Publication Date:
1992-12-18
Description:
Mice with mutations in four nonreceptor tyrosine kinase genes, fyn, src, yes, and abl, were used to study the role of these kinases in long-term potentiation (LTP) and in the relation of LTP to spatial learning and memory. All four kinases were expressed in the hippocampus. Mutations in src, yes, and abl did not interfere with either the induction or the maintenance of LTP. However, in fyn mutants, LTP was blunted even though synaptic transmission and two short-term forms of synaptic plasticity, paired-pulse facilitation and post-tetanic potentiation, were normal. In parallel with the blunting of LTP, fyn mutants showed impaired spatial learning, consistent with a functional link between LTP and learning. Although fyn is expressed at mature synapses, its lack of expression during development resulted in an increased number of granule cells in the dentate gyrus and of pyramidal cells in the CA3 region. Thus, a common tyrosine kinase pathway may regulate the growth of neurons in the developing hippocampus and the strength of synaptic plasticity in the mature hippocampus.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Grant, S G -- O'Dell, T J -- Karl, K A -- Stein, P L -- Soriano, P -- Kandel, E R -- AG08702/AG/NIA NIH HHS/ -- HD24875/HD/NICHD NIH HHS/ -- MH45923/MH/NIMH NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1992 Dec 18;258(5090):1903-10.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for Neurobiology and Behavior, Howard Hughes Medical Institute, College of Physicians and Surgeons, Columbia University, New York, NY 10032.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1361685" target="_blank"〉PubMed〈/a〉
Keywords:
2-Amino-5-phosphonovalerate/pharmacology
;
Acetylcholinesterase/analysis
;
Animals
;
Brain/cytology/*physiology
;
Cerebral Cortex/cytology/physiology
;
Electric Stimulation
;
Genes, abl
;
Genes, src
;
Hippocampus/drug effects/growth & development/*physiology
;
In Vitro Techniques
;
*Learning
;
Mice
;
Mice, Neurologic Mutants
;
Neurons/drug effects/*physiology
;
Protein-Tyrosine Kinases/*genetics/metabolism
;
Proto-Oncogene Proteins/*genetics/metabolism
;
Proto-Oncogene Proteins c-fyn
;
Proto-Oncogene Proteins c-yes
;
Pyramidal Tracts/physiology
;
Receptors, N-Methyl-D-Aspartate/physiology
;
Space Perception
;
Synapses/physiology
;
*src-Family Kinases
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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