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A search for patterns in the nucleotide sequence of the MS2 genome (1979)

Erickson, John W. ; Altman, Gary G.

Springer

Journal of mathematical biology 7 (1979), S. 219-230

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ISSN: 1432-1416

Keywords: Bacteriophages ; Nucleotide sequence ; Spatial Markov chains

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Mathematics

Notes: Summary The nucleotide sequence of the RNA of the bacteriophage MS2 was examined by computer for internal patterns. We used a technique which analyzes a nucleotide sequence as a Markov chain. This led us to discover patterns within the translated and untranslated regions of the RNA in addition to those patterns formed by the codons. One of the more surprising results of this analysis was the discovery that the non-coding sequences in the genome are as highly ordered, although in a different sense, as the genes themselves. Also of interest was the discovery that the codon frequency distributions for the three genes are similar.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00275725

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