ISSN:
1432-1432
Keywords:
Oligoadenylates
;
Phosphorimidazolides
;
Template-directed polycondensation
;
Isomer ratios
;
Prebiotic
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
Notes:
Summary We have studied a variety of condensation reactions involving poly (U) as template and isomeric adenosine dinucleotides as substrates. We find that [3′–5′]-linked dinucleotides such as A3pA and pA3pA are better acceptors than the corresponding [2′–5′]-linked compounds, while ImpA2pA is a better donor than ImpA3pA. The reaction between A2pA and ImpA3pA, for example, yields only 4% of product while the reaction of A3pA with ImpA2pA yields 86% of product. The more efficient condensation reactions of dimers are about as efficient as the self-condensation of ImpA. They yield a few percent of material in which five or more substrate molecules are linked together. The percentage of the natural [3′–5′]-linkage in the product varies greatly, from as little as 1% to as much as 45%.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01732341
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