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  • pharmacogenetics  (2)
  • Humans  (1)
  • *Transcription, Genetic
  • 1975-1979  (3)
  • 1
    Electronic Resource
    Electronic Resource
    Pharmacokinetic approach to intravenous procainamide therapy (1978)
    Springer
    European journal of clinical pharmacology 13 (1978), S. 303-308 
    Details
    ISSN: 1432-1041
    Keywords: Pharmacokinetics ; procainamide ; pharmacogenetics ; antiarrhythmic agent ; therapeutic serum concentrations ; constant rate infusion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary A pharmacokinetic approach was employed to design a dosing regimen for the i. v. use of procainamide (PA) which consisted of a loading infusion given over one hour followed by a maintenance infusion. Therapeutic serum concentrations of PA were achieved in less than 15 min, and toxic serum concentrations were avoided in 12 patients. A mean maximum serum concentration of PA of 5.78 mg/l was obtained with a loading infusion of 16.6 mg/min PA HCl. An average steady-state serum concentration of PA of 5.05 mg/l was obtained with a mean maintenance infusion of 222 mg/hour PA HCl. The total body clearance of PA in slow and fast acetylators averaged 31 and 43 l/h respectively. Use of PA in cardiac patients by i. v. infusion can be safe and effective therapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00716367
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Clinical pharmacokinetics of procainamide infusions in relation to acetylator phenotype (1979)
    Springer
    Journal of pharmacokinetics and pharmacodynamics 7 (1979), S. 69-85 
    Details
    ISSN: 1573-8744
    Keywords: procainamide ; pharmacokinetics ; constant-rate infusion ; acetylator phenotype ; pharmacogenetics ; renal impairment
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The pharmacokinetics of procainamide was determined in 21 lidocaine-resistant patients who received the drug according to a pharmacokinetically designed double-infusion technique. Thirteen patients were phenotyped as slow acetylators, seven as fast, and one as intermediate. The total body clearances (ClT) of PA in slow and fast acetylators were 22.6 and 34.8 liters/hr, respectively. The fraction of PA cleared by the formation of NAPA in the corresponding acetylator group was 0.2 and 0.4. Renal impairment affected the pharmacokinetics of PA more profoundly as the ClTs of PA in patients with and without renal impairment were 17.9 and 31.2 liters/hr, respectively. None of the calculated volumes of distribution was affected by acetylator phenotype or renal impairment. These data identify the contribution of at least two of the major factors accounting for variability in PA disposition in patients undergoing therapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01059442
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  • 3
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    Dopamine-related tetrahydroisoquinolines: significant urinary excretion by alcoholics after alcohol consumption (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-12-07
    Description: Concentrations of dopamine-related tetrahydroisoquinolines (salsolinol and O-methylated salsolinol) were significantly higher in the daily urine samples of alcoholic subjects admitted for alcohol detoxification than in the daily urine samples of nonalcoholic control subjects. Salsolinol concentrations in alcoholic subjects appeared to drop to trace (control) values 2 to 3 days after admission, following the disappearance of ethanol and its reactive metabolite acetaldehyde from the blood. These results indicate that physiologically active tetrahydroisoquinolines increase in humans during long-term alcohol consumption, presumably because of acetaldehyde's direct condensation with catecholamines. The presence of these or similar condensation products in the urine could be useful as clinical indicators of prior blood acetaldehyde concentrations in chronic alcoholics.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Collins, M A -- Nijm, W P -- Borge, G F -- Teas, G -- Goldfarb, C -- New York, N.Y. -- Science. 1979 Dec 7;206(4423):1184-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/505002" target="_blank"〉PubMed〈/a〉
    Keywords: Acetaldehyde/blood ; Adult ; Alcoholism/metabolism/*urine ; Dopamine/*metabolism ; Humans ; Isoquinolines/*urine ; Male ; Middle Aged ; Salsoline Alkaloids/urine ; Substance Withdrawal Syndrome/urine
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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