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  • Articles  (7)
  • Cell Differentiation  (7)
  • American Association for the Advancement of Science (AAAS)  (7)
  • Blackwell Publishing Ltd
  • 1975-1979  (7)
  • Physics  (7)
  • 1
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    Bone marrow origin of hepatic macrophages (Kupffer cells) in humans (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-09-08
    Description: Hepatic macrophages (Kupffer cells) from two male recipients of bone marrow transplants from females were studied for fluorescent Y body staining and sex chromatin (Barr body). After the transplant, macrophages had the sex karyotype of the donor, indicating that human hepatic macrophages originate in bone marrow.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gale, R P -- Sparkes, R S -- Golde, D W -- New York, N.Y. -- Science. 1978 Sep 8;201(4359):937-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/356266" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; *Bone Marrow Cells ; Bone Marrow Transplantation ; Cell Differentiation ; Cell Movement ; Female ; Graft vs Host Disease/immunology ; Humans ; Kupffer Cells/*cytology ; Male ; Transplantation, Homologous
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Nature and nurture in development of the autonomic neuron (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-03-31
    Description: Arguments are presented for the hypothesis that during an early stage of development the cells which become principal neurons of the autonomic nervous system possess information regarding the positions they will occupy within the body. A second stage of development, during which a decision is made regarding which neurotransmitter to employ, is delayed until each neuron has assumed its permanent position in the body and has sampled, presumably via its growing axons, the peripheral field which it will innervate. The development of cholinergic mechanisms takes precedence; adrenergic neurons may develop only when cholinergic sites have been occupied. An extended period during which the differentiation of transmitter mechanisms may be modulated permits the neuron to adequately sample the periphery prior to commitment to a specific transmitter economy.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bunge, R -- Johnson, M -- Ross, C D -- New York, N.Y. -- Science. 1978 Mar 31;199(4336):1409-16.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24273" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenergic Fibers/cytology ; Animals ; Autonomic Nervous System/*embryology/growth & development ; Cell Differentiation ; Cells, Cultured ; Chimera ; Cholinergic Fibers/cytology ; Embryonic Induction ; Ganglia, Autonomic/cytology ; Heart/innervation ; Intestines/innervation ; Nerve Endings/ultrastructure ; Neurotransmitter Agents/metabolism ; Phylogeny ; Synaptic Vesicles/ultrastructure
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Timers in developing systems (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-03-02
    Description: Conditional methods are proposed for investigating the number and relationships of processes that are rate-limiting for the genesis of consecutive stages in a developmental sequence. These methods depend on the differential sensitivity of "timer" pathways to small changes in temperature and can be applied to any developmental sequence in which discrete stages can be reproducibly monitored with time. We have applied the methods to multicellular morphogenesis in the slime mold Dictyostelium discoideum and have obtained an unexpected tentative scheme for timer relationships. A minimum of six timers has been delineated, each specific for at least one morphological stage. The majority of these timers appear to be in parallel.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Soll, D R -- New York, N.Y. -- Science. 1979 Mar 2;203(4383):841-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/419408" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biological Clocks ; Cell Adhesion ; Cell Differentiation ; Dictyostelium/*cytology ; Embryo, Nonmammalian/*physiology ; *Models, Biological ; Morphogenesis ; Temperature
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Rod-cone dysplasia in Irish setters: a defect in cyclic GMP metabolism in visual cells (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-09-22
    Description: An abnormality in retinal guanosine 3,5-monophosphate (cyclic GMP) metabolism is demonstrated in the inherited rod-cone dysplasis of Irish Setter dogs. Affected visual cells are deficient in cyclic GMP phosphodiesterase activity and have elevated levels of cyclic GMP. The biochemical abnormalities observed in affected retinas of Irish Setters are similar to those in the retinas of mice with inherited retinal degeneration before visual cell degeneration begins. A defect in cyclic GMP metabolism may be characteristic of early-onset degenerative diseases of the retina, possibly including those that affect humans.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Aquirre, G -- Farber, D -- Lolley, R -- Fletcher, R T -- Chader, G J -- New York, N.Y. -- Science. 1978 Sep 22;201(4361):1133-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/210508" target="_blank"〉PubMed〈/a〉
    Keywords: 3',5'-Cyclic-GMP Phosphodiesterases/*deficiency ; Animals ; Cell Differentiation ; Chromosome Aberrations/genetics/metabolism/pathology/veterinary ; Chromosome Disorders ; Cyclic GMP/*metabolism ; Dog Diseases/genetics/*metabolism/pathology ; Dogs ; Kinetics ; Mice ; Photoreceptor Cells/metabolism/pathology ; Retina/enzymology/*metabolism/pathology ; Retinal Degeneration/genetics/metabolism/pathology/*veterinary
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
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    Genetic basis of XX male syndrome and XX true hermaphroditism: evidence in the dog (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-08-18
    Description: Serological analysis of white blood cells from the members of a family of American cocker spaniels indicates that a form of abnormal sexual development, in which individuals with a female karyotype have testes or ovotestes, is caused by anomalous transmission of male-determining H-Y genes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Selden, J R -- Wachtel, S S -- Koo, G C -- Haskins, M E -- Patterson, D F -- New York, N.Y. -- Science. 1978 Aug 18;201(4356):644-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/675252" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Differentiation ; Disorders of Sex Development/immunology/*veterinary ; Dog Diseases/*genetics ; Dogs ; Female ; Genes ; Genetic Linkage ; Histocompatibility Antigens/*genetics ; Leukocytes/immunology ; Male ; Ovary/growth & development ; Testis/growth & development ; Y Chromosome/immunology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
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    Cell lineage analysis by intracellular injection of a tracer enzyme (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-12-22
    Description: Cell lineages during development of leeches can be ascertained by injection of horseradish peroxidase as a tracer into identified cells at early stages of embryogenesis. The injected embryos continue their normal development, in the course of which horseradish peroxidase is passed on in catalytically active form to the descendants of the injected cell. The distribution of the tracer enzyme and hence of the progeny of the injected cell can then be observed at a later stage of development by staining the preparation for horseradish peroxidase.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Weisblat, D A -- Sawyer, R T -- Stent, G S -- New York, N.Y. -- Science. 1978 Dec 22;202(4374):1295-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/725606" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Differentiation ; Horseradish Peroxidase ; Leeches/cytology/*embryology ; Methods
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 7
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    Common origin of pigment cells (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-02-02
    Description: The fundamentally diverse vertebrate pigment cells, melanophores, xanthophores, and iridophores, contain pigmentary organelles known, respectively, as melanosomes, pterinosomes, and reflecting platelets. Their pigments are mealanins pteridines, and purines. Mosaic pigment cells containing more than one type of organelle have been observed and mosaic organelles containing more than one type of pigment have been discovered. It is proposed that the various pigment cells are derived from a stem cell that contains a primordial organelle of endoplasmic reticular origin. This primordial organelle can differentiate into any of the known pigmentary organelles.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bagnara, J T -- Matsumoto, J -- Ferris, W -- Frost, S K -- Turner, W A Jr -- Tchen, T T -- Taylor, J D -- New York, N.Y. -- Science. 1979 Feb 2;203(4379):410-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/760198" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Differentiation ; Chromatophores/metabolism/*ultrastructure ; Endoplasmic Reticulum/metabolism ; Models, Biological ; Neural Crest/*cytology ; Organoids/ultrastructure ; *Pigmentation ; Pigments, Biological/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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