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  • 1
    ISSN: 1432-2048
    Keywords: Bryophyllum ; Crown-gall ; 3′:5′-cyclic-AMP phosphodiesterase ; Theophylline
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract In crown-gall tumor tissue obtained from leaves of Bryophyllum daigremontianum an adenosine 3′:5′-cyclic phosphate (3′:5′-cyclic-AMP) degrading activity increases up to 2.5 fold until the fifth day after inoculation with Agrobacterium tumefaciens, declining to the value of the control in the solid tumor. Theophylline up to 1 mmol l−1 given to wounded leaves of Bryophyllum daigremontianum has no effect on the number of tumors. The effect of higher concentrations given over extended periods can be explained otherwise. Therefore it seems likely that the 3′:5′-cyclic-AMP phosphodiesterase (EC 3.1.4.17) has no effect on transformation and growth of crown-gall tumors in Bryophyllum daigremontianum.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 16 (1979), S. 345-349 
    ISSN: 1432-1041
    Keywords: testosterone ; testosterone undecanoate ; arachis oil ; serum level ; oral administration
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Twenty-six male volunteers received a single oral dose of testosterone as free crystals or as the undecanoate ester. The latter was given either in crystalline form or in arachis oil. All preparations were tested three times in the same individual, whilst fasting on 2 days and on one day together with a breakfast rich in fat. Serum testosterone concentration was measured at intervals for up to 6–24h after the dose. A significant and reproducible rise in serum testosterone level was found after ingestion of free testosterone. Testosterone esterified with undecylenic acid was only effective when administered in arachis oil. The meal increased the bioavailability of the ester, but had hardly any effect on that of the free hormone. It is concluded that bioavailability of oral testosterone can be improved by pharmaceutical means to an extent sufficient to produce adequate blood levels in substitution therapy.
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 11 (1977), S. 129-133 
    ISSN: 1432-1041
    Keywords: carbamazepine ; carbamazepine-10,11-epoxide ; plasma concentration ; CSF concentration ; children ; adult
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The plasma concentrations of carbamazepine and its 10,11-epoxide were measured in 37 children and 13 adults with epilepsy during maintenance therapy. The children formed relatively more of the epoxy metabolite than adults. The daily dose, expressed as mg/kg or mg/m2, showed a statistically significant correlation with blood level in children, but not in adults. The cerebrospinal fluid concentrations of carbamazepine and carbamazepine-10,11-epoxide in nine children were 33 and 41 per cent, respectively, of the concomitant plasma level.
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Fresenius' Zeitschrift für analytische Chemie 139 (1953), S. 58-62 
    ISSN: 1618-2650
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Fresenius' Zeitschrift für analytische Chemie 139 (1953), S. 53-53 
    ISSN: 1618-2650
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Fresenius' Zeitschrift für analytische Chemie 138 (1953), S. 131-133 
    ISSN: 1618-2650
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Fresenius' Zeitschrift für analytische Chemie 139 (1953), S. 58-58 
    ISSN: 1618-2650
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Fresenius' Zeitschrift für analytische Chemie 139 (1953), S. 378-378 
    ISSN: 1618-2650
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    European journal of wildlife research 22 (1976), S. 50-61 
    ISSN: 1439-0574
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Description / Table of Contents: Summary From October 1972 through October 1973, about three seemingly healthy hare were shot in each of three hunting districts of Lower Austria. They were examined pathologically for parasites and bacteria, and biological data were collected. The number of young per female hare was 3 to 4, with an average litter size of 3.3. A third of the adult females did not participate in mating activity during the main mating period. The earliest discernible pregnancy (foetus) was found in mid January the latest at the end of August. This means that the hare hunting season must be limited to December 15 at the latest. A longer season should be firmly rejected for biological reasons and not allowed even in wine growing regions. Twelve endoparasites (Eimeria europaea, E. hungarica, E. leporis, E. robertsoni, E. semisculpta, E. spec., E. stefanskii, E. townsendi, Trichostrongylus retortaeformis, Trichuris leporis, Protostrongylus commutatus, Cysticercus pisiformis) and two ectoparasites (Ixodes ricinus, Silopsyllus cuniculi) were found altogether. The examination of serum for tularamia, brucellosis and toxoplasmosis was negative. The bacteriological examination revealed, in addition to the known pathological agents such asPasteurella pseudotuberculosis, Salmonella typhimurium andClostridium perfringens also the contaminatorsKlebsiella, Pseudomonas, which could be responsible for losses under certain conditions. The examinations show that hare live under constant exposure to parasites. In the case of coccidia, the hares are regularly infested to a low degree the whole year through, as is true forTrichostrongylus retortaeformis. Trichuris leporis however, show three maxima, in January–February, in May, and again in October.
    Abstract: Résumé Dans trois territoires de chasse de Basse-Autriche, une moyenne par territoire de trois lièvres, apparemment sains, ont été tirés d'octobre 1972 à octobre 1973 et soumis à un examen anatomique, pathologique, parasitologique et bactériologique; en outre, des données biologiques ont été recueillies. La portée des hases était de 3 à 4, soit de 3,3 en moyenne. Au cours de la phase maximale de reproduction, un tiers des hases adultes ne participait pas au cycle de reproduction. La gravidité la plus précoce (stade foetal) fut constatée à la mi-janvier, la plus tardive à la fin août. Cette constatation signifie qu'il n'est pas biologiquement recommandable d'étendre la période de chasse au-delà du 15 décembre même en ce qui concerne les régions viticoles. Au total, on put mettre en évidence 12 endoparasites (Eimeria europaea, F. hungarica, E. leporis, E. robertsoni, E. semisculpta, E. spec., E. stefanskii, E. townsendi, Trichostrongylus retortaeformis, Trichuris leporis, Protostrongylus commutatus, Cysticercus pisiformis) et 2 espèces d'ectoparasites (Ixodes ricinus, Silopsyllus cuniculi). L'analyse sérologique en vue de déceler la Tularémie, la Brucellose et la Toxoplasmose fut négative. Les examens bactériologiques révélèrent en dehors de germes pathogènes connus tels quePasteurella pseudotuberculosis, Salmonella typhimurium etClostridium perfringens, des Klebsiella et des Pseudomonas qui, dans certaines conditions, peuvent être rendus responsables de mortalités. Les examens montrent que le Lièvre est exposé à une agression parasitaire permanente. Les coccidies de même queTrichostrongylus retortaeformis révèlent une activité uniforme tout au long de l'année tandis queTrichuris leporis montre trois maxima à savoir en janvier-février, en mai et en octobre.
    Notes: Zusammenfassung In drei niederösterreichischen Niederwildgebieten wurden von Oktober 1972 bis Oktober 1973 monatlich durchschnittlich je 3 gesund erscheinende Feldhasen erlegt und pathologisch-anatomisch, parasitologisch und bakteriologisch untersucht sowie biologische Daten gesammelt. Die Satzzahl der Häsinnen beträgt 3 bis 4 mit einer durchschnittlichen Satzgröße von 3,3. Ein Drittel der adulten Häsinnen war während der Hauptreproduktionsphase nicht am Vermehrungszyklus beteiligt. Die früheste Trächtigkeit (bereits Feten) wurde Mitte Januar, die späteste Ende August festgestellt. Für die Praxis bedeutet dies, daß die Hasenschußzeit mit spätestens 15. Dezember limitiert werden muß. Eine längere Abschußzeit ist vom biologischen Standpunkt strikt abzulehnen und auch für Weinbaugebiete nicht gerechtfertigt. Ingesamt konnten 12 Endoparasitenarten (Eimeria europaea, E. hungarica, E. leporis, E. robertsoni, E. semisculpta, E. spec., E. stefanskii, E. townsendi, Trichostrongylus retortaeformis, Trichuris leporis, Protostrongylus commutatus, Cysticercus pisiformis) und 2 Ektoparasitenarten (Ixodes ricinus, Silopsyllus cuniculi) nachgewiesen werden. Die serologische Untersuchung auf Tularämie, Brucellose und Toxoplasmose ergab ein negatives Ergebnis. Bei den bakteriologischen Untersuchungen konnten neben den bekannt pathogenen Erregern wiePasteurella pseudotuberculosis, Salmonella typhinmurium undClostridium perfringens auch Kontaminanten (Klebsiella, Pseudomonas) nachgewiesen werden, die unter bestimmten Voraussetzungen für Ausfälle verantwortlich zeichnen können. Die Untersuchungen zeigen, daß die Feldhasen einer ständigen parasitären Belastung ausgesetzt sind. Bei den Kokzidien liegt ein gleichmäßiger mittelgradiger Befall über das gesamte Jahr hin vor, ebenfalls beiTrichostrongylus, retortaeformis. BeiTrichuris leporis zeichnen sich dagegen drei Maxima ab, und zwar im Januar/Februar, Mai und Oktober.
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Fresenius' Zeitschrift für analytische Chemie 134 (1951), S. 273-275 
    ISSN: 1618-2650
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Zusammenfassung Ein neuer empfindlicher, leicht auszuführender Nachweis von Tetramethylthiuramdisulfid in vulkanisierten und unvulkanisierten Gummimischungen, der in Umkehrung auch zum Nachweis von „Alterungsschutzmittel 4010“ benutzt werden kann, wurde beschrieben. Thiuram gibt in Gegenwart von 4010 in Acetonlösung bei Zugabe von wäßriger Kupfersulfatlösung eine tiefschwarze, beim Verdünnen rot erscheinende Färbung.
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