ISSN:
0025-116X
Keywords:
Chemistry
;
Polymer and Materials Science
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
,
Physics
Notes:
Solutions of sodium dextran sulfate and chitosan were co-reacted under various experimental conditions to form a water-insoluble hydrous precipitate. The mole ratios of N/S in the polyelectrolyte complexes were estimated to be 0,79 to 2,54 depending on pH as well as on the mixing ratio of the complexing components. IR spectroscopic studies, blood test, elementary analyses, color reactions with toluidine blue, and the studies on solubility revealed that two polyelectrolyte complexes, different in molecular structure, were formed: series A and B (Tab. 1), where the latter emerged at lower pH condition. It seems that the number of binding sites between —NH3+ and —OSO-3 in B series is smaller than that in A series, considering their nitrogen content or the formation of OSO3H groups in B series. Furthermore, the polyelectrolyte complexes of A series rather suppressed the coagulation of blood, whereas those of B series enhanced it. The mechanism is still not completely elucidated. Nonetheless, the experimental results appear to open an important reservoir of anti-thrombogenetic materials whose properties may be tailored.
Additional Material:
2 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/macp.1977.021781012
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