Publication Date:
1978-01-13
Description:
Tricyclic antidepressants vary in their capacity to cause psychomotor activation, to relieve agitated depressive states, and to cause sedation and hypotension. We have quantified relative potencies of tricyclic antidepressants in competing for the binding of 3H-labeled WB-4101 to alpha-noradrenergic receptor sites in rat brain membranes. Affinities of tricyclic drugs for alpha-noradrenergic receptor sites in the brain correlate well with the capacity of these agents to relieve psychomotor agitation and to induce sedation and hypotension; these affinities also correlate inversely with tendencies to elicit psychomotor activation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉U'Prichard, D C -- Greenberg, D A -- Sheehan, P P -- Snyder, S H -- New York, N.Y. -- Science. 1978 Jan 13;199(4325):197-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/202024" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Antidepressive Agents, Tricyclic/*metabolism/therapeutic use
;
Binding, Competitive
;
Brain/*metabolism
;
Humans
;
Hypotension/chemically induced
;
Psychomotor Agitation/*drug therapy
;
Rats
;
Receptors, Adrenergic/*metabolism
;
Receptors, Adrenergic, alpha/*metabolism
;
Structure-Activity Relationship
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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