronic Resource
    Electronic Resource
    Hedgehogs use toad venom in their own defence (1977)
    [s.l.] : Nature Publishing Group
    Nature 268 (1977), S. 627-628 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The survival value of spines is enhanced by the hedgehog rolling into a ball or 'boxing' when contacted or approached by a predator. Boxing consists of erecting the spines over the head and lunging into the approaching predator. Hedgehogs also display a curious behaviour pattern known as ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/268627a0
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  • 4
    Electronic Resource
    Electronic Resource
    Estimation of accessibility of DNA in chromatin from fluorescence measurements of electronic excitation energy transfer (1975)
    [s.l.] : Nature Publishing Group
    Nature 253 (1975), S. 470-471 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The dyes quinacrine, acridine orange and 33258 Hoechst were chosen as energy donors. All three bind tightly to DNA and chromatin, exhibiting a fluorescence emission spectrum that extensively overlaps the absorption spectrum of the energy acceptor used, ethidium bromide. Following excitation of the ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/253470a0
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  • 5
    Electronic Resource
    Electronic Resource
    Hemolymph regulation to hyposaline and hypersaline conditions inGammarus oceanicus (Crustacea: Amphipoda) (1978)
    Springer
    Cellular and molecular life sciences 34 (1978), S. 1297-1298 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Specimens ofGammarus oceanicus were exposed to sea water at salinities of 3%. and 55%. for various periods of time up to 24 h.G. oceanicus can regulate in hyposaline sea water and reached a new steady state after 4 h exposure to 3%. sea water. Its ability to regulated in hypersaline conditions is limited and no animals survived longer than 6–8 h in 55%. sea water. These results are discussed with respect to salinity conditions in the intertidal zone.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01981429
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  • 6
    Electronic Resource
    Electronic Resource
    Decreased drug binding in serum from patients with chronic hepatic disease (1976)
    Springer
    European journal of clinical pharmacology 9 (1976), S. 429-432 
    Details
    ISSN: 1432-1041
    Keywords: Drug-protein binding ; hepatic disease ; salicylate ; sulphadiazine ; phenylbutazone
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The binding of 3 drugs to serum proteins of patients with chronic hepatic disease has been studied by an ultrafiltration technique, and compared to that of normal subjects. The binding of phenylbutazone was reduced in all patients, salicylate in patients with inactive liver disease and sulphadiazine in patients whose disease was active. Analysis of binding data showed a real reduction in the capacity of albumin to bind the drugs in the majority of patients. Addition of bilirubin to normal plasma caused a reduction in sulphadiazine binding, but had no effect on the binding of salicylate or phenylbutazone. The possible causes of this reduction in binding are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00606560
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  • 7
    Electronic Resource
    Electronic Resource
    Discriminable textures with identical buffon needle statistics (1978)
    Springer
    Biological cybernetics 31 (1978), S. 231-234 
    Details
    ISSN: 1432-0770
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Computer Science , Physics
    Notes: Abstract A method is presented for generating pairs of textures for which the statistics of intersection with any collinear set of points placed at random on either texture are the same. The constraint that such “Buffon needle statistics” be identical is stronger than identity of second-order statistics. Nonetheless, many such texture pairs are effortlessly distinguishable. An example is given of such a texture pair, whose components are composed of either congruent ellipses or circles of various radii. The discriminability of such texture pairs implies that adequate models for human texture preception must contain local nonlinearities which receive input from non-collinear points.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00337094
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  • 8
    Electronic Resource
    Electronic Resource
    Protein binding of salicylate in cutaneous hepatic porphyria (1978)
    Springer
    European journal of clinical pharmacology 13 (1978), S. 309-313 
    Details
    ISSN: 1432-1041
    Keywords: Protein binding ; cutaneous hepatic porphyria ; ultrafiltration ; salicylates
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary (1) Plasma protein binding of salicylate was studied in 14 patients with cutaneous hepatic porphyria (CHP) and 11 normal subjects using ultrafiltration with centrifugation (membrane cones) and continuous ultrafiltration. (2) Albumin and haemoglobin levels were significantly reduced in patients with CHP, and salicylate binding by ultrafiltration/centrifugation was 65% compared with 84% in normal subjects. (3) Plasma porphyrin levels were raised, but did not correlate with salicylate binding, and protoporphyrin or uroporphyrin added to plasma did not alter the amount of drug bound. (4) Palmitate added to plasma reduced salicylate binding by 9 to 20% but a crossover of patient and normal plasma proteins and ultrafiltrates confirmed that no other ultrafiltrable metabolites present in patient plasma appeared to cause decreased binding. (5) Scatchard plots obtained by continuous ultrafiltration for normal and patient plasma showed a reduction in the number of primary and secondary binding sites and an increase in the intrinsic association constants for both these sites. (6) It was concluded that the decreased salicylate binding in CHP was due to a reduced albumin concentration and altered salicylate albumin interaction.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00716368
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  • 9
    Electronic Resource
    Electronic Resource
    The effects of chronic alcohol ingestion and alcoholic liver disease on binding of drugs to serum proteins (1978)
    Springer
    European journal of clinical pharmacology 13 (1978), S. 435-438 
    Details
    ISSN: 1432-1041
    Keywords: Drug-protein binding ; liver disease ; alcohol ; bilirubin ; albumin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The binding of salicylate, sulphadiazine and phenylbutazone in whole serum of patients with alcohol-induced liver disease has been compared to that of chronic alcoholics with no evidence of liver disease, and normal healthy subjects. Binding of all three drugs was normal in the chronic alcoholic group, but decreased in patients with alcoholic liver disease. In subjects with alcoholic hepatitis, this decrease appeared to be correlated with variations in serum bilirubin and albumin levels. These observations may be of clinical relevance to the distribution of drugs in alcoholic patients with accompanying hepatic disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00566322
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  • 10
    Electronic Resource
    Electronic Resource
    The ultrastructure of the sinus gland of Gammarus oceanicus (Crustacea: Amphipoda) (1977)
    Springer
    Cell & tissue research 182 (1977), S. 557-564 
    Details
    ISSN: 1432-0878
    Keywords: Sinus gland ; Gammarus ; Neurosecretion ; Ultrastructure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The sinus gland of Gammarus oceanicus, like that of other crustaceans, is composed of three elements: neurosecretory axons, glial cells and stromal sheath. Five neurosecretory axon types are identified on the basis of granule diameter, shape, and electron density, and axon matrix density. Exocytosis appears to be the major release mechanism of neurosecretory material. The preterminal regions of neurosecretory axons contain axoplasmic reticulum and neurotubules. Their arrangement in the axon and relationship with one another suggest a transport function. Multilamellar bodies are found in the terminal regions of neurosecretory axons. They arise from mitochondria and may be involved in granulolysis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00219838
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