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  • Bone  (4)
  • mathematical programming  (3)
  • Springer  (7)
  • American Geophysical Union (AGU)
  • 1975-1979  (7)
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Keywords
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  • Springer  (7)
  • American Geophysical Union (AGU)
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Year
  • 1
    Electronic Resource
    Electronic Resource
    Preliminary studies on the binding of plasma albumin to bone tissue (1977)
    Springer
    Calcified tissue international 23 (1977), S. 303-305 
    Details
    ISSN: 1432-0827
    Keywords: Albumin ; Bone ; Hydroxyapatite ; Plasma protein
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary The extractability of125I-labelled plasma albumin from bone pieces and from powdered bone has been compared after both in vivo and in vitro incorporation. The results show that albumin is more readily extracted from bone pieces than from bone powder which implies that tissue disruption exposes additional protein adsorption sites. It is suggested that incorporation of plasma albumin into calcified matrix during bone formation occurs mainly as a result of its strong interaction with bone mineral.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02012801
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  • 2
    Electronic Resource
    Electronic Resource
    Plasma disappearance of rabbit α2 HS-glycoprotein and its uptake by bone tissue (1978)
    Springer
    Calcified tissue international 26 (1978), S. 155-161 
    Details
    ISSN: 1432-0827
    Keywords: Plasma protein ; Glycoprotein ; Bone ; Glucosamine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary Plasmaα 2HS-glycoprotein is specifically accumulated in calcified tissues. In the present studies this glycoprotein was isolated from plasma and after iodination with iodine-125 was injected intravenously into young rabbits. The tissue distribution and plasma disappearance rate of this radioactively labeled material were determined. Of the various tissues studied, bone showed the greatest retention of labeled glycoprotein expressed as percentage of the injected dose per gram tissue relative to the plasma content. The rate of loss of iodinatedα 2HS-glycoprotein from plasma was similar to that ofα 2HS-glycoprotein labeled endogenously by using14C-glucosamine or3H-glucosamine. The uptake of exogenously labeled3I-α 2HS-glycoprotein into bone tissue expressed as a percentage of the injected dose was similar to that of endogenously labeled14C-α 2HS-glycoprotein. These results suggest that the125I-labeled material can be used to study further the metabolism ofα 2HS-glycoprotein by bone tissue.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02013251
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  • 3
    Electronic Resource
    Electronic Resource
    Plasma proteins present in human cortical bone: Enrichment of theαHS-glycoprotein (1977)
    Springer
    Calcified tissue international 22 (1977), S. 27-33 
    Details
    ISSN: 1432-0827
    Keywords: Protein ; Bone ; Blood plasma ; Dentine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Abstract The spectrum of plasma proteins present in human cortical bone and permanent dentine has been determined. One plasma glycoprotein, theαHS-glycoprotein, was found to be present at a high concentration in both bone and dentine and was shown to be concentrated in the mineralized tissues with respect to the other plasma proteins by factors of between 30 and 100. In this respect theαHS-glycoprotein is analogous to the G2B-glycoprotein and α-glycoprotein of bovine and rabbit b one, respectively. The binding ofαHS-glycoprotein and albumin to calcium phosphates generated within serum samples has been studied at different serum: precipitate ratios. In each case all theαHS-glycoprotein was removed from the samples and theαHS-glycoprotein was concentrated with respect to albumin by factors ranging from 370 at the highest serum: precipitate ratio to 25 at the lowest ratio. The plasmaαHS-glycoprotein concentrations of patients with Paget's disease of bone were shown to be substantially lower than the normal range, with significant negative correlation between theαHS-glycoprotein concentration and the plasma alkaline phosphatase activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02010343
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  • 4
    Electronic Resource
    Electronic Resource
    Movement of125I albumin and125I polyvinylpyrrolidone through bone tissue fluid (1977)
    Springer
    Calcified tissue international 23 (1977), S. 103-112 
    Details
    ISSN: 1432-0827
    Keywords: Albumin ; Polyvinylpyrrolidone ; Tissue fluid ; Bone
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary The passage of tissue fluid through cortical bone has been investigated using radioactively labelled macromolecules as markers. The results suggest that in the cortex of young rabbit femur the movement of tissue fluid is in the same net direction as blood, mainly from the endosteal to the periosteal surface. Some albumin is incorporated from extravascular tissue fluid into calcified matrix at sites of bone formation. Polyvinylpyrrolidone, average molecular weight 35,000 is able to pass through extravascular tissue fluid in bone but isnot incorporated into calcified matrix. In rabbits made vitamin D deficient, much less albumin is retained in regions of bone formation than is the case with controls. Albumin adsorbs to the surface of calcium phosphate precipitates and it is suggested that this mechanism may be mainly responsible for its incorporation into bone.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02012773
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  • 5
    Electronic Resource
    Electronic Resource
    Solving the nonlinear least square problem: Application of a general method (1976)
    Springer
    Journal of optimization theory and applications 18 (1976), S. 469-483 
    Details
    ISSN: 1573-2878
    Keywords: Nonlinear least-square problems ; parameter optimization ; penalty function methods ; mathematical programming
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Abstract An algorithm for solving the general nonlinear least-square problem is developed. An estimate for the Hessian matrix is constructed as the sum of two matrices. The first matrix is the usual first-order estimate used by the Gauss method, while the second matrix is generated recursively using a rank-one formula. Test results indicate that the method is superior to the standard Gauss method and compares favorably with other methods, especially for problems with nonzero residuals at the solution.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00932656
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  • 6
    Electronic Resource
    Electronic Resource
    An accelerated multiplier method for nonlinear programming (1977)
    Springer
    Journal of optimization theory and applications 21 (1977), S. 137-174 
    Details
    ISSN: 1573-2878
    Keywords: Augmented penalty function ; method of multipliers ; penalty function methods ; nonlinear programming ; mathematical programming
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Abstract This paper describes an accelerated multiplier method for solving the general nonlinear programming problem. The algorithm poses a sequence of unconstrained optimization problems. The unconstrained problems are solved using a rank-one recursive algorithm described in an earlier paper. Multiplier estimates are obtained by minimizing the error in the Kuhn-Tucker conditions using a quadratic programming algorithm. The convergence of the sequence of unconstrained problems is accelerated by using a Newton-Raphson extrapolation process. The numerical effectiveness of the algorithm is demonstrated on a relatively large set of test problems.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00932517
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  • 7
    Electronic Resource
    Electronic Resource
    An improved penalty function method for solving constrained parameter optimization problems (1975)
    Springer
    Journal of optimization theory and applications 16 (1975), S. 1-24 
    Details
    ISSN: 1573-2878
    Keywords: Penalty-function methods ; mathematical programming ; nonlinear programming ; pseudo Newton-Raphson methods ; parameter optimization
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Abstract An effective algorithm is described for solving the general constrained parameter optimization problem. The method is quasi-second-order and requires only function and gradient information. An exterior point penalty function method is used to transform the constrained problem into a sequence of unconstrained problems. The penalty weightr is chosen as a function of the pointx such that the sequence of optimization problems is computationally easy. A rank-one optimization algorithm is developed that takes advantage of the special properties of the augmented performance index. The optimization algorithm accounts for the usual difficulties associated with discontinuous second derivatives of the augmented index. Finite convergence is exhibited for a quadratic performance index with linear constraints; accelerated convergence is demonstrated for nonquadratic indices and nonlinear constraints. A computer program has been written to implement the algorithm and its performance is illustrated in fourteen test problems.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00935620
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