ISSN:
1573-4927
Keywords:
radioimmunoassay
;
hemoglobin F variants
;
hemoglobinopathies
;
γ chain loci
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Chemistry and Pharmacology
Notes:
Abstract A variant of fetal hemoglobin (Hb F-Malta-I) has been detected and quantitated in adult blood with a sensitive radioimmunoassay employing monospecific anti-sera. The concentration of Hb F-Malta-I was 0.002–0.05%, with an average value of 0.011%. The ratio of Hb F-Malta-I/Hb F in adults was about 4.8%, compared to a ratio of about 27% in the newborn. Since the F-Malta-I variant is a product of a mutated Gγ locus, which is one of the nonallelic structural genes directing the γ chain synthesis, its presence in blood of adults shows that the synthesis of this gene is not completely suppressed after birth, as was previously suggested.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00483988
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