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  • Artikel  (296)
  • Cell & Developmental Biology  (141)
  • Engineering General  (100)
  • Male
  • 1975-1979  (296)
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  • Artikel  (296)
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  • 1
    Digitale Medien
    Digitale Medien
    Concurrent development of resistance to 6-azauridine and adenosine in a mouse cell line This work was aided by grants from the U.S. Public Health Service (GM 18153 and CA 12504) and the National Foundation-March of Dimes, R.S.K. and O.J.M. are Career Scientists of the Health Research Council of the City of New York. (1975)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 86 (1975), S. 191-200 
    Details
    ISSN: 0021-9541
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Biologie , Medizin
    Notizen: A variant of the hypoxanthine-guanine phosphoribosyltransferase deficient, and adenine phosphoribosyltransferase deficient mouse A9 cell line has been obtained by selecting cells which are resistant to 6-azauridine. These cells are not only resistant to 6-azauridine (5 × 10-4 M), but also to adenosine (10-3 M). Resistance persists indefinitely even in the absence of both compounds. The resistant cells are killed by 5-fluorouridine (10-6 M), indicating that the part of the salvage pathway for pyrimidine ribonucleotide biosynthesis which is relevant to the action of 6-azauridine is intact. The heritable change producing concurrent resistance to 6-azauridine and adenosine probably involves the de novo pyrimidine biosynthetic pathway.
    Zusätzliches Material: 5 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/jcp.1040860202
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  • 2
    Digitale Medien
    Digitale Medien
    Selective lethal effect of thymidine on human and mouse tumor cellsSupported by The Stehlin Foundation for Cancer Research. (1977)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 92 (1977), S. 401-405 
    Details
    ISSN: 0021-9541
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Biologie , Medizin
    Notizen: Human cell lines derived from a melanoma and a colon carcinoma, and cultures of human melanocytes and intestinal epithelial cells, as well as a mouse mesenchymal non-neoplastic cell line and a malignant subline of the same have been quantitatively studied in tissue culture for their sensitivity to thymidine. All three tumor lines produced solid tumors when injected into nude thymus-deficient mice. No tumors were obtained by injecting cells of the human normal long-term cultures or of the non-neoplastic mouse line.The tumor-producing lines showed a greater sensitivity to the lethal effects of high concentrations of thymidine than their non-tumor-producing counterparts. Less than 23% of the tumor cells survived 72 hours in the presence of 1 mg/ml of thymidine, in contrast to 60% or more of the non-tumor cells.Colony formation was much more inhibited by thymidine and the differential between normal and tumor cells was even more pronounced. Tumor cells which also were treated for 72 hours with 1 mg/ml of thymidine and then plated in fresh medium formed very few colonies. If the plating efficiency of the untreated controls is considered as 100%, 4.3% or less of the treated tumor cells formed colonies, in contrast to 33% or more of the non-tumor cells.
    Zusätzliches Material: 3 Tab.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/jcp.1040920308
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  • 3
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    Microwave radiation and chlordiazepoxide: synergistic effects on fixed-interval behavior (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1979-03-30
    Beschreibung: In the presence of low-intensity pulsed microwave radiation, at an average power density of 1 milliwatt per square centimeter, the response-rate-increasing effects of chlordiazepoxide were potentiated in rats. The behavioral effects of a drug can be modified by brief exposure to a low-level microwave field even when the radiation level alone has no apparent effects on the behavior.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Thomas, J R -- Burch, L S -- Yeandle, S S -- New York, N.Y. -- Science. 1979 Mar 30;203(4387):1357-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/424759" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Behavior, Animal/drug effects/*radiation effects ; Chlordiazepoxide/*pharmacology ; Dose-Response Relationship, Drug ; Dose-Response Relationship, Radiation ; Male ; *Microwaves ; Rats
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 4
    facet.materialart.
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    Microwaves: effect on thermoregulatory behavior in rats (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1979-12-07
    Beschreibung: Rats, with their fur clipped, pressed a lever to turn on an infrared lamp while in a cold chamber. When they were exposed to continuous-wave microwaves at 2450 megahertz for 15-minute periods, the rate at which they turned on the infrared lamp decreased as a function of the microwave power density, which ranged between 5 and 20 milliwatts per square centimeter. This result indicates that behaviorally significant levels of heating may occur at an exposure duration and intensities that do not produce measurable changes in many other behavioral measures or in colonic temperature. Further study of how microwaves affect thermoregulatory behavior may help us understand such phenomena as the reported "nonthermal" behavioral effects of microwaves.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stern, S -- Margolin, L -- Weiss, B -- Lu, S T -- Michaelson, S M -- New York, N.Y. -- Science. 1979 Dec 7;206(4423):1198-201.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/505008" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Behavior, Animal/*radiation effects ; Body Temperature Regulation/*radiation effects ; Male ; *Microwaves ; Rats
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 5
    Digitale Medien
    Digitale Medien
    Displacement oscillation in plane quadratic isoparametric elements in orthotropic situations (1979)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 14 (1979), S. 913-920 
    Details
    ISSN: 0029-5981
    Schlagwort(e): Engineering ; Engineering General
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Mathematik , Technik allgemein
    Notizen: Long thin test specimens of orthotropic material are modelledby quadratic isoparametric finite elements in plane strain. Displacement oscillations occur down the long free edge of themodel with both reduced (2 × 2) and full (3 × 3) integration, themagnitude of the oscillations being affected by element aspectratio and the elastic constants of the material. The rate ofdiffusion of stress as predicted by the classical shear-lag theory, being dependent on the material constants, is reflectedin the displacement oscillations near the load in 3 × 3integration. In 2 × 2 integration, however, this effect is swampedby the build-up of oscillations away from the restraints in alowenergy deformation mode which becomes dominant as the elementaspect ration is increased. These latter voscillations arepredicted by the illconditioning of the structural stiffnessmatrix measured by a solution diagonal decay factor.
    Zusätzliches Material: 7 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/nme.1620140610
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  • 6
    Digitale Medien
    Digitale Medien
    A numerical method for analysis of bounded metalworking processes (1979)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 14 (1979), S. 1165-1182 
    Details
    ISSN: 0029-5981
    Schlagwort(e): Engineering ; Engineering General
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Mathematik , Technik allgemein
    Notizen: This paper describes a numerical procedure for the solution of metalworking problems of a strain-hardening material. The overall metalworking process is split up into a number of stages and the governing equations for a typical stage are set up in terms of incremental displacements. The incremental deformation occurring in each successive stage is found by an interative numerical procedure based on the concept of piecewise linearization. The ‘composite’ solution yields the distribution of stress and strain in the work material at various stages of the process. Finally, application of the method to finite axisymmetric compression is described.
    Zusätzliches Material: 11 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/nme.1620140805
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  • 7
    Digitale Medien
    Digitale Medien
    The finite element method in problems of nonlinear optics (1979)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 14 (1979), S. 1581-1596 
    Details
    ISSN: 0029-5981
    Schlagwort(e): Engineering ; Engineering General
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Mathematik , Technik allgemein
    Notizen: The Possibility of the application of the finite element method to some problems of nonlinear optics is investigated in this paper. The self-action of a light beam in a nonlinear medium is considered. The general approach to the cretion of conservative computation schemes is presented, based on varitional principles. Definite schemes, which are applicable for the problem of thermal self-action, are described in detail both in the case of cylindrical and or rectangular co-ordinates. The accuracy and convergence of the models are analysed. The results of computation of the self-action problems in motionless and moving media are presented.
    Zusätzliches Material: 10 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/nme.1620141102
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  • 8
    Digitale Medien
    Digitale Medien
    Dynamic response of strip footings on elastic halfspace (1979)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 14 (1979), S. 1597-1612 
    Details
    ISSN: 0029-5981
    Schlagwort(e): Engineering ; Engineering General
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Mathematik , Technik allgemein
    Notizen: Dynamic response of strip footings resting on a soil medium, idealized as an elastic halfspace, is obtained using the finite element discretization technique with constant strain rectangular elements consisting of 4CST elements. Boundary stresses have been computed using a combination of Rayleigh wave absorbing boundaries (RAB) and standard vicous boundaries (SVB). The influences of contact pressure distributions at the footing - soil interface, mass and frequency ratios on the dynamic response of a strip footing are studied. Effects of embedment, static surcharge, nonhomogeneity and nonlinear constitutive relations are shown. Results are compared with the existing solution and are presented graphically.
    Zusätzliches Material: 11 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/nme.1620141103
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  • 9
    Digitale Medien
    Digitale Medien
    Numerical solution of Fredholm integral equations with a logarithmic singularity (1976)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 10 (1976), S. 1202-1207 
    Details
    ISSN: 0029-5981
    Schlagwort(e): Engineering ; Engineering General
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Mathematik , Technik allgemein
    Notizen: Generalized quadrature is used for the numerical solution of two Fredholm integral equations which occur in electrostatics and aerodynamics.
    Zusätzliches Material: 3 Tab.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/nme.1620100522
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  • 10
    Digitale Medien
    Digitale Medien
    Node Reordering algorithms for water network analysis (1978)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 12 (1978), S. 1241-1259 
    Details
    ISSN: 0029-5981
    Schlagwort(e): Engineering ; Engineering General
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Mathematik , Technik allgemein
    Notizen: The node Admittance matrices for Water Networks are normally sparse and symmetrical. Advantage may be taken of these properties to reduce the amount of computational time and memory required to solve them. Two node reordering algorithms and an economic system of storing input data are described. The node reordering algorithms minimize the number of fill-ins which would occur in the solution of the node admittance matrix. Only non-zero elements are stored and operated on. Subroutines for the node reordering algorithms and storge of input data, written in FORTRAN IV are included.
    Zusätzliches Material: 10 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/nme.1620120804
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