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  • Rats  (57)
  • ASTROPHYSICS
  • Chemistry
  • STRUCTURAL MECHANICS
  • American Association for the Advancement of Science (AAAS)  (57)
  • Boston, MA : Springer
  • 1975-1979  (57)
Collection
Keywords
Publisher
Years
Year
  • 1
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    A direct role of dopamine in the rat subthalamic nucleus and an adjacent intrapeduncular area (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-12-21
    Description: The subthalamic nucleus, a clinically important component of the extrapyramidal motor system, and a lateral area extending into the peduncle contain catecholamine terminals and dopamine receptors coupled to adenylate cyclase. In addition, dopamine agonists administered in vivo enhance glucose utilization in the region. Thus, neuronal function in this region is directly affected by dopamine and dopaminergic drugs.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brown, L L -- Markman, M H -- Wolfson, L I -- Dvorkin, B -- Warner, C -- Katzman, R -- New York, N.Y. -- Science. 1979 Dec 21;206(4425):1416-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/505015" target="_blank"〉PubMed〈/a〉
    Keywords: Adenylyl Cyclases/metabolism ; Animals ; Brain Mapping ; Catecholamines/pharmacology ; Dopamine/pharmacology ; Enzyme Activation/drug effects ; Extrapyramidal Tracts/*metabolism/ultrastructure ; Glucose/metabolism ; Male ; Mesencephalon/*metabolism ; Neurons/metabolism ; Rats ; Receptors, Dopamine/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Increased resistance to Staphylococcus aureus infection and enhancement in serum lysozyme activity by glucan (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-03-24
    Description: Glucan is a potent reticuloendothelial stimulant whose immunobiological activity is mediated, in part, by an increase in the number and function of macrophages. In studying the role of glucan as a mediator of antibacterial activity, we attempted to ascertain the ability of glucan to modify the mortality of mice with experimentally induced Gram-positive bacteremia, and to enhance antibacterial defenses in rats as denoted by serum lysozyme and phagocytic activity. After intravenous administration of glucan, serum lysozyme concentrations were increased approximately sevenfold over control concentrations. The increase in serum lysozyme appeared to parallel the glucan-induced increase in phagocytosis and induced hyperplasia of macrophages. Prior treatment of mice with glucan significantly enhanced their survival when they were challenged systemically with Staphylococcus aureus. These studies indicate that glucan confers an enhanced state of host defense against bacterial infections.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kokoshis, P L -- Williams, D L -- Cook, J A -- Di Luzio, N R -- New York, N.Y. -- Science. 1978 Mar 24;199(4335):1340-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/628841" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bacteriolysis/drug effects ; Immunotherapy ; Macrophages/drug effects ; Male ; Muramidase/*blood ; Phagocytosis/*drug effects ; Polysaccharides/*pharmacology/therapeutic use ; Rats ; Sepsis/prevention & control ; Staphylococcal Infections/*prevention & control/therapy ; Staphylococcus aureus
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
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    Intracellular translocation of iodine-125-labeled insulin: direct demonstration in isolated hepatocytes (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-05-19
    Description: Insulin labeled with iodine-125 binds to receptors on isolated rat hepatocytes. At low temperatures initial binding is restricted to the plasma membrane as detected by direct quantitative autoradiographic analysis with the electron microscope. With increasing time and temperature of incubation there is a systematic and progressive translocation of autoradiographic grains to a highly limited area of the cell periphery representing no more than 15% of the radius of the cell.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gorden, P -- Carpentier, J L -- Freychet, P -- LeCam, A -- Orci, L -- New York, N.Y. -- Science. 1978 May 19;200(4343):782-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/644321" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Membrane/metabolism ; Endocytosis ; Insulin/*metabolism ; Kinetics ; Liver/*metabolism/ultrastructure ; Lymphocytes/metabolism ; Lysosomes/metabolism ; Molecular Weight ; Rats ; Receptor, Insulin/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
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    Somatostatin cell processes as pathways for paracrine secretion (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-09-28
    Description: Somatostatin is produced by gastrointestinal endocrine cells that have long, nonluminal, cytoplasmic processes. Such processes terminate on other cell types, including gastrin-producing and hydrochloric acid-producing cells, whose functions are profoundly affected by somatostatin. The findings suggest that somatostatin cells control the functions of other cells through local release of the peptide by way of cytoplasmic processes. Also, certain other types of gastrointestinal endocrine cells have similar cytoplasmic prolongations, which may have analogous local (paracrine) regulatory functions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Larsson, L I -- Goltermann, N -- de Magistris, L -- Rehfeld, J F -- Schwartz, T W -- New York, N.Y. -- Science. 1979 Sep 28;205(4413):1393-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/382360" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Gastric Juice/*secretion ; Gastrins/secretion ; Humans ; Immunoenzyme Techniques ; Pyloric Antrum/cytology/*metabolism ; Rats ; Somatostatin/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
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    Metabolic mapping of functional activity in the hypothalamo-neurohypophysial system of the rat (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-08-17
    Description: Physiological stimulation of the hypothalamo-neurohypophysial system by salt loading of rats resulted in a dramatically increased glucose utilization in the posterior pituitary but not in the paraventricular or supraoptic nuclei. The good correlation between glucose utilization and neural activity in the posterior pituitary (that is, nerve terminals) contrasted with the lack of correlation in the paraventricular and supraoptic nuclei (that is, the sites of the cell bodies of the same neurons). This difference in the metabolic response to functional activity between the two regions of these neurons can be explained by the differences in surface-to-volume ratios of these regions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schwartz, W J -- Smith, C B -- Davidsen, L -- Savaki, H -- Sokoloff, L -- Mata, M -- Fink, D J -- Gainer, H -- New York, N.Y. -- Science. 1979 Aug 17;205(4407):723-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/462184" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Axons/metabolism ; Deoxyglucose/metabolism ; *Energy Metabolism/drug effects ; Hypothalamo-Hypophyseal System/*metabolism ; Male ; Nerve Endings/metabolism ; Paraventricular Hypothalamic Nucleus/metabolism ; Phenoxybenzamine/pharmacology ; Pituitary Gland, Posterior/metabolism ; Rats ; Supraoptic Nucleus/metabolism ; Water Deprivation ; Water-Electrolyte Balance
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
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    beta-Adrenergic receptors in aged rat brain: reduced number and capacity of pineal gland to develop supersensitivity (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-07-07
    Description: The density but not the affinity of beta-adrenergic receptors declined significantly with age in rat pineal gland, corpus striatum, and cerebellum, as determined by the binding of tritiated dihydroalprenolol. Exposing rats to light for 12 hours increased the binding of this radioligand in 3-month-old but not in 24-month-old rats. The reduced responsiveness to catecholamines seen in aging may be due to a decrease in the number of beta-adrenergic receptors which, in turn, may be caused by an impaired capacity of receptors in aged animals to adapt to changes in adrenergic neuronal input.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Greenberg, L H -- Weiss, B -- New York, N.Y. -- Science. 1978 Jul 7;201(4350):61-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/208145" target="_blank"〉PubMed〈/a〉
    Keywords: *Aging ; Alprenolol/analogs & derivatives/metabolism ; Animals ; Brain/*metabolism ; Cerebellum/metabolism ; Circadian Rhythm ; Corpus Striatum/metabolism ; Kinetics ; Light ; Male ; Neuroglia/metabolism ; Pineal Gland/*metabolism ; Rats ; Receptors, Adrenergic/*metabolism ; Receptors, Adrenergic, beta/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 7
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    Immunoassay of androgen binding protein in blood: a new approach for study of the seminiferous tubule (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-04-07
    Description: Androgen binding protein, a secretory product of seminiferous tubules, was isolated by means of affinity chromatography. A radioimmunoassay was developed and used to identify androgen binding protein in rat plasma. The ability to measure a testicular protein in blood provides a new method for investigation of seminiferous tubular physiology.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gunsalus, G L -- Musto, N A -- Bardin, W -- New York, N.Y. -- Science. 1978 Apr 7;200(4337):65-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/635573" target="_blank"〉PubMed〈/a〉
    Keywords: Androgens/metabolism ; Animals ; Blood-Testis Barrier ; Carrier Proteins/*blood/metabolism ; Castration ; Male ; Molecular Weight ; Radioimmunoassay/methods ; Rats ; Seminiferous Tubules/*metabolism ; Testis/*metabolism ; Testosterone/pharmacology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 8
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    Morphine tolerance: is there evidence for a conditioning model? (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-04-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hayes, R L -- Mayer, D J -- New York, N.Y. -- Science. 1978 Apr 21;200(4339):343-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/635595" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Behavior, Animal/physiology ; Conditioning (Psychology)/*physiology ; *Drug Tolerance ; Morphine/*pharmacology ; Rats
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 9
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    Stimulation of dopamine synthesis in caudate nucleus by intrastriatal enkephalins and antagonism by naloxone (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-05-05
    Description: The intraventricular injection of methionine-enkephalin (50 to 100 micrograms) or [d-Ala2]-methionine-enkephalinamide (1.5 to 12 micrograms), a synthetic enkephalin analog resistant to enzyme degradation, caused a marked dose-dependent increase in dihydroxyphenylacetic acid and homovanillic acid concentrations in the rat striatum. The [d-Ala2] analog increased the accumulation of dopa in the striatum after aromatic amino acid decarboxylase inhibition, indicating that it increased dopamine synthesis. At the highest doses used both enkephalins failed to modify brain serotonin metabolism. The monolateral microinjection of the [d-Ala2]] analog (3 to 6 micrograms) into the caudate nucleus increased the concentration of dihydroxyphenylacetic acid in the injected side, whereas bilateral injection increased the concentration of this compound in both caudate nuclei and caused catalepsy. The stimulant effect of the [d-Ala2] analog on dopamine synthesis in the striatum persisted after destruction of striatal postsynaptic dopamine receptors with kainic acid. The biochemical and behavioral effects of enkephalins were prevented by naloxone, a specific narcotic antagonist. The results indicate that enkephalins stimulate dopamine synthesis by an action on opioid receptors localized on dopaminergic nerve terminals.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Biggio, G -- Casu, M -- Corda, M G -- Di Bello, C -- Gessa, G L -- New York, N.Y. -- Science. 1978 May 5;200(4341):552-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/205949" target="_blank"〉PubMed〈/a〉
    Keywords: 3,4-Dihydroxyphenylacetic Acid/metabolism ; Animals ; Caudate Nucleus/*metabolism ; Dopamine/*biosynthesis ; Endorphins/*pharmacology ; Enkephalins/antagonists & inhibitors/*pharmacology ; Homovanillic Acid/metabolism ; Kainic Acid/pharmacology ; Male ; Naloxone/pharmacology ; Rats ; Receptors, Dopamine/drug effects ; Receptors, Opioid/drug effects
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 10
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    Contact-mediated bone resorption by human monocytes in vitro (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-03-03
    Description: Human circulating monocytes in tissue culture are capable of resorbing devitalized adult and fetal bone. An important component of this process is the adhesion of the cells to the mineralized substrate and the localized removal of matrix from beneath the attached cells. The process appears to involve both release of lysosomal enzymes onto the substrate and intracellular accumulation (transport) of resorbed matrix.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kahn, A J -- Stewart, C C -- Teitelbaum, S L -- New York, N.Y. -- Science. 1978 Mar 3;199(4332):988-90.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/622581" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bone Matrix/cytology/metabolism/physiology ; *Bone Resorption ; Bone and Bones/embryology/metabolism ; Calcium Radioisotopes ; Cell Adhesion ; Culture Techniques ; Humans ; Monocytes/cytology/metabolism/*physiology ; Rats
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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