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  • Rats  (8)
  • American Association for the Advancement of Science (AAAS)  (8)
  • 1975-1979  (8)
Collection
Keywords
Publisher
  • American Association for the Advancement of Science (AAAS)  (8)
  • Springer  (1)
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Year
  • 1
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    Blood-brain neutral amino acid transport activity is increased after portacaval anastomosis (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-06-23
    Description: In rats after portacaval anastomosis (an animal model of chronic liver disease), transport of tryptophan and other members of the large neutral amino acid group from blood to brain was markedly enhanced. Increased transport activity was apparently restricted to the neutral amino acid transport system, since brain uptake of glucose, inulin, and tyramine was unaffected while blood-brain arginine transport was significantly reduced. These results strikingly confirm the hypothesis that carrier-mediated blood-brain transport is the limiting factor determining the availability of the neutral amino acids to the brain. The encephalopathy associated with cirrhosis may be the result of abnormal neurotransmitter metabolism and neurotransmission secondary to increased neutral amino acid transport activity and an increased brain content of members of the neutral amino acid group.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉James, J H -- Escourrou, J -- Fischer, J E -- New York, N.Y. -- Science. 1978 Jun 23;200(4348):1395-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/663619" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acids/*metabolism ; Animals ; Arginine/metabolism ; *Blood-Brain Barrier ; Brain/*metabolism ; Female ; Glucose/metabolism ; Insulin/metabolism ; Liver Cirrhosis, Alcoholic/metabolism ; Phenylalanine/metabolism ; *Portacaval Shunt, Surgical ; Rats ; Tryptophan/*metabolism ; Tyramine/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Behavioral competition: a mechanism for schedule interactions (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-10-27
    Description: Rats pressing a lever for food reinforcement showed large positive-contrast effects when provided with the opportunity for a competing wheel-running response. Positive and negative behavioral contrast may reflect reallocation of competing interim and terminal responses between schedule components following changes in the reinforcement conditions in one component.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hinson, J M -- Staddon, J E -- New York, N.Y. -- Science. 1978 Oct 27;202(4366):432-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/705334" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Behavior, Animal/*physiology ; Conditioning (Psychology)/physiology ; Male ; Motor Activity/physiology ; Rats ; *Reinforcement (Psychology) ; Reinforcement Schedule
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Inhibition of bone resorption in vitro by a cartilage-derived anticollagenase factor (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-03-24
    Description: A cartilage-derived factor containing a specific collagenous inhibitor was found to block reversibly parathyroid hormone-stimulated 45Ca release from fetal rat bone in vitro. Morphologic and quantitative histometric examination revealed that this factor modulates osteoclastic activities.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Horton, J E -- Wezeman, F H -- Kuettner, K E -- New York, N.Y. -- Science. 1978 Mar 24;199(4335):1342-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/204011" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bone Resorption/*drug effects ; Calcium/metabolism ; Cartilage/*metabolism ; Enzyme Inhibitors/pharmacology ; Microbial Collagenase/*antagonists & inhibitors ; Organ Culture Techniques ; Osteoclasts/physiology/ultrastructure ; Parathyroid Hormone/antagonists & inhibitors ; Rats
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
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    Long-term treatment with lithium prevents the development of dopamine receptor supersensitivity (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-07-14
    Description: Long-term treatment of rats with haloperidol produced an increased sensitivity to the locomotor and stereotypic effect of apomorphine. This behavioral dopaminergic supersensitivity was accompanied by increased binding of [3H] spiroperidol in the striatum. Rats treated concurrently with lithium and haloperidol failed to develop both behavioral sensitivity to apomorphine and increased striatal dopamine receptor binding. The ability of lighium to prevent recurrent manicdepressive episodes may be related, in part, to its ability to stabilize dopaminergic receptor sensitivity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pert, A -- Rosenblatt, J E -- Sivit, C -- Pert, C B -- Bunney, W E Jr -- New York, N.Y. -- Science. 1978 Jul 14;201(4351):171-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/566468" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Apomorphine/pharmacology ; Corpus Striatum/metabolism ; Haloperidol/pharmacology ; Humans ; Lithium/*pharmacology ; Male ; Rats ; Receptors, Dopamine/*drug effects/metabolism ; Spiperone/metabolism ; Stereotyped Behavior/drug effects ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
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    Novel activation mechanism for the promutagenic herbicide diallate (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-09-07
    Description: The potent bacterial mutagen 2-chloroacrolein is formed from the carcinogenic herbicide S-2,3-dichloroallyl diisopropylthiocarbamate (diallate) on incubation with hepatic microsomal monooxygenases or on reaction with m-chloroperbenzoic acid. A proposed activation mechanism for this promutagen involves sulfoxidation followed by [2,3] sigmatropic rearrangement and 1,2-elimination reactions. A portion of the highly reactive intermediate, diallate sulfoxide (proximate mutagens), is attacked by glutathione in a reaction which competes with its transformation to the ultimate mutagen, 2-chloroacrolein.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schuphan, I -- Rosen, J D -- Casida, J E -- New York, N.Y. -- Science. 1979 Sep 7;205(4410):1013-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/472719" target="_blank"〉PubMed〈/a〉
    Keywords: Acrolein/pharmacology ; Animals ; Biotransformation ; Herbicides/*metabolism/pharmacology ; Mice ; Microsomes, Liver/metabolism ; *Mutagens ; Mutation/drug effects ; Rats ; Thiocarbamates/*metabolism/pharmacology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 6
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    Serotonin neurons project to small blood vessels in the brain (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-10-05
    Description: Electrolytic lesions of the nucleus raphe dorsalis and medianus reduce the concentration of serotonin (5-hydroxytryptamine) within rat brain intraparenchymal blood vessels. The concentration of serotonin within these vessels increases or decreases after the administration of drugs that modify the biosynthesis and degradation of serotonin or destroy nerve terminals by an uptake-dependent mechanism. These studies provide evidence for the existence of a serotonin-containing pathway seemingly analogous to the neuronal projection that terminates on small parenchymal blood vessels from noradrenergic neurons of the locus coeruleus.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Reinhard, J F Jr -- Liebmann, J E -- Schlosberg, A J -- Moskowitz, M A -- New York, N.Y. -- Science. 1979 Oct 5;206(4414):85-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/482930" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain/*blood supply ; Brain Mapping ; Brain Stem/*physiology ; Cerebrovascular Circulation ; Microcirculation/*innervation ; Raphe Nuclei/cytology/*physiology ; Rats ; Serotonin/*physiology ; Tryptophan Hydroxylase/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 7
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    Increasing adipocyte number as the basis for perirenal depot growth in adult rats (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-09-29
    Description: The mass of the perirenal adipose depot in male Fischer 344 rats increases between 6 and 18 months of age. This increase is due to an increase in the number of adipocytes in this depot, in contrast with the concept that adipocyte number is constant throughout adult life. The epididymal depot increases in mass between 6 and 18 months of age by adipocyte hypertrophy alone.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bertrand, H A -- Masoro, E J -- Yu, B P -- New York, N.Y. -- Science. 1978 Sep 29;201(4362):1234-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/151328" target="_blank"〉PubMed〈/a〉
    Keywords: Adipose Tissue/*cytology ; Animals ; Epididymis ; Kidney ; Male ; Rats ; Rats, Inbred F344 ; Specific Pathogen-Free Organisms
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 8
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    Intracerebral adrenocorticotropic hormone mediates novelty-induced grooming in the rat (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-01-19
    Description: Intact male rats exhibited more grooming in unfamiliar testing chambers than in their home cages. Hypophysectomized rats showed a much reduced increase in grooming in these testing chambers. Intraventricular injections of antiserum to adrenocorticotropic hormone to intact rats decreased the grooming usually observed in the novel situation, whereas a similar injection of control serum did not produce this effect. Peripheral injections of the antiserum did not affect grooming. Since intraventricularly injected adrenocorticotropic hormone induces excessive grooming, these results suggest that the increased grooming observed in the novel environment may be at least partly due to the release of this hormone directly into the cerebral ventricular system.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dunn, A J -- Green, E J -- Isaacson, R L -- New York, N.Y. -- Science. 1979 Jan 19;203(4377):281-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/216073" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenocorticotropic Hormone/*cerebrospinal fluid/immunology/pharmacology ; Animals ; Antigen-Antibody Reactions ; Grooming/drug effects/*physiology ; Humans ; Hypophysectomy ; Male ; Rats ; Stress, Psychological
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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