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  • Animals  (14)
  • Cell Line
  • Crystallography, X-Ray
  • American Association for the Advancement of Science (AAAS)  (14)
  • 1975-1979  (14)
Collection
Keywords
Publisher
  • American Association for the Advancement of Science (AAAS)  (14)
Years
Year
  • 1
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    Functional plasticity in the immature striate cortex of the monkey shown by the [14C]deoxyglucose method (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-04-28
    Description: Autoradiographic representation of the local rates of cerebral glucose utilization and local cerebral functional activity by means of the [14C]deoxyglucose technique reveals the existence of the ocular dominance columns in the striate cortex of the monkey in the first day of life. In contrast to the stability of these columns in more mature brain, monocular deprivation for 3 months from the first day of life results in their complete disappearance and a reversion of the autoradiographic pattern to that seen in animals with normal binocular vision. These results are consistent with a reorganization of the representation of the visual fields of the two eyes in the striate cortex and provide additional evidence of the plasticity of the striate cortex of the monkey in early life.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Des Rosiers, M H -- Sakurada, O -- Jehle, J -- Shinohara, M -- Kennedy, C -- Sokoloff, L -- New York, N.Y. -- Science. 1978 Apr 28;200(4340):447-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/417397" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Animals, Newborn/physiology ; Brain Mapping ; Cell Differentiation ; Deoxy Sugars/*metabolism ; Deoxyglucose/*metabolism ; Female ; Haplorhini ; Male ; Vision, Ocular ; Visual Cortex/*cytology/physiology ; Visual Pathways/*cytology/physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Phagocytosis of light- and dark-adapted rod outer segments by cultured pigment epithelium (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-11-03
    Description: Pigment epithelial cells in culture retain their ability to phagocytize rod outer segments. These cells phagocytize rod outer segments isolated from light-adapted rats, or from dark-adapted rats killed after the time at which the lights would normally be turned on. However, they phagocytize for fewer rod outer segments prepared in the dark from the retinas of rats killed before the onset of the normal light cycle. Phagocytosis of dark rod outer segments is variable, but that of light outer segments is reproducible. It is postulated that the effect of light is to synchronize the chemical events that occur at the surface of the rods to prepare them for phagocytosis. These processes also occur in the dark, but more slowly and irregularly than in the light.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hall, M O -- New York, N.Y. -- Science. 1978 Nov 3;202(4367):526-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/568310" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Culture Techniques ; Dark Adaptation ; Energy Metabolism ; Light ; Phagocytosis ; Photoreceptor Cells/*physiology ; Pigment Epithelium of Eye/*physiology/ultrastructure ; Rats
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Trisodium phosphonoformate, a new antiviral compound (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-09-01
    Description: Trisodium phosphonoformate selectively inhibits cell-free DNA polymerase activity induced by herpesvirus. The new inhibitor has an antiviral effect on herpes simplex virus types 1 and 2, pseudorables virus, and infectious bovine rhinotracheitis virus in cell culture. It has a good therapeutic activity against cutaneous herpes simplex virus infection in guinea pigs.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Helgstrand, E -- Eriksson, B -- Johansson, N G -- Lannero, B -- Larsson, A -- Misiorny, A -- Noren, J O -- Sjoberg, B -- Stenberg, K -- Stening, G -- Stridh, S -- Oberg, B -- New York, N.Y. -- Science. 1978 Sep 1;201(4358):819-21.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/210500" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Antiviral Agents/therapeutic use/toxicity ; Cell Line ; DNA-Directed RNA Polymerases/*antagonists & inhibitors ; Formates/pharmacology/toxicity ; Guinea Pigs ; Herpesviridae Infections/drug therapy ; *Nucleic Acid Synthesis Inhibitors ; Organophosphorus Compounds/*pharmacology/toxicity ; Phosphonoacetic Acid/pharmacology ; Simplexvirus/enzymology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Cloning human fetal gamma globin and mouse alpha-type globin DNA: preparation and screening of shotgun collections (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-12-22
    Description: Shotgun collections of Charon 3A bacteriophages containing Eco RI fragments of human and mouse DNA were constructed with the use of in vitro packaging. Plaques were screened by hybridization, and globin-specific clones were isolated from both human (Charon 3AHs51.1) and mouse (Charon 3AMm30.5). The fragments cloned were detected in unfractionated genomic DNA by the Southern method of hybridization.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Blattner, F R -- Blechl, A E -- Denniston-Thompson, K -- Faber, H E -- Richards, J E -- Slightom, J L -- Tucker, P W -- Smithies, O -- New York, N.Y. -- Science. 1978 Dec 22;202(4374):1279-84.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/725603" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Coliphages/genetics ; DNA Restriction Enzymes ; DNA, Recombinant ; Fetal Hemoglobin/genetics ; *Genes ; Globins/*genetics ; Humans ; Methods ; Mice ; Nucleic Acid Hybridization ; Poly A ; Poly T
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    Thyroid gangliosides with high affinity for thyrotropin: potential role in thyroid regulation (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-01-06
    Description: Thyroid cell membranes contain a multiplicity of gangliosides, some of which inhibit thyrotropin binding to thyroid membranes. The most potent inhibitor is a ganglioside which is present in only trace amounts and appears to have a novel structure. Thyroid gangliosides may play a role in relaying the hormonal message to the thyroid cell.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mullin, B R -- Pacuszka, T -- Lee, G -- Kohn, L D -- Brady, R O -- Fishman, P H -- New York, N.Y. -- Science. 1978 Jan 6;199(4324):77-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Biochemical Pharmacology, National Institute of Arthritis, Metabolism, and Digestive Diseases, Bethesda, MD 20014, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17569488" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cattle ; Cell Membrane/metabolism ; Gangliosides/chemistry/*metabolism/pharmacology ; Sialic Acids/analysis ; Thyroid Gland/*metabolism ; Thyrotropin/antagonists & inhibitors/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 6
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    The LDH virus: an interfering biological contaminant (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-04-14
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Riley, V -- Spackman, D H -- Santisteban, G A -- Dalldorf, G -- Hellstrom, I -- Hellstrom, K E -- Lance, E M -- Rowson, K E -- Mahy, B W -- Alexander, P -- Stock, C C -- Sjogren, H O -- Hollander, V P -- Horzinek, M C -- New York, N.Y. -- Science. 1978 Apr 14;200(4338):124-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/263259" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Lactate dehydrogenase-elevating virus ; Mice ; Neoplasm Transplantation ; Neoplasms, Experimental/microbiology ; Virus Diseases/microbiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 7
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    A harvester ant venom: chemistry and pharmacology (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-06-02
    Description: The mammalian toxicity of the potently algogenic venom of the ant Pogonomyrmex badius is greater than that reported for any other insect venom. This enzyme-rich venom contains high concentrations of phospholipase A2 and B, hyaluronidase, acid phosphatase, lipase, and esterases. This hemolytic secretion from the poison gland products unusual symptoms in mammals and appears to have been evolved as a deterrent for vertebrate predators.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schmidt, J O -- Blum, M S -- New York, N.Y. -- Science. 1978 Jun 2;200(4345):1064-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/653354" target="_blank"〉PubMed〈/a〉
    Keywords: Acid Phosphatase/metabolism ; Animals ; Ant Venoms/analysis/*toxicity ; Arthropod Venoms/*toxicity ; Esterases/metabolism ; Hemolysin Proteins/*analysis ; Heparin/pharmacology ; Hyaluronoglucosaminidase/metabolism ; Lethal Dose 50 ; Lipase/metabolism ; Mice ; Phospholipases/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 8
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    Induction of ovalbumin synthesis in immature chicks by actinomycin D and thioacetamide (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-10-06
    Description: Actinomycin D and thioacetamide induced ovalbumin synthesis and increased serum progesterone concentrations in immature chicks. The increase in progesterone induced by the carcinogens actinomycin D and thioacetamide may account for the induction of ovalbumin synthesis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sharma, O K -- New York, N.Y. -- Science. 1978 Oct 6;202(4363):68-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/694521" target="_blank"〉PubMed〈/a〉
    Keywords: Acetamides/*pharmacology ; Animals ; Dactinomycin/*pharmacology ; Ovalbumin/*biosynthesis ; Progesterone/*blood ; Thioacetamide/*pharmacology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 9
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    Cloning human fetal gamma globin and mouse alpha-type globin DNA: characterization and partial sequencing (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-12-22
    Description: Two globin-related clones isolated from collections of bacteriophages containing unfractionated Eco RI fragments of human and mouse DNA were characterized. Charon3AHs51.1Hbgamma includes 2.7 kilobase pairs of human DNA containing a large part of a fetal gamma globin chain structural gene; Charon 3AMm30.5 includes 4.7 kilobase pairs of mouse DNA related to alpha globin. The human fetal gamma globin gene has within its coding region two intervening sequences of noncoding DNA, IVS 1 and IVS 2, of approximately 1-0 and 900 base pairs. Sequence IVS 1 is located at the position of one of the two intervening sequences occurring in adult globin genes; IVS 2 is located at the position of the other.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Smithies, O -- Blechl, A E -- Denniston-Thompson, K -- Newell, N -- Richards, J E -- Slightom, J L -- Tucker, P W -- Blattner, F R -- New York, N.Y. -- Science. 1978 Dec 22;202(4374):1284-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/725604" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Base Sequence ; Codon ; DNA Restriction Enzymes/metabolism ; DNA, Recombinant ; Fetal Hemoglobin/*genetics ; *Genes ; Globins/*genetics ; Humans ; Methods ; Mice ; Nucleic Acid Hybridization ; RNA, Messenger/genetics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 10
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    Dopaminergic inhibition of adrenergic neurotransmission as a model for studies on dopamine receptor mechanisms (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-01-27
    Description: Dopamine and apomorphine produced concentration-dependent inhibition of adrenergic neurotransmission in the isolated, perfused, rabbit ear artery. The inhibitory action of both dopamine and apomorphine was competitively antagonized by haloperidol and several other antipsychotic drugs. The calculated affinities of these drugs for the dopaminergic receptor correlate closely with both the pharmacological potencies of these drugs in vivo and their reported potencies as inhibitors of [3H]haloperidol binding to "dopamine receptors" in brain homogenates.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Steinsland, O S -- Hieble, J P -- New York, N.Y. -- Science. 1978 Jan 27;199(4327):443-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22933" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antipsychotic Agents/*pharmacology ; Apomorphine/pharmacology ; Dopamine/*pharmacology ; Ear/blood supply ; Haloperidol/pharmacology ; Kinetics ; Neuromuscular Junction/drug effects ; Norepinephrine/metabolism ; Rabbits ; Receptors, Dopamine/*drug effects ; Synaptic Transmission/*drug effects ; Vasoconstriction/drug effects
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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