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  • bioavailability
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  • American Institute of Physics
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  • Springer Nature
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  • Springer  (1)
  • American Institute of Physics
  • Nature Publishing Group
  • Springer Nature
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    Electronic Resource
    Electronic Resource
    Bioavailability of 11 phenytoin products (1977)
    Springer
    Journal of pharmacokinetics and pharmacodynamics 5 (1977), S. 133-146 
    Details
    ISSN: 1573-8744
    Keywords: bioavailability ; phenytoin sodium capsules ; plasma levels ; human studies
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Eleven single lots of 100-mg phenytoin sodium capsules were evaluated for their relative bioavailability in 12 normal human volunteers. These products were manufactured by eight different companies and met all compendial specifications. The products were evaluated with respect to plasma levels at various times up to 96 hr following administration of single 100-mg doses, times of peak level, peak plasma concentrations, and areas under the plasma level—time curve. Several of the products exhibited statistically significant differences in the various parameters studied.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01066217
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