Publication Date:
1978-09-22
Description:
Perifusion experiments have shown that there is a discharge of inorganic phosphate into the medium when insulin secretion from isolated islets is stimulated by glucose. Histochemical and microprobe examination of resting pancreatic islets in the electron microscope shows a specific accumulation of inorganic phosphate adjacent to the plasmalemma and nucleolus of the B (beta) cells. This phossphate is lost from the cells during secretory stimulation of islets with high concentrations of glucose.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Freinkel, N -- Pedley, K C -- Wooding, P -- Dawson, R M -- New York, N.Y. -- Science. 1978 Sep 22;201(4361):1124-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/356269" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Bicarbonates/pharmacology
;
Electron Probe Microanalysis
;
Glucose/*pharmacology
;
In Vitro Techniques
;
Islets of Langerhans/cytology/drug effects/*metabolism
;
Microscopy, Electron
;
Perfusion
;
Phosphates/*metabolism
;
Rats
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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