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  • Rats  (57)
  • United States  (21)
  • ASTROPHYSICS
  • Chemistry
  • STRUCTURAL MECHANICS
  • American Association for the Advancement of Science (AAAS)  (77)
  • 1975-1979  (77)
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Keywords
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Year
  • 1
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    A direct role of dopamine in the rat subthalamic nucleus and an adjacent intrapeduncular area (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-12-21
    Description: The subthalamic nucleus, a clinically important component of the extrapyramidal motor system, and a lateral area extending into the peduncle contain catecholamine terminals and dopamine receptors coupled to adenylate cyclase. In addition, dopamine agonists administered in vivo enhance glucose utilization in the region. Thus, neuronal function in this region is directly affected by dopamine and dopaminergic drugs.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brown, L L -- Markman, M H -- Wolfson, L I -- Dvorkin, B -- Warner, C -- Katzman, R -- New York, N.Y. -- Science. 1979 Dec 21;206(4425):1416-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/505015" target="_blank"〉PubMed〈/a〉
    Keywords: Adenylyl Cyclases/metabolism ; Animals ; Brain Mapping ; Catecholamines/pharmacology ; Dopamine/pharmacology ; Enzyme Activation/drug effects ; Extrapyramidal Tracts/*metabolism/ultrastructure ; Glucose/metabolism ; Male ; Mesencephalon/*metabolism ; Neurons/metabolism ; Rats ; Receptors, Dopamine/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Increased resistance to Staphylococcus aureus infection and enhancement in serum lysozyme activity by glucan (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-03-24
    Description: Glucan is a potent reticuloendothelial stimulant whose immunobiological activity is mediated, in part, by an increase in the number and function of macrophages. In studying the role of glucan as a mediator of antibacterial activity, we attempted to ascertain the ability of glucan to modify the mortality of mice with experimentally induced Gram-positive bacteremia, and to enhance antibacterial defenses in rats as denoted by serum lysozyme and phagocytic activity. After intravenous administration of glucan, serum lysozyme concentrations were increased approximately sevenfold over control concentrations. The increase in serum lysozyme appeared to parallel the glucan-induced increase in phagocytosis and induced hyperplasia of macrophages. Prior treatment of mice with glucan significantly enhanced their survival when they were challenged systemically with Staphylococcus aureus. These studies indicate that glucan confers an enhanced state of host defense against bacterial infections.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kokoshis, P L -- Williams, D L -- Cook, J A -- Di Luzio, N R -- New York, N.Y. -- Science. 1978 Mar 24;199(4335):1340-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/628841" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bacteriolysis/drug effects ; Immunotherapy ; Macrophages/drug effects ; Male ; Muramidase/*blood ; Phagocytosis/*drug effects ; Polysaccharides/*pharmacology/therapeutic use ; Rats ; Sepsis/prevention & control ; Staphylococcal Infections/*prevention & control/therapy ; Staphylococcus aureus
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Intracellular translocation of iodine-125-labeled insulin: direct demonstration in isolated hepatocytes (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-05-19
    Description: Insulin labeled with iodine-125 binds to receptors on isolated rat hepatocytes. At low temperatures initial binding is restricted to the plasma membrane as detected by direct quantitative autoradiographic analysis with the electron microscope. With increasing time and temperature of incubation there is a systematic and progressive translocation of autoradiographic grains to a highly limited area of the cell periphery representing no more than 15% of the radius of the cell.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gorden, P -- Carpentier, J L -- Freychet, P -- LeCam, A -- Orci, L -- New York, N.Y. -- Science. 1978 May 19;200(4343):782-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/644321" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Membrane/metabolism ; Endocytosis ; Insulin/*metabolism ; Kinetics ; Liver/*metabolism/ultrastructure ; Lymphocytes/metabolism ; Lysosomes/metabolism ; Molecular Weight ; Rats ; Receptor, Insulin/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Somatostatin cell processes as pathways for paracrine secretion (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-09-28
    Description: Somatostatin is produced by gastrointestinal endocrine cells that have long, nonluminal, cytoplasmic processes. Such processes terminate on other cell types, including gastrin-producing and hydrochloric acid-producing cells, whose functions are profoundly affected by somatostatin. The findings suggest that somatostatin cells control the functions of other cells through local release of the peptide by way of cytoplasmic processes. Also, certain other types of gastrointestinal endocrine cells have similar cytoplasmic prolongations, which may have analogous local (paracrine) regulatory functions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Larsson, L I -- Goltermann, N -- de Magistris, L -- Rehfeld, J F -- Schwartz, T W -- New York, N.Y. -- Science. 1979 Sep 28;205(4413):1393-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/382360" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Gastric Juice/*secretion ; Gastrins/secretion ; Humans ; Immunoenzyme Techniques ; Pyloric Antrum/cytology/*metabolism ; Rats ; Somatostatin/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    Metabolic mapping of functional activity in the hypothalamo-neurohypophysial system of the rat (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-08-17
    Description: Physiological stimulation of the hypothalamo-neurohypophysial system by salt loading of rats resulted in a dramatically increased glucose utilization in the posterior pituitary but not in the paraventricular or supraoptic nuclei. The good correlation between glucose utilization and neural activity in the posterior pituitary (that is, nerve terminals) contrasted with the lack of correlation in the paraventricular and supraoptic nuclei (that is, the sites of the cell bodies of the same neurons). This difference in the metabolic response to functional activity between the two regions of these neurons can be explained by the differences in surface-to-volume ratios of these regions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schwartz, W J -- Smith, C B -- Davidsen, L -- Savaki, H -- Sokoloff, L -- Mata, M -- Fink, D J -- Gainer, H -- New York, N.Y. -- Science. 1979 Aug 17;205(4407):723-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/462184" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Axons/metabolism ; Deoxyglucose/metabolism ; *Energy Metabolism/drug effects ; Hypothalamo-Hypophyseal System/*metabolism ; Male ; Nerve Endings/metabolism ; Paraventricular Hypothalamic Nucleus/metabolism ; Phenoxybenzamine/pharmacology ; Pituitary Gland, Posterior/metabolism ; Rats ; Supraoptic Nucleus/metabolism ; Water Deprivation ; Water-Electrolyte Balance
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 6
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    Regulators defend their turf (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-11-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Carter, L J -- New York, N.Y. -- Science. 1978 Nov 10;202(4368):603.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/705348" target="_blank"〉PubMed〈/a〉
    Keywords: Economics ; *Environmental Health ; Government Agencies ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 7
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    Uranium mill tailings: Congress addresses a long-neglected problem (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-10-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Carter, L J -- New York, N.Y. -- Science. 1978 Oct 13;202(4364):191-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/694524" target="_blank"〉PubMed〈/a〉
    Keywords: *Environmental Exposure ; Legislation as Topic ; Mining/*standards ; New Mexico ; United States ; *Uranium ; Utah
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 8
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    Changing postdoctoral career patterns for biomedical scientists (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-11-03
    Description: Between 1973 and 1977 the total number of Ph.D.'s holding postdoctoral appointments in the biomedical sciences increased at a rate of more than 550 individuals (12.5 percent) per year. During this same period the total number of doctorates awarded each year in these disciplines showed very little change. The postdoctoral growth can be attributed to substantial increases in both the numbers of recent graduates taking postdoctorals and the length of stay on these appointments. The lack of alternative employment opportunities has contributed heavily to the postdoctoral buildup. Continued growth is likely to have important consequences for biomedical research and research training.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Coggeshall, P E -- Norvell, J C -- Bogorad, L -- Bock, R M -- New York, N.Y. -- Science. 1978 Nov 3;202(4367):487-93.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/705338" target="_blank"〉PubMed〈/a〉
    Keywords: Biology/*manpower/trends ; Education, Continuing/*trends ; Employment ; *Research Support as Topic ; Salaries and Fringe Benefits ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 9
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    How valuable are scientific exchanges with the Soviet Union? (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-10-27
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Graham, L R -- New York, N.Y. -- Science. 1978 Oct 27;202(4366):383-90.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/705332" target="_blank"〉PubMed〈/a〉
    Keywords: *Foreign Professional Personnel ; *International Cooperation ; *Science ; Ussr ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 10
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    beta-Adrenergic receptors in aged rat brain: reduced number and capacity of pineal gland to develop supersensitivity (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-07-07
    Description: The density but not the affinity of beta-adrenergic receptors declined significantly with age in rat pineal gland, corpus striatum, and cerebellum, as determined by the binding of tritiated dihydroalprenolol. Exposing rats to light for 12 hours increased the binding of this radioligand in 3-month-old but not in 24-month-old rats. The reduced responsiveness to catecholamines seen in aging may be due to a decrease in the number of beta-adrenergic receptors which, in turn, may be caused by an impaired capacity of receptors in aged animals to adapt to changes in adrenergic neuronal input.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Greenberg, L H -- Weiss, B -- New York, N.Y. -- Science. 1978 Jul 7;201(4350):61-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/208145" target="_blank"〉PubMed〈/a〉
    Keywords: *Aging ; Alprenolol/analogs & derivatives/metabolism ; Animals ; Brain/*metabolism ; Cerebellum/metabolism ; Circadian Rhythm ; Corpus Striatum/metabolism ; Kinetics ; Light ; Male ; Neuroglia/metabolism ; Pineal Gland/*metabolism ; Rats ; Receptors, Adrenergic/*metabolism ; Receptors, Adrenergic, beta/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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