Publication Date:
1979-04-20
Description:
Norepinephrine increases the concentration of adenosine 3',5'-monophosphate (cyclic AMP) in an incubated suspension of brain microvessels. This response can be matched by other drugs that stimulate the beta receptors, but the alpha-adrenergic agonist phenylephrine is without effect; beta-adrenergic blockade abolishes the response while alpha-adrenergic blockade produces no change. The data support the contention that cerebral capillary function is subject to adrenergic neural control.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Herbst, T J -- Raichle, M E -- Ferrendelli, J A -- New York, N.Y. -- Science. 1979 Apr 20;204(4390):330-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/34879" target="_blank"〉PubMed〈/a〉
Keywords:
Adrenergic beta-Agonists/*pharmacology
;
Animals
;
Capillaries/innervation/*metabolism
;
*Cerebrovascular Circulation
;
Cyclic AMP/*metabolism
;
Dose-Response Relationship, Drug
;
Male
;
Norepinephrine/pharmacology
;
Rats
;
Sympatholytics/pharmacology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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