Publication Date:
1978-05-19
Description:
Cultures of rheumatoid synovial cells that have been enzymatically dissociated and are adherent to a culture vessel are morphologically heterogeneous. When these cells are cultured on a collagenous substrate for 2 to 6 days at 37 degrees C in serum-free medium, they produce collagenase. A monospecific antibody to human collagenase has localized the enzyme extracellularly around cytoplasmic extensions of dendritic cells and intracellularly within a few macrophage-like and fibroblast-like cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Woolley, D E -- Harris, E D Jr -- Mainardi, C L -- Brinckerhoff, C E -- New York, N.Y. -- Science. 1978 May 19;200(4343):773-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/205952" target="_blank"〉PubMed〈/a〉
Keywords:
Arthritis, Rheumatoid/*enzymology
;
Cells, Cultured
;
Fibroblasts/enzymology
;
Humans
;
Microbial Collagenase/antagonists & inhibitors/*metabolism
;
Synovial Fluid/cytology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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