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  • 1
    Electronic Resource
    Electronic Resource
    Field desorption and electron impact mass spectra of ionic dyes (1977)
    s.l. : American Chemical Society
    Analytical chemistry 49 (1977), S. 922-926 
    Details
    ISSN: 1520-6882
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ac50015a014
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  • 2
    Electronic Resource
    Electronic Resource
    Aequorin luminescence during activation of single isolated smooth muscle cells (1979)
    [s.l.] : Nature Publishing Group
    Nature 280 (1979), S. 506-508 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] All experiments were performed on single smooth muscle cells isolated from the stomach muscle of the toad, Bufo marinus, by an enzymatic digestion technique that involved the use of trypsin and collagenase. Isolated cells obtained by this technique exhibit physiological, pharmacological, metabolic ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/280506a0
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  • 3
    Electronic Resource
    Electronic Resource
    Limits to the expansion of Earth, Moon, Mars and Mercury and to changes in the gravitational constant (1978)
    [s.l.] : Nature Publishing Group
    Nature 271 (1978), S. 316-321 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] New estimates of the palaeoradius of the Earth for the past 400 Myr from palaeomagnetic data limit possible expansion to less than 0.8%, sufficient to exclude any current theory of Earth expansion. The lunar surface has remained static for 4,000 Myr with possible expansion limited to 0.06%, the ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/271316a0
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  • 4
    Electronic Resource
    Electronic Resource
    Rare earth element mobility associated with uranium mineralisation (1979)
    [s.l.] : Nature Publishing Group
    Nature 282 (1979), S. 247-250 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Extreme rare earth element mobility has been discovered, associated with uranium mineralisation in metasedimentary rocks of the Lower Proterozoic Pine Creek Geosyncline, Australia. The rare earth element patterns and other geochemical evidence point to movement of the rare earth elements and ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/282247a0
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  • 5
    Electronic Resource
    Electronic Resource
    The B-chromosome system of Hypochoeris maculata (1978)
    Springer
    Chromosoma 67 (1978), S. 123-143 
    Details
    ISSN: 1432-0886
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The meiotic process in PMCs of Hypochoeris maculata is progressively disrupted in the presence of two or more B-chromosomes. Bivalent formation and chiasma conditions are unaffected by up to 3Bs although some univalence occurs with higher numbers. Spindle behaviour, however, is inefficient at both first and second division in the presence of two or more Bs. At metaphase I, regular equatorial alignment breaks down and A-bivalents sometimes show amphitelic or monosyntelic orientation. Anaphase I is characterised by irregular segregation, equatorial laggards and centric division products. The proportion of normal anaphase segregations declines by 20% for every B more than one. A-chromosome laggards, but not Bs, can induce nuclear restitution at telophase I. Following centric division at anaphase II poleward movement can fail leading to further nuclear restitution. Telophase II nuclei thus can be approximately haploid, diploid or tetraploid with aneuploid variation around the haploid and diploid levels. The frequency of numerical mutants in the offspring indicates that EMC meiosis is much less susceptible to the presence of Bs than PMC meiosis: only 4- and 5Bt plants have an enhanced frequency of numerically-aberrant offspring. The deleterious effects of Bs on meiotic efficiency will contribute to setting an upper limit on B-numbers in natural populations of this species.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00293170
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  • 6
    Electronic Resource
    Electronic Resource
    Bioavailability of tolamolol (1976)
    Springer
    European journal of clinical pharmacology 9 (1976), S. 315-317 
    Details
    ISSN: 1432-1041
    Keywords: Tolamolol ; bioavailability ; maximum exercise tachycardia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Bioavailability of capsule and tablet formulations of tolamolol were compared by measuring plasma concentration of tolamolol and reduction in maximum exercise heart rate over a period of twelve hours in eight healthy subjects in a two-way cross-over study. Tolamol was absorbed more rapidly from capsules than from tablets; this did not result in any significant difference in the reduction in maximum exercise heart rate between the two formulations. There was no significant difference between area under curve of reduction in exercise tachycardia and area under curve of plasma concentration of tolamolol for the two formulations. Reduction in maximum exercise heart rate was related to logarithm of plasma concentration of tolamolol between two and twelve hours after both formulations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00561666
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  • 7
    Electronic Resource
    Electronic Resource
    The rare earth element geochemistry of granite, gneiss, and migmatite from the Western Metamorphic Belt of South-eastern Australia (1977)
    Springer
    Contributions to mineralogy and petrology 62 (1977), S. 249-263 
    Details
    ISSN: 1432-0967
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Notes: Abstract Four muscovite-biotite granites from the Western Metamorphic Belt of South-eastern Australia have rare earth element patterns characterized by: (i) light rare earth element enrichment; (ii) slight Eu depletion; (iii) varying degrees of heavy rare earth element depletion. The rare earth element and major element chemistry of three of these muscovite-biotite granites (the Koetong, Lockharts and Yabba Granites) can be approximated very closely by a model involving 20% partial melting of an ultrametamorphosed pelitic sediment and contamination of this minimum melt by the residual material left after melting, in the ratio 60% melt: 40% residue. Granitoids can be very largely solid material at the time of emplacement. The other muscovite-biotite granite studied (the Hawksview Granite) has major and trace element characteristics which distinguish if from the other three granitoids and these differences are attributed to variations in source material at the site of melt generation. The rare earth element and major element chemistry of a garnet-cordierite gneiss from the Western Metamorphic Belt can be modelled assuming 5% partial melting of a pelitic metamorphic rock and contamination of the minimum melt by the residue in the ratio 30% melt: 70% residue. Separated granitic and biotitic portions of a migmatite from the Western Metamorphic Belt have rare earth element characteristics which are inconsistent with a simple partial-melting model, but it is suggested that re-equilibration following, or during, separation of the vein material could obscure the process by which the vein of the migmatite developed. It is however certain that the vein developed in situ from a pelitic meta-sediment leaving the biotite rich selvage, without the introduction of material from an external source. Leucogranites which crop out to the east of the Western Metamorphic Belt are high level intrusions of highly fractionated granitic melt. Their Sr isotopic characteristics and features of their major and trace element chemistry suggest that they derive from an igneous source and are not directly related to the granites and gneisses to the west.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00371013
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  • 8
    Electronic Resource
    Electronic Resource
    Spatial variations in the geochemistry of quaternary lavas across the Sunda arc in Java and Bali (1979)
    Springer
    Contributions to mineralogy and petrology 70 (1979), S. 341-356 
    Details
    ISSN: 1432-0967
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Notes: Abstract Since Mesozoic time, Java and Bali have formed part of an evolving system of island arcs comprising the Sunda arc of Indonesia. The present tectonic setting is relatively simple with subduction occurring at the Java Trench to the south. A north-dipping Benioff seismic zone delineates an underthrust lithospheric slab to depths of approximately 600 km beneath the Java Sea. Quaternary lavas of the ‘normal island arc association’ range from tholeiites to high-K calc-alkaline lavas over Benioff zone depths from 120–250 km, respectively. More abundant calc-alkaline lavas lie between these extremes. High-K alkaline lavas are found over Benioff zone depths in excess of 300 km. Both within and between these groups of rocks there are consistent spatial variations in the observed geochemistry. For approximately 200 rocks, incompatible elements such as K, Rb, Cs, Sr, Ba, light REE, U and Th show an increase in abundance of almost an order of magnitude with increasing depth to the seismic zone. Abundances of compatible elements show little consistent variation and trace elements such as Ni, Co, Cr, and Sc are characteristically depleted except in some of the alkaline lavas. Major element abundances in rocks of the normal island arc association show little variation, except for K and P, which both increase in abundance across the arc and Al, which shows a relative decrease. The major and trace element data are inconsistent with the derivation of the analyzed rocks by partial melting of the crustal component of the subducted lithosphere. On the other hand, low Ni abundances (∼20 ppm) in the basalts suggest that most of the lavas are fractionated and few if any represent primary mantle-derived melts. The spatial variations in the geochemistry of erupted lavas across Java and Bali are best explained by a combination of two processes: melting of a geochemically zoned mantle source and smaller degrees of partial melting of that material at progressively greater depths. Primary tholeiitic magmas could be formed by 20–25% melting at depths of 30–40 km, primary high-K calc-alkaline magmas by 5–15% melting at 40–60 km depth, and primary alkaline magmas by 5% melting at depths of 80–90 km. The geochemical zoning in the mantle, which is also manifested by increasing 87Sr/86Sr ratios in lavas across the arc, is interpreted to result from the addition of a small melt fraction derived from the crustal component of the subducted lithosphere.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00375361
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  • 9
    Electronic Resource
    Electronic Resource
    Pharmacological studies with slow-release formulations of oxprenolol in man (1976)
    Springer
    European journal of clinical pharmacology 10 (1976), S. 189-195 
    Details
    ISSN: 1432-1041
    Keywords: Slow-release ; oxprenolol ; plasma concentration ; isoprenaline ; maximum exercise
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary 1.) Circulatory effects of standard commercial and two slow-release preparations of oxprenolol, each containing 80 mg were compared with placebo in a double-blind randomized cross-over study in six normal subjects. 2.) After both slow-release preparations, the concentration of oxprenolol in blood was significantly less at one hour but significantly greater at 4, 8 and 12 hours than after the standard preparation. Variability of blood oxprenolol concentration between individuals was similar after all three formulations. 3.) Blood oxprenolol concentration was linearly related to the suppression of isoprenaline tachycardia and logarithmically related to the reduction in maximum exercise heart rate. 4.) The reduced maximum, but more sustained, blood oxprenolol concentration after the slow release preparations had no significant effect on the reduction of exercise tachycardia at one hour but significantly extended the duration of its activity compared with the commercial preparation. 5.) These results indicate that the pharmacological activity of beta-adrenoceptor antagonists with a relatively short duration of action may be usefully extended by slow-release formulation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00558328
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  • 10
    Electronic Resource
    Electronic Resource
    Geochemistry of eocene calc-alkaline volcanic rocks from the Kastamonu area, Northern Turkey (1976)
    Springer
    Contributions to mineralogy and petrology 58 (1976), S. 63-81 
    Details
    ISSN: 1432-0967
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Notes: Abstract Analytical data for Sr, Rb, Cs, Ba, Pb, rare earth elements, Y, Th, U, Zr, Hf, Sn, Nb, Mo, Ni, Co, V, Cr, Sc, Cu and major elements are reported for eocene volcanic rocks cropping out in the Kastamonu area, Pontic chain of Northern Turkey. SiO2% versus K2O% relationship shows that the analyzed samples belong to two major groups: the basaltic andesitic and the andesitic ones. High-K basaltic andesites and low-K andesites occur too. Although emplaced on continental type basement (the North Anatolian Crystalline Swell), the Pontic eocene volcanics show elemental abundances closely comparable with typical island arc calc-alkaline suites, e.g. low SiO2% range, low to moderate K2O% and large cations (Cs, Rb, Sr, Ba, Pb) contents and REE patterns with fractionated light and almost flat heavy REE patterns. ΣREE and highly charged cations (Th, U, Hf, Sn, Zr) are slightly higher than typical calc-alkaline values. Ferromagnesian elements show variable values. Within the basaltic andesite group the increase of K%, large cations, ΣREE, La/Yb ratio and high valency cations and the decrease of ferromagnesian element abundances with increasing SiO2% content indicate that the rock types making up this group developed by crystalliquid fractionation of olivine and clinopyroxene from a basic parent magma. Trace element concentration suggest that the andesite group was not derived by crystal-liquid fractionation processes from the basaltic andesites, but could represent a distinct group of rocks derived from a different parent magma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00384745
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