Publication Date:
1978-09-08
Description:
Fibroblasts from New Zealand Black mouse fetuses manifest increased frequency of chromosomal breaks and interchanges after exposure to ultraviolet radiation when compared with cells from BABL/c fetuses. This chromosomal instability is similar to what has been reported in cells from patients with xeroderma pigmentosum and may be related to the chromosomally abnormal clones and malignancy previously reported in adult New Zealand Black mice.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Reddy, A L -- Fialkow, P G -- Salo, A -- New York, N.Y. -- Science. 1978 Sep 8;201(4359):920-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/684417" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Cells, Cultured
;
*Chromosome Aberrations
;
Chromosomes/*radiation effects
;
Disease Models, Animal
;
Dose-Response Relationship, Radiation
;
Mice
;
Mice, Inbred BALB C/physiology
;
Mice, Inbred NZB/*physiology
;
*Ultraviolet Rays
;
Xeroderma Pigmentosum/physiopathology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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