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  • Analytical Chemistry and Spectroscopy  (347)
  • Life and Medical Sciences  (171)
  • Wiley-Blackwell  (518)
  • Annual Reviews
  • Oxford University Press
  • Springer
  • 1975-1979  (480)
  • 1950-1954  (38)
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  • Wiley-Blackwell  (518)
  • Annual Reviews
  • Oxford University Press
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  • 11
    Electronic Resource
    Electronic Resource
    The characterization of SV40-transformed cell lines derived from mouse teratocarcinoma: Growth properties and differentiated characteristicsA portion of this work was presented at the Conference on “Regulation of Gene Expression in Development and Neoplasia” which was published in Cancer Research, 36, 4217-4223, 1976. (1977)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 93 (1977), S. 269-276 
    Details
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: Mouse teratocarcinoma cells derived from embryoid bodies of 129SVsl mice were cultured in vitro to permit their differentiation. These cells were then infected with simiam virus 40 (SV40) and 31 cloned cell lines (SVTER) were derived from these cultures. All 31 SVTER cell lines contained the SV40 tumor (T) antigen and grew as permanent lines in culture. Mock-infected embryoid body cultures did not give rise to permanent cell lines. The morphology of each SVTER cell line was distinct and did not change during successive subclonings.The growth properties and tumorigenic potential of all 31 SVTER cell lines were investigated. None of these lines produced tumors in 129SVsl mice. Each cell line was tested for its ability to (1) grow in medium containing 1% serum, (2) plate on a cell monolayer, and (3) form clones in methocel suspension. Only three of the SVTER cell lines were transformed with respect to all three of these criteria. Most of these cell lines were minimal transformation.The SVTER cell lines were tested for creatine phosphokinase (CPK), an enzyme activity characteristic of mouse brain and muscle tissue, and the protease, plasminogen activator (PA) which is found in embryoid bodies and several differentiated cell types. Some of the SVTER cell lines contained high levels of CPK, while others had high levels of PA and a third group of cells contained neither enzyme activity. No SVTER cell line was found with high levels of both these enzyme activities. This result suggests that mutually exclusive sets of genes are expressed in these cells as might be expected from the distinct tissue distribution of the two enzyme activities studied. These SVTER cell lines may be useful in reconstructing developmental pathways of differentiating teratomas in vitro.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcp.1040930212
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  • 12
    Electronic Resource
    Electronic Resource
    A selected ion monitoring assay for primaquine in plasma and urine (1979)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 6 (1979), S. 109-112 
    Details
    ISSN: 0306-042X
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The antimalarial drug primaquine was analysed in plasma and urine by gas chromatography mass spectrometry, using a deuterated internal standard. After freeze-drying and extraction with trichloroethylene the sample plus internal standard was reacted with Tri Sil TBT (a) 3:3:2 by volume mixture of trimethylsilylimidazole, N,O,-bis-(trimethylsilylacetamide and trimethylchlorosilane) and an aliquot injected into the gas chromatograph mass spectrometer. The gas chromatographic effluent was monitored at m/z 403 and m/z 406, the molecular ions of the bis-TMS ethers of primaquine and 6-trideuteromethoxy primaquine. Calibration curves were prepared from standards made up in plasma and urine. Data from the analysis of plasma and urine samples from a volunteer who ingested the equivalent of 45 mg primaquine are presented.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200060306
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  • 13
    Electronic Resource
    Electronic Resource
    Quantitation of plasma warfarin levels by gas chromatography chemical ionization mass spectrometry (1979)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 6 (1979), S. 101-104 
    Details
    ISSN: 0306-042X
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A quantitative assay for plasma concentrations of warfarin has been developed using a deuterated warfarin analogue as internal standard. The method employs methylation (diazomethane) of warfarin to its 4′-methoxy derivative and gas chromatography chemical ionization mass spectrometry. Selected ion monitoring was used to relate the response of warfarin methyl ether and the internal standard. This technique can measure warfarin plasma concentrations five days after a single oral (25 mg) dose. Warfarin half-lives were determined in 12 healthy male volunteers. Each plasma analysis required six minutes of instrument time.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200060304
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  • 14
    Electronic Resource
    Electronic Resource
    Plasma quantitation of warfarin and warfarin alcohol by gas chromatography chemical ionization mass spectrometry in patients on warfarin maintenance therapy (1979)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 6 (1979), S. 208-211 
    Details
    ISSN: 0306-042X
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A quantitative method has been developed to measure plasma concentrations of warfarin and warfarin alcohol. The analytical procedure uses deuterated analogues as internal standards, and the technique of selected ion monitoring following gas chromatography methane chemical ionization mass spectrometry of the 4′-methyl ethers of warfarin and warfarin alcohol. Concentrations of warfarin and warfarin alcohol have been measured in plasma samples from 43 patients maintained on chronic warfarin therapy and compared with the ‘apparent warfarin’ concentration as measured by a fluorometric procedure. The study demonstrated a high degree of correlation between the gas chromatographic mass spectrometric derived sum of the individual concentrations of warfarin and warfarin alcohol, and the ‘apparent warfarin’ concentration determined from a spectrofluorometric assay.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200060508
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  • 15
    Electronic Resource
    Electronic Resource
    A microprocessor controlled mass spectrometer for the fully automated purification and isotopic analysis of breath carbon dioxideThis work was supported by the National Institutes of Health through grant AM 18741 and the US Department of Energy. The work was performed at both the University of Chicago and Argonne National Laboratory. This paper was presented in part at the Third International Conference on Stable Isotopes, Oak Brook, Illinois, USA (1978) and has appeared in abstract form in the conference proceedings. (1979)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 6 (1979), S. 350-355 
    Details
    ISSN: 0306-042X
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Breath tests that measure the oxidative utilization of 13C labeled substrates have been shown to be clinically useful, but have failed to gain wide acceptance because of the slow and costly isotopic analysis of the breath samples. Therefore we have developed a fully automated, microprocessor controlled CO2 purification and isotopic analysis system. The breath CO2 is cryogenically purified by passage through cold traps of -94°C and -196°C to condense water and CO2, respectively. The CO2 is introduced into a dual inlet, peak-stepping mass spectrometer and analyzed for isotopic content by comparison with a known standard. Thirty samples can be analyzed without operator intervention. Analysis time averages 14 minutes per sample, and the analysis has a precision of 0.3‰ which corresponds to 3 parts excess 13C per 106 parts CO2. The speed of analysis is comparable with scintillation counting and permits next day reporting of clinical breath test results. The precision is sufficient for clinical applications as it is less than the 0.7‰ isotopic variation in basal breath CO2.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200060809
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  • 16
    Electronic Resource
    Electronic Resource
    Analysis of carotenoids by field desorption mass spectrometry (1975)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 10 (1975), S. 1102-1110 
    Details
    ISSN: 0030-493X
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The mass spectra of a variety of authentic carotenoids covering a range of structural types have been studied using the field desorption technique. All the compounds examined show the molecular ion as the base peak, even where this ion is of very low intensity in the electron-impact spectra. Little fragmentation is observed, but thermal decomposition can be induced in certain cases by using higher emitter currents. Application to a simple mixture of authentic compounds and a more complex mixture of sedimentary origin shows the potential of the method in the rapid qualitative screening of carotenoids in crude extracts.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/oms.1210101207
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  • 17
    Electronic Resource
    Electronic Resource
    Laser assisted field desorption mass spectrometry (1978)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 13 (1978), S. 361-365 
    Details
    ISSN: 0030-493X
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The method of indirectly heating the emitter wire with a laser is introduced into field desorption mass spectrometry. Use of this method results in improved sensitivity, more reliable high resolution performance, and extension of field desorption mass spectrometry to the area of high temperature chemistry.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/oms.1210130612
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  • 18
    Electronic Resource
    Electronic Resource
    Nuclear magnetic resonance and the conformation of some derivatives of Michler's ketone (1975)
    Chichester : Wiley-Blackwell
    Organic Magnetic Resonance 7 (1975), S. 154-159 
    Details
    ISSN: 0030-4921
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: 1H NMR spectra are reported for Michler's ketone and twenty of its derivatives, along with 13C chemical shifts for five of the compounds. 1H chemical shifts show only small changes with increasing substitution at the sterically hindered 2-position. Estimates of the dihedral angle between the benzene ring and C—CO—C planes have been obtained from the chemical shifts of C=O and 4-C for ketones 1, 3, 5, 15 and 16. These angles are both internally consistent and very similar to dihedral angles determined by other methods for corresponding compounds in the benzophenone series.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mrc.1270070403
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  • 19
    Electronic Resource
    Electronic Resource
    Spectres RMN des Polysaccharides et de leurs Dérivés: Influence des Substituants sur le Déplacement Chimique 13C (1978)
    Chichester : Wiley-Blackwell
    Organic Magnetic Resonance 11 (1978), S. 344-349 
    Details
    ISSN: 0030-4921
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Methyl and acetyl substituent effects on 13C chemical shift have been determined on (α 1→3), (α 1→4), (β 1→3) and (β 1→4) linked polysaccharides such as pseudo-nigerane, β-cyclodextrine, amylose, laminarane and cellulose. Methyl α- and β-D-glucopyranoside have been used as monomer model compounds. Shift determination of hydroxylated and substituted polysaccharides requires unambiguous assignment of their 13C spectra. Selective heteronuclear spin decoupling and the isotope effect of deuterated hydroxyl have been used as assignment techniques.
    Notes: L'influence des substituants méthyle et acétate sur le déplacement chimique 13C a été déterminée sur les polysaccharides liés par liaison glycosidique (α1→3), (α1→4), (β1→3) et (β1→4) suivants: pseudonigérane, β-cyclodextrine, amylose, laminarane et cellulose. Nous avons utilisé les méthyl α et β glucopyranosides comme composés modès. La détermination de l'effet des substituants sur le déplacement chimique 13C nécessite l'attribution non ambiguë des spectres 13C des polysaccharides hydroxylés et substitués. On a utilisé pour cela la technique d'irradiation sélective hétéronucléaire et l'effet isotopique d'hydroxyle deutérié.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mrc.1270110706
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  • 20
    Electronic Resource
    Electronic Resource
    Substituent group effects on the NQR frequency of Cl in certain chloromethane derivatives (1979)
    Chichester : Wiley-Blackwell
    Organic Magnetic Resonance 12 (1979), S. 655-658 
    Details
    ISSN: 0030-4921
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: An empirical method is suggested for estimating the NQR frequencies of substituted chloromethanes. The frequencies are given by the equation νCl = νo + ∑imi, where the parameters mi are characteristic of the substituent groups, with additive properties in the case of multiple substitution for substituted chloromethanes. The calculations reveal that (i) as in chlorobenzenes, the effect of substituent groups on the NQR frequencies is additive to a first order of approximation, (ii)the effect is much larger in chloromethanes than in chlorobenzenes, (iii) the relative effects of different substituent groups are similar in the two sets, (iv) where there is more than one substituent group their mutual interaction is of the same order of magnitude as the crystal field effects.
    Additional Material: 4 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mrc.1270121112
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